Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats

Ali, Azza A.; Haleem, Ekram Nemr Abd Al; Khaleel, Sahar A.; Sallam, Amany Said

doi:10.1016/j.pharep.2016.11.002

Cited by 54 publications

(36 citation statements)

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“…#### P < 0:0001 (acetic acid control vs. naïve control); * * P < 0:01; * * * P < 0:001 (acetic acid control vs. treatment group) using t test. 6 International Journal of Chronic Diseases affected by both agents in this study. Therefore, the weight loss could result from loss of body fluid through diarrhoea and bleeding.…”

Section: Discussionmentioning

confidence: 62%

“…For example, colonic changes such as mucosal ulceration, weight loss, hemorrhage, and inflammation which occur following intrarectal administration of acetic acid in rodents are also common in human IBD [18]. Also, influx of inflammatory cells such as neutrophils into the injured colon, rupture of colonic barrier, release of inflammatory mediators such as cytokines, arachidonic acid metabolites, and production of reactive oxygen species (ROS) which results in oxidative damage are common in both diseases [6]. In this study, intrarectal administration of acetic acid significantly reduced the body weight of rats.…”

Section: Discussionmentioning

confidence: 99%

“…Malondialdehyde (MDA) is a byproduct of lipid peroxidation occurring in the tissue. In ulcerative colitis, levels of MDA in the plasma increases significantly and this is used as important diagnoses of patients with inflammatory bowel disease [6]. Since lipid peroxidation occurs during oxidative stress, natural products with antioxidant activity are beneficial [28].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, conventional drugs that are commonly used in the treatment of colitis include 5-aminosalicylic acid, systemic corticosteroids, immunomodulators, and vitamin E [5]. Since excessive production of reactive oxygen species seems to play an important role in tissue damage and inflammatory process of the disease, administration of natural substances as treatment may be a valuable option for new therapies [6][7][8]. One plant of interest is Cordia vignei.…”

Section: Introductionmentioning

confidence: 99%

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Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6

Owusu

Obiri

Ainooson

et al. 2020

International Journal of Chronic Diseases

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Background. Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. Aim. In this study, we investigated the effect of hydroethanolic extract of Cordia vignei leaves (CVE) on acetic acid-induced UC in rats. Method. Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days. On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v). Rats were sacrificed on day 8 and colons were collected for histopathological examination. Blood was also collected for haematological assessment. Results. CVE significantly (P < 0.05) prevented colonic ulceration and reduced the inflammatory score. Serum levels of TNF-α and IL-6 were significantly reduced. Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced. However, loss of body weight was not significantly affected by treatment with CVE. Conclusion. This data suggest that CVE has a potential antiulcerative effect.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6

Owusu

Obiri

Ainooson

et al. 2020

International Journal of Chronic Diseases

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“…It (1-50 mg/kg) has been found to block nuclear translocation of NF-κBp65 in a mouse model of endotoxin shock, contributing to the attenuation of TNF-α, IL-6 and IL-1β secretions in LPS-induced mouse blood serum [67], and inhibit NF-κB DNA-binding in LPS-stimulated macrophage cells [68]. In acetic acidinduced colitis model, cardamonin (10 or 30 mg/kg) treatment ameliorates the disease activity index (DAI) and macroscopic damage index scores, and reduces the levels of NF-κB and TNF-α as well as oxidative stress and apoptosis, evidencing it has a protective effect against acetic acid-induced colitis [69].…”

Section: Interior-warming and Drying Dampness Medicinementioning

confidence: 99%

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Zhao

2020

Chin Med

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Nuclear factor-kappa B (NF-κB) is a kind of multi-functional nuclear transcription factor involved in regulating gene transcription to influence pathological evolution of inflammatory and immune diseases. Numerous literature evidence that NF-κB pathway plays an essential role in pathogenic development of ulcerative colitis (UC). UC is a chronic non-specific inflammatory bowel disease, and until now, therapeutic agents for UC including aminosalicylates, corticosteroids and immune inhibitors still cannot exert satisfied effects on patients. In recent years, Chinese medicines suggest the advantages of alleviating symptoms and signs, decreasing side-effects and recurrence, whose one of mechanisms is related to regulation of NF-κB pathway. In this review, we categorize Chinese medicines according to their traditional therapeutic functions, and summarize the characteristics of Chinese medicines targeting NF-κB pathway in UC treatment. It indicates that 85 kinds of Chinese medicines' compounds and formulae can directly act on NF-κBp65; while 58 Chinese medicines' ingredients and formulae indirectly suppress NF-κBp65 by regulation of its upstream or other related pathways. Moreover, by the analysis of Chinese medicines' category based on their traditional functions, we conclude the category of dampness-drying and detoxificating medicine targeting NF-κB pathway accounts for primary status for amelioration of UC. Simultaneously, this review also contributes to the choices of Chinese medicine category and provides curative potential of Chinese medicines for clinical UC treatment.

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Dimethyl Cardamonin from Fruits of Campomanesia reitziana D. Legrand Promotes Gastroprotection and Gastric Healing Effects in Rodents

Cury

Boeing

Somensi

et al. 2022

Chemistry & Biodiversity

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Campomanesia reitziana D. Legrand (Myrtaceae) displays antiulcer properties when given to rodents. The major active chemical components of C. reitziana are chalcones, including 4',6'-dihydroxy-2'-methoxy-3',5'dimethylchalcone or dimethyl cardamonin (DMC); therefore, we hypothesized that this compound could have antiulcer effects and the present study aimed to evaluate its gastroprotective and gastric healing properties. DMC was isolated from the fruits of C. reitziana, and its gastroprotective effect was evaluated by ethanol and indomethacin-induced gastric ulcer models in mice (0.1 mg/kg, i.p. and 1 and 3 mg/kg, p.o.). Oxidative stress and inflammatory parameters were analyzed in the gastric tissue. Moreover, its gastric healing effect was evaluated in rats. In addition, the compound's mode of action was evaluated in vivo and in vitro by measuring H + -K + -ATPase activity. Finally, the cytotoxic potential of DMC was tested in fibroblasts and human gastric adenocarcinoma cells. The DMC reduced the ethanol-induced gastric ulcer in mice by 77 %, increased the adhered mucus, and reduced lipoperoxides levels. The block of nonprotein sulfhydryls (NP-SH) compounds by pretreatment with N-ethylmaleimide (NEM), the inhibition of nitric oxide synthase with Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), or the antagonism of α 2 receptor using yohimbine reversed the gastroprotective effects of DMC. Furthermore, DMC reduced the acidity of gastric content in pylorus-ligated rats but did not change H + , K + -ATPase (isolated from rabbit) activity in vitro. DMC reduced the lesion area in acetic acid-induced ulcers and decreased myeloperoxidase activity. DMC did not change the viability of fibroblast cells (L929) but reduced the viability of human gastric adenocarcinoma cells (AGS). The results confirmed that DMC could significantly enhance the gastric healing process and prevent ulcers due to improving protective factors on the gastric mucosa and reducing gastric acid secretion.

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Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats

Abstract: Cardamonin has a protective effect against acetic acid-induced colitis. This effect may be due to reducing inflammation, oxidative stress and apoptosis.

Cited by 54 publications

References 46 publications

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6

Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract ofCordia vigneiLeaves through Reduced Serum Levels of TNF-αand IL-6

Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines

Dimethyl Cardamonin from Fruits of Campomanesia reitziana D. Legrand Promotes Gastroprotection and Gastric Healing Effects in Rodents

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