Protective effect of atorvastatin on bone tissue in orchidectomised male albino Wistar rats

Gradosova, Iveta; Zivna, Helena; Palička, Vladimír; Hubena, Sona; Svejkovska, Klara; Živný, Pavel

doi:10.1016/j.ejphar.2012.01.014

Cited by 13 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Preceding studies using male osteoporosis experimental models targeted aged orchiectomized male white rats23 and sought to analyze the antiresorptive and protective effects of medications such as atorvastatin, amlodipine, calcitonin, raloxifene, risedronate, green tea polyphenols, and soy protein with isoflavones on bones 1011262728. However, BMD loss after orchiectomy occurs only under exceptional circumstances of sex gland removal.…”

Section: Discussionmentioning

confidence: 99%

“…There are clinical reports of an increased incidence of osteoporosis in elderly men8 and prostate cancer patients following orchiectomy,9 suggesting that androgen deprivation leads to osteoporosis 1011. An osteoporotic male animal model can be generated effectively in young rats,12 and although there are many reports comparing and analyzing the serum bone formation and resorption markers in aged male orchiectomized rats, there have been no published studies on young castrated male rats.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Bone Metabolism in Young Castrated Male Rats

Ryu

Kim

et al. 2016

Yonsei Med J

View full text Add to dashboard Cite

PurposeTo determine the window of time during which osteoporosis affects the management of spinal surgery and the mechanism of bone metabolism changes in males with osteoporosis by examining changes in bone metabolism in young castrated male rats.Materials and MethodsA total of 30 Sprague-Dawley rats were randomly allocated into two study groups. Group 1 (control) received a sham surgery and Group 2 received bilateral orchiectomy to change bone mineral density (BMD). Serum osteocalcin, alkaline phosphatase (ALP), and collagen type 1 cross-linked C-telopeptide (CTX) were analyzed at postoperative date (POD) 8, 10, and 12 weeks. BMDs were measured using micro computed tomography scans.ResultsFemoral and lumbar BMDs were decreased in the orchiectomy groups. BMDs in the sham and orchiectomy groups showed statistically differences at POD 8, 10, and 12 weeks for the femur (p=0.032, 0.008, 0.008) and lumbar spine (p=0.151, 0.008, 0.008, respectively). Serum osteocalcin, ALP, and CTX decreased gradually; however, N-terminal type 1 procollagen (P1NP) showed a slight increase yet no significant change.ConclusionIn young castrated male rats, a significant decrease in BMD was observed after orchiectomy due to the mixture of two detrimental factors. Young castrated male rats did not reach peak BMD. Increased bone turnover causes bone resorption to exceed bone formation. This study may contribute to the creation of a valuable model for studies of male osteoporosis and the spinal surgery field.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in Bone Metabolism in Young Castrated Male Rats

Ryu

Kim

et al. 2016

Yonsei Med J

View full text Add to dashboard Cite

show abstract

“…Mechanical testing of the rat femoral shaft and femoral neck was done with a special electromechanical custom-made testing machine (Martin Kosek and Pavel Trnecka, Hradec Kralove, Czech Republic) according to our methods described in a previous report [16]. For the three-point bending test, the femur or tibia was placed on a holding device with the two support points 18 mm apart.…”

Section: Methods and Evaluation Of Bone Qualitymentioning

confidence: 99%

The Effect of Zonisamide on Rat Bone Mass, Structure, and Metabolism

Karesova¹,

Simko²,

Fekete³

et al. 2023

Pharmacology

View full text Add to dashboard Cite

Introduction: Our study aimed to investigate the effect of zonisamide (ZNS) on bone metabolism in the rat model. Methods: Eight-week-old rats were divided into four groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group after orchidectomy (ORX+ZNS) and the sham-operated control group (SHAM+ZNS) received SLD enriched with ZNS for 12 weeks. Bone marker concentrations in serum of receptor activator of nuclear factor kappa B ligand, PINP, and osteoprotegerin, and the levels of sclerostin and bone alkaline phosphatase in bone homogenate, were measured using an enzyme-linked immunosorbent assay. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. The femurs were used for biomechanical testing. Results: We found a statistically significant reduction in BMD and biomechanical strength 12 weeks after orchidectomy of the rats (ORX). After ZNS administration to orchidectomized rats (ORX+ZNS) and the sham-operated control rats (SHAM+ZNS), there were no statistically significant changes in BMD, bone turnover markers, or biomechanical properties as compared with the ORX group and SHAM group. Conclusions: The results suggest that administration of ZNS to rats exerts no negative effect on BMD, bone metabolism markers, or biomechanical properties.

show abstract

“…Consequently, it is very important to understand their effect. Many articles have been published regarding the effects of anti-resorptive drugs in orchiectomized animal models of male osteoporosis 1 6 11) . However, before the effects of these drugs are evaluated in animal models, it is also important to validate whether the animal model is already compromised by osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats

Ryu

Kim

et al. 2015

Korean J Spine

View full text Add to dashboard Cite

ObjectiveTo investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking.MethodsTwenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery.ResultsFemoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery.Conclusion8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.

show abstract

Protective effect of atorvastatin on bone tissue in orchidectomised male albino Wistar rats

Cited by 13 publications

References 24 publications

Changes in Bone Metabolism in Young Castrated Male Rats

Changes in Bone Metabolism in Young Castrated Male Rats

The Effect of Zonisamide on Rat Bone Mass, Structure, and Metabolism

Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats

Contact Info

Product

Resources

About