Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection

Salem, Mohamed L.; Hossain, M. Shahadat

doi:10.1016/s0192-0561(00)00036-9

Cited by 246 publications

(195 citation statements)

References 29 publications

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“…30,31 It is also used in the treatment of bronchial asthma and eczema. 32 Besides, the essential oil of black cumin was shown to have antihelminthic, 33 antinematodal, 34 antischistosomal, 35 antimicrobial [36][37][38] and antiviral 39 and also headache, flatulence, blood homeostasis abnormalities, rheumatism and related inflammatory diseases effects. 32 Anise Anise (Pimpinella anisum) Figure 4 is a dainty, white flowered herbaceous annual plant growing to 1.6 ft -3 ft or more tall.…”

Section: Treatment and Uses Of Black Cuminmentioning

confidence: 99%

Cuminum cyminum – A Popular Spice: An Updated Review

Singh¹,

Gangadharappa²,

Mruthunjaya³

2017

100

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Section: Treatment and Uses Of Black Cuminmentioning

confidence: 99%

Cuminum cyminum – A Popular Spice: An Updated Review

Singh¹,

Gangadharappa²,

Mruthunjaya³

2017

100

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“…The extracts of N. sativa seeds have been used by patients to suppress coughs disintegrate renal calculi, retard the carcinogenic process (Worthen et al, 1998;Hosseinzadeh et al, 2007) treat abdominal pain, diarrhea, flatulence and polio (Enomoto et al, 2001), exert choleretic and uricosuric activities, antiinflammatory (Chakravarty, 1993;Houghton et al, 1995) and antioxidant effects (Mansour et al, 2002;Mansour, 2000). Besides, the essential oil was shown to have antihelminthic (Agarwal et al, 1979), antinematodal (Akhtar and Riffat, 1991), antischistosomal (Mahmoud et al, 2002), antimicrobial (Aboul-Ela et al, 1996;Hanafy and Hatem, 1991;Aboul-Ela, 2002) and antiviral (Salem and Hossain, 2000) effects. The pharmacological properties appear to be involved in the beneficial effects of N. sativa oil on headache, flatulence, blood homeostasis abnormalities, rheumatism and related inflammatory diseases (Boulos, 1983).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Al-Haj¹,

Shamsudin²,

Alipiah³

et al. 2010

American Journal of Pharmacology and Toxicology

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Problem statement: Seeds of Nigella sativa L., commonly known as black seed, have been used in traditional medicine by many Asian, Middle Eastern and Far Eastern Countries to treat headache, coughs, abdominal pain, diarrhea, asthma, rheumatism and other diseases. The seeds of this plant are the most extensively studied, both phytochemically and pharmacologically. The aqueous and oil extracts of the seeds have been shown to possess especially nowadays in pharmaceutical antioxidant, anti-inflammatory, anticancer, analgesic, antimicrobial activities and medicinal and cosmetic applications, sanitary, cosmetic, agricultural and food industries. Approach: The aim of this study was to formulate a new delivery system for dermal and cosmetic application by the incorporation of Nigella sativa essential oil into solid lipid nanoparticles SLN. SLN formulations were prepared following the high-pressure homogenization after starring and ultra-trax homognization techniques using hydrogenated palm oil Softisan 154 and N. sativa essential oil as lipid matrix, sorbitol and water as surfactants. The SLN formulation particle size was determined using Photon Correlation System (PCS). Results: The change of particle charge was studied by Zeta Potential (ZP) measurements, while the melting and re-crystallization behavior was studied using Differential Scanning Calorimetry (DSC). Data showed a high physical stability for both formulations at various storage temperatures during 3 months of storage. In particular, average diameter of N. sativa essential oilloaded SLN did not vary during storage and increased slightly after freeze-drying the SLN dispersions. Conclusion: Therefore, obtained results showed that the studied SLN formulations are suitable carriers in pharmaceutical and cosmetic fields.

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“…N. sativa extract has shown antimicrobial properties against Escherichia coli, Bacillus subtilis, and other bacteria [35]. Studies of murine cytomegalovirus infection and hepatitis C infection lend support to the plant's antiviral potential in vivo, as well [36,37]. Additionally, N. sativa compound extracts, especially its saponins, alkaloids, and flavonols, show similarities with known antiviral chemicals [38][39][40].…”

Section: Introductionmentioning

confidence: 98%

Sambucus nigra Extracts Inhibit Infectious Bronchitis Virus at an Early Point during Replication

Chen¹,

Zuckerman²,

Brantley³

et al. 2013

Planta Med

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Background: Infectious bronchitis virus (IBV) is a pathogenic chicken coronavirus. Currently, vaccination against IBV is only partially protective; therefore, better preventions and treatments are needed. Plants produce antimicrobial secondary compounds, which may be a source for novel anti-viral drugs. Non-cytotoxic, crude ethanol extracts of Rhodiola rosea roots, Nigella sativa seeds, and Sambucus nigra fruit were tested for anti-IBV activity, since these safe, widely used plant tissues contain polyphenol derivatives that inhibit other viruses.

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Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection

Cited by 246 publications

References 29 publications

Cuminum cyminum – A Popular Spice: An Updated Review

Cuminum cyminum – A Popular Spice: An Updated Review

Characterization of Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles

Sambucus nigra Extracts Inhibit Infectious Bronchitis Virus at an Early Point during Replication

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