Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress

“…Functional foods contain one or more nutraceuticals, and these are defined as ''compounds or products that have been isolated or purified from food sources that are health-promoting'' [6]. C-PC has several nutraceutical properties such as renoprotective (against oxalate and cisplatin, CP) [7,8], anti-inflammatory [9], and hepatoprotective (against carbon tetrachloride) [10] and others [11]. Recently, we have shown that C-PC prevents CP-induced nephrotoxicity in mice that was associated with attenuation of oxidative damage and preservation of the activity of antioxidant enzymes in kidney [2].…”

Antidiabetic potential of phycocyanin: Effects on KKAy mice

“…Small quantities are also used as biochemical tracers in immunoassays due to its fluorescent properties (Padyana et al, 2001). Furthermore, PC has proven therapeutic properties including antioxidant, anti-inflammatory, neuroprotective, hepatoprotective and anti-cancer activities (Chaiklahan et al, 2011;Eriksen, 2008;Ou et al, 2010;Pentón-Rol et al, 2011;Romay et al, 2003). However, there is little information regarding the antidiabetic activity of PC.…”

Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

“…Briefl y, the process of extraction and purifi cation included immersion, precipitation with ammonium sulfate, centrifugation, dialysis and two rounds of chromatography with hydroxyapatites (Ou et al, 2010). The absorption spectra A620/A280=4.0, The purity ratio of C-PC is defi ned as the absorption ratio of A620/A280, which the purity of food grade is 0.7 and the 4.0 reach to Reagent level (Patil et al, 2006).…”

“…Liver disease is considered to be a serious health problem (Diehl, 2002;Mann et al, 2003;Ou et al, 2010). Ethanol is a well-known hepatotoxin, and alcoholic liver disease (ALD) is caused by excessive ethanol consumption.…”