Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

“…Our results were in line with the previous study that BPA administration to rats (0.5 mg·kg −1 ·day −1 , gavage, for 30 days) had no effects on the body weight but increased TC and LDL-C (Hassani et al, 2017).…”

“…Previous studies showed hyperglycemic effects of BPA both in rat (Hassani, Mehri et al, 2017) and mice (Moghaddam et al, 2015). Oxidative stress, inflammation (Pahlavani et al, 2017), and insulin resistance, which are seen in diabetes or metabolic syndrome, is accompanied with impaired insulin-stimulated proteins (PI3K and p-Akt; da Costa et al, 2017).…”

“…It is important to notice that this GSE polyphenols has been standardized according to gallic acid (equals to 176 mg of gallic acid in 1 g of deride extract), and based on the HPLC method, its identified antioxidant compounds were gallic acid, ellagic acid, epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin, and their derivatives (Rameshrad, Imenshahidi, Razavi, Iranshahi, & Hosseinzadeh, 2018 Animals were treated once daily (around 11 a.m. to 14 p.m.), for 2 months on a normal diet. The solvents and dose selections were selected according to references (Rameshrad et al, 2018;Hassani et al,, 2017). The doses were adjusted according to the mean of animals' body weight in each group, weekly.…”

“…Western blotting was performed for evaluating the effect of tested compounds on the protein expression of Akt and PI3K, as previously described with minor modifications (Hassani et al, 2017). Tris-base, 10% V/V 2-ME, 4% W/V SDS, 20% V/V glycerol, and 02% W/V bromophenol blue) at equal volume and subsequently incubated in boiling water for 5 min.…”

Clinical and metabolic responses to crocin in patients under methadone maintenance treatment: A randomized clinical trial

“…It has also been demonstrated that crocin reduces DNA damage and cell necrosis and prevents the death of PC‐12 cells through sphingomyelinase‐ceramide signaling by enhancing glutathione synthesis (H. Hosseinzadeh, Abootorabi, & Sadeghnia, ; Ochiai et al, ). In addition, several reports showed that crocin has different properties on clinical and metabolic disturbance including increases in mRNA and brain‐derived neurotrophic factor, protein status of VGF neuropeptide, cAMP response element binding (Dorri et al, ; Razavi et al, ), downregulation of mitogen‐activated protein kinase, mitogen‐activated protein kinase‐activated protein signaling pathway, miRNA‐122 expression (Vahdati Hassani, Mehri, Abnous, Birner‐Gruenberger, & Hosseinzadeh, ), inhibiting apoptosis (Razavi, Hosseinzadeh, Abnous, Khoei, & Imenshahidi, ), decreased TNF‐α and IL‐6 levels in striatum (L. Mohammadzadeh, Hosseinzadeh, Abnous, & Razavi, ), modulates IL‐4/IL‐13 signaling (Yosri, Elkashef, Said, & Gameil, ), inhibiting TAU protein hyperphosphorylation, and antiapoptotic effects (Leila Mohammadzadeh, Abnous, Razavi, & Hosseinzadeh, ), alteration of gene expression profile of T24 (transitional cell carcinoma of bladder) cell (Lv, Luo, Ji, & Zhao, ), and regulate the expression of Bcl‐2 with simultaneous up regulation of pro apoptotic Bax in MCF‐7 cells (Bakshi, Hakkim, & Sam, ).…”