Protective effect of berberine, an isoquinoline alkaloid ameliorates ethanol-induced oxidative stress and memory dysfunction in rats

Patil, Shaktipal; Tawari, Santosh; Mundhada, Dharmendra; Sayyed, Nadeem

doi:10.1016/j.pbb.2015.07.001

Cited by 71 publications

(35 citation statements)

References 42 publications

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“…(37) Several studies have revealed that constituents in JXR including Fructus Ligustri Lucidi, Radix Astragali, Rhizoma Coptidis, can ameliorate oxidative stress and exhibit antioxidant activity. (38)(39)(40) In the present study, JXR showed antioxidant defense with increased SOD activity and decreased MDA contents in diabetic rats. Therefore, the protection of diabetic retina may be through enforcing antioxidant defense.…”

Section: Discussionsupporting

confidence: 60%

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Zhou

et al. 2016

Chin. J. Integr. Med.

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Section: Discussionsupporting

confidence: 60%

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Zhou

et al. 2016

Chin. J. Integr. Med.

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“…Psychostimulants/psycholeptics have been shown to induce the stimulation/inhibition of the central nervous system (CNS), causing enhancement/weakness to motor function and affecting behavioral performance (Singh et al, 2011). To investigate whether efficacy of 1-MT on emotional deficits was related to CNS stimulation/inhibition, each mouse received a locomotor activity test, an index of wakefulness or alertness of mental activity (Patil et al, 2015). No difference of locomotor activity was observed among groups, indicating that neither 1-MT nor drinking interfered with the accuracy of the results obtained from behavioral tests.…”

Section: Discussionmentioning

confidence: 99%

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

Jiang¹,

Lin²,

Li³

et al. 2020

Front. Cell. Neurosci.

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Objective: Our study was designed to investigate whether the indoleamine-2,3dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits from ethanol addiction/withdrawal mice. Methods:The expression of proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), was tested by enzyme-linked immunosorbent assay (ELISA). The IDO levels in the hippocampus, cerebral cortex, and amygdala were measured by polymerase chain reaction (PCR) and western blot, and the neurotransmitters were tested by high performance liquid chromatography (HPLC). Emotional deficits of mice were evaluated by behavioral tests.Results: Expression levels of inflammatory factors (TNF-α, IL-1β, and IL-6) were increased in mice after 4 weeks of alcohol exposure. As for indoleamine 2,3dioxygenase (IDO) expression, only the subtype IDO1 was found to increase at both mRNA level and protein level in all the tested brain regions of ethanol addiction/withdrawal mice. In behavioral tests, mice exposed to alcohol showed gradually declined memory function accompanied by anxiety-like and depressive-like behaviors. Meanwhile, increased expression of KYN, decreased expression of 5-HT, and abnormal expression of 3-HK and KA were found in the hippocampus, cerebral cortex, and amygdala of ethanol addiction/withdrawal mice. Interestingly, the IDO1 inhibitor, 1-methyl-L-tryptophan (1-MT), reversed all above alterations induced by ethanol in mice. Conclusion:Our results suggested that the TRP/KYN pathway, medicated by IDO1, in the hippocampus, cerebral cortex, and amygdala, plays an important role in the development of emotional deficits caused by ethanol addiction and withdrawal.

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“…Two independent recent studies showed BBR protects the liver from ethanol-induced oxidative stress both in mice (Zhang et al, 2014) and rats (Patil et al, 2015). The neuroprotective effect of BBR against LD may result from diminished oxidative stress and inhibition of microglial activation.…”

Section: Discussionmentioning

confidence: 99%

Berberine protects against light-induced photoreceptor degeneration in the mouse retina

Song

Wang

et al. 2016

Experimental Eye Research

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Oxidative stress and inflammation play key roles in the light damage (LD) model of photoreceptor degeneration, as well as in age-related macular degeneration (AMD). We sought to investigate whether Berberine (BBR), an antioxidant herb extract, would protect the retina against light-induced degeneration. To accomplish this, Balb/c mice were treated with BBR or PBS via gavage for 7 days, and then were placed in constant cool white light-emitting diode (LED) light (10,000 lux) for 4 hours. Retinal function and degeneration were evaluated by histology, electroretinography (ERG) and optical coherence tomography (OCT) at 7d after LD. Additionally, mRNA levels of cell-type specific, antioxidant, and inflammatory genes were compared 7d after LD. Photoreceptor DNA fragmentation was assessed via the terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) assay. LD resulted in substantial photoreceptor-specific cell death. Histological analysis using plastic sections showed dosing with BBR preserved photoreceptors. The ERG analysis demonstrated functional protection by BBR in rod-b, -a, and cone-b waves. In OCT images, mice receiving PBS showed severe thinning and disorganization of the photoreceptor layer 7 days after LD, whereas mice treated with BBR had significantly less thinning and disorganization. Consistent with OCT results, the mRNA levels of Rho in the NSR, and Rpe65 and Mct3 in the RPE, were significantly higher in mice treated with BBR. The numbers of TUNEL-positive photoreceptors were significantly decreased in BBR-treated mice. The retinal mRNA levels of oxidative stress genes, the number of microglia/macrophages, and the malondialdehyde (MDA) immunolabeling were significantly lower in BBR-treated mice compared to controls 48h after LD, which indicates oxidative stress was reduced by BBR in light-damaged eyes. In conclusion, systemic BBR is protective against light-induced retinal degeneration associated with diminished oxidative stress in the retina. These results suggest that BBR may be protective against retinal diseases involving oxidative stress.

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Protective effect of berberine, an isoquinoline alkaloid ameliorates ethanol-induced oxidative stress and memory dysfunction in rats

Cited by 71 publications

References 42 publications

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

Berberine protects against light-induced photoreceptor degeneration in the mouse retina

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