Protective Effect of Caffeic Acid Phenethyl Ester on Cyclosporine A-Induced Nephrotoxicity in Rats

Gökçe, Ahmet; Oktar, Süleyman; Yönden, Zafer; Aydın, Mehmet; İlhan, Selçuk; Özkan, Orhan Veli; Davarci, Mursel; Yalçınkaya, Fatih Rüştü

doi:10.3109/08860220903137517

Cited by 27 publications

(20 citation statements)

References 24 publications

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“…Several previous studies had suggested that cyclosporine nephrotoxicity may be improved or prevented by antioxidants. [12][13][14][15][16][17] A meta-analysis of clinical trials of CoQ10 for hypertension concluded that CoQ10 had potential for lowering blood pressure in hypertensive patients 18 ; however, in this study, no significant reduction of systolic blood pressure was observed when rCoQ10 was administered with cyclosporine. A possible explanation for this finding is that cyclosporine-induced hypertension may be caused by activation of the intrarenal renin-angiotensin axis, 7 but the renal protective effect of rCoQ10 may be accomplished by another mechanism.…”

Section: Discussioncontrasting

confidence: 60%

Effect of Reduced Form of Coenzyme Q10 on Cyclosporine Nephrotoxicity

Sato

Ishikawa²,

Homma³

2012

Exp Clin Transplant

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Objectives: Cyclosporine, a potent immunosuppressant, has nephrotoxic adverse effects that may be mediated by oxidative stress. The reduced form of coenzyme Q10 has antioxidant effects. The aim of the present study was to evaluate the effect of the reduced form of coenzyme Q10 on cyclosporine nephrotoxicity. Materials and Methods: Six-week-old male Wistar rats were divided into 3 groups (10 animals each). Group 1 (control) received olive oil only. Group 2 received cyclosporine (30 mg/kg/d, which is an experimentally nephrotoxic dose). Group 3 received cyclosporine (30 mg/kg/d) and the reduced form of coenzyme Q10 (600 mg/kg/d). The cyclosporine and the reduced form of coenzyme Q10 were given orally for 4 weeks. Daily urinary albumin excretion, serum creatinine level, and urinary 8-hydroxydeoxyguanosine level were measured, and renal tissue was evaluated by immunohis tochemistry. Results: In rats treated with cyclosporine and the reduced form of coenzyme Q10 (group 3), there were significantly less abnormalities in mean urinary albumin excretion (group 1: 2.8 ± 0.5; group 2: 41 ± 7; group 3: 21 ± 4 µg/d), serum creatinine (group 1: 1.0 ± 0.2; group 2: 1.8 ± 0.4; group 3: 1.4 ± 0.3 mg/dL), and urine 8-hydroxydeoxyguanosine levels (group 1: 7 ± 3; group 2: 10 ± 3; group 3: 7 ± 1 mg/mL creatinine) than rats treated with cyclosporine alone (group 2). There were 8-hydroxydeoxyguanosine deposits seen in the proximal tubular cells of group 2 that were not present in rats treated with the reduced form of coenzyme Q10 (group 3). Conclusions: The reduced form of coenzyme Q10 may prevent or minimize cyclosporine nephrotoxicity by an antioxidant effect.

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Section: Discussioncontrasting

confidence: 60%

Effect of Reduced Form of Coenzyme Q10 on Cyclosporine Nephrotoxicity

Sato

Ishikawa²,

Homma³

2012

Exp Clin Transplant

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“…We cannot show that how CAPE alone affects the activities of antioxidant enzymes because it was not studied. On the other hand, we have shown previously that CAPE alone may directly increase CAT activity (37). Generally, CAPE does not affect GSH-Px activitiy in normal or injured animals.…”

Section: Discussionmentioning

confidence: 65%

The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

İlhan¹,

Yılmaz²,

Nacar³

et al. 2014

Anadolu Kardiyol Derg

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Objective: The aim of this study is to investigate the effects of caffeic acid phenethyl ester (CAPE) on isoproterenol (ISO)-induced myocardial injury in hypertensive rats. Methods: Rats were divided into 4 groups (n=29):n=7) and L-NNA+ISO+CAPE (L-NNA+ISO + caffeic acid phenethyl ester) group (n=6). ISO (150 mg/kg/day) was given intraperitoneally (i.p.) once a day for 2 consecutive days (at the 12 th and 13 th days of L-NNA treatment). NG-Nitro-L-arginine (L-NNA) was given orally (25 mg/kg/ day) in drinking water for 14 days. CAPE (10 μmol/kg/day) was given (i.p.) for 7 days after the first week. Systolic blood pressure (SBP) was evaluated by the tail-cuff method and biochemical analysis were performed using an autoanalyzer and a spectrophotometer. Results: SBP in all L-NNA-treated groups was found to be increased at seventh day. AST and LDH levels in LNNA+ISO group were significantly increased compared to control (AST: 125±5 vs. 105±2; LDH: 861±154 vs. 571±46 U/L respectively) (p<0.05). Also, ISO caused to extensive necrosis and mononuclear cell infiltration in hypertensive rat myocardium. CAPE application reversed the enhanced AST and LDH levels as well as the extensive necrosis and the mononuclear cell infiltration in LNNA+ISO+CAPE group compared LNNA+ISO. Conclusion: According to our findings, it might be suggested that CAPE may be a favorable agent to protect the hypertensive myocardium from the injury induced by isoproterenol via mechanisms such as the induction of the antioxidant enzymes and the inhibition of lipid peroxidation.

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“…RCoQ10 also diminished TGF-beta expression in the proximal renal tubular cells. There are several animal and clinical studies suggesting that antioxidative agents have some preventive effect of CyA nephrotoxicity (7)(8)(9)(10)(11)(12). In 2004, Dlugosz et al reported the benefit of CoQ10 on renal transplant recipients for the first time (13); however, they used ubiquinone, the oxidized form of CoQ10.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of ubiquinol, the reduced form of coenzyme Q10, on cyclosporine nephrotoxicity

Ishikawa

Homma

2012

Int. braz j urol.

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Protective Effect of Caffeic Acid Phenethyl Ester on Cyclosporine A-Induced Nephrotoxicity in Rats

Abstract: CsA causes renal injury and CAPE prevents CAT- and lipid peroxidation-mediated nephrotoxicity via inhibition of oxidative process.

Cited by 27 publications

References 24 publications

Effect of Reduced Form of Coenzyme Q10 on Cyclosporine Nephrotoxicity

Effect of Reduced Form of Coenzyme Q10 on Cyclosporine Nephrotoxicity

The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

Beneficial effect of ubiquinol, the reduced form of coenzyme Q10, on cyclosporine nephrotoxicity

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