Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

Jalili, Cyrus; Khani, Fuzie; Salahshoor, Mohammad Reza; Roshankhah, Shiva

doi:10.4067/s0717-95022014000300017

Cited by 35 publications

(58 citation statements)

References 24 publications

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“…The abstracted cauda epididymides wer transferred into a Petri dish containing DMEM/F12 (Gibco-Cat.32500-05) and were incubated at 37°C , CO 2 (5 %) for 7 minutes (Jalili et al, 2014). Fifty ml of the culture medium containing semen liquid was removed and placed on glass slide, and sperm motility was evaluated by a light microscope with a magnification of 40× in ten vision fields based on WHO procedure.…”

Section: Methodsmentioning

confidence: 99%

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Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

et al. 2017

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JALILI, C.; SALAHSHOOR, M. R. ; JALILI, F; KAKABARAEI, S.; AKRAMI, A.; SOHRABI, M.; AHOOKHASH, M. & GHANBARI, A.Therapeutic effect of resveratrol on morphine-induced damage in male reproductive system of mice by reducing nitric oxide serum level. Int. J. Morphol., 35(4):1342Morphol., 35(4): -1347Morphol., 35(4): , 2017. SUMMARY:Morphine is one of the naturally occurring phenanthrene alkaloids of opium that induces adverse effects on male reproductive system. Resveratrol is a phytoestrogen and antioxidant of red grape. The main goal is to investigate whether resveratrol could inhibit adverse effects of morphine on sperm cell viability, count, motility as well as testis histology, testosterone hormone and nitric oxide levels in mice. In the present study, 48 male rats were randomly divided into 8 groups (n=6) and were treated intraperitoneally for 14 days with normal saline, resveratrol (2, 8, 20 mg/kg/day), morphine (20 mg/kg/day) and morphine (20 mg/kg/day) + resveratrol (2, 8, 20 mg/kg/day). At the end of experiments, sperm parameters (sperm cell viability, count, motility and morphology), testis weight, the diameter of seminiferous tubules, testosterone hormone level and nitric oxide were analyzed. The data were analyzed by SPSS software for windows (version 20) using one-way ANOVA test followed by Tukey's post hoc test, and P<0.05 was considered significant. The results indicated that morphine administration significantly decreased testosterone level, count, viability and motility of sperm cells and testis weight and increased nitric oxide compared to the saline group (P=0.000). Administration of resveratrol and resveratrol plus morphine significantly increased motility, count and viability of sperm cells, somniferous tubule diameter and testosterone, while it decreased nitric oxide level compared to morphine group (P=0.025). It seems that resveratrol administration could increase the quality of spermatozoa and prevented morphine-induced adverse effects on sperm parameters.

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Section: Methodsmentioning

confidence: 99%

“…Studies have shown the existence of morphine receptors in sertoli and leydig cells of testis and have further addressed the involvement of inflammation and oxidation during male reproductive system exposure to morphine by producing NO and regulating inflammatory cascades (Jalili et al, 2016;Chehrei et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

et al. 2017

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“…Once the photo was prepared, the number of cells was counted per 1 mm 2 area. On the slides, stained by means of Cresyl violet technique, the round cells without peak nose were considered as live cells 19 .…”

Section: Cresyl Violet Methodsmentioning

confidence: 99%

Toxicological evaluation of the nicotine on CA1 and protective effects of curcuma longa: An experimental study

et al. 2019

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Introduction: Nicotine is the most important alkaloid compound in tobacco and is a major risk factor in the development of functional disorders of several organ systems. Some plants produce Curcuma longa (curcumin), which has antioxidant and neuro-protective properties. Methods: This study was designed to evaluate the therapeutic effects of curcumin against nicotine injury on the hippocampus CA1 region of rats. In this study, 48 male rats were randomly assigned to eight groups: Normal control (saline) group, Nicotine control group (0.5 mg/kg); Curcumin groups (10, 30, and 60 mg/kg) and Nicotine + Curcumin groups (10, 30, and 60 mg/kg). Treatments were administered intra-peritoneally daily for 28 days. Golgi staining technique investigated the number of dendritic spines. Cresyl violet staining method was used to determine the number of neurons in the hippocampal region CA1. Griess technique was assessed to determine serum nitrite oxide levels. Also, the ferric reducing/antioxidant power (FRAP) method was applied to determine the total antioxidant capacity. Results: Nicotine administration significantly increased the nitrite oxide level and decreased total antioxidant capacity. The number of neuronal dendritic spines, as well as neurons per se, also decreased, compared to the control group (p < 0.01). In all the members of the Curcumin and Nicotine + Curcumin groups, the number of neurons, neuronal dendritic spines and total antioxidant capacity increased significantly compared to the nicotine control group, while nitrite oxide level decreased significantly compared to the nicotine control group (p < 0.01). Conclusions: It seems that Curcumin administration improved hippocampal CA1 region injury in rats caused by Nicotine.

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“…Nowadays, m edicinal plants hav e num erous applications and one of t he t arget tissues f or plant extrac ts is r eproductiv e organs s uc h as t estis and sperm paramet ers (Jalili et al, 2014) In t he herein s tud y, mic e co-administr at ed with c urc umin s howed ultrastr uct ural feat ures clos e to t hat of normal testic ular archit ect ure. Curc umin w as ass umed to increases the count and m otilit y of norm al sperms i n tr eat ed groups t hrough enhanci ng t he anti -oxid ant def ense of the body (V alko et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

The Potential Ameliorative Effect of Curcumin in Schistosoma Mansoni Infected Mice: An Ultrstructural Study on the Testes

Mira¹

2017

Egypt. J. Exp. Biol. (Zoo.)

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N ab i l a Mous a Mi r aT he potential ameli orativ e effect of curcu min i n Sc histoso ma mansoni infecte d mic e: an ultrastru ctural study on the testes ABSTRACT:This inves tigation has been designed t o eval uate the antibilharzial ef ficienc y and th e possible amelior ativ e r ole of c urc umin on adult m ale Swiss albino mic e tes tes . T hirt y anim als were us ed in t his experiment , divided equall y into 3 groups: group 1, c ontr ol group; group 2, inf ect ed with S. mans oni, and group 3, infec ted mice treat ed with c urcumin.Ultrastruc tur e examinati on was perform ed on the tes tes usi ng transmissi on electron microscop y (TE M). R es ults i ndicat ed that the test es in t he inf ec ted group s howed thick eni ng and irregul arit y i n t he s urrounding basal l amina, c yt oplasmic vac uolat i on of atrophi ed Sert oli c ells, shrinkage and p yk notic nucl ei of spermat ogonia , as w ell as primar y spermat oc yt es, especiall y i n fr ont of t he s ex vesicles . Furt hermore, S ertoli c ells c ont ai ned various f orms of mitoc hondrial d egeneration and wide int ercell ul ar sp aces of adherent juncti on am ong the S ertoli, as w ell as spermat ogenic c ells. B esides, m ost of sperms were mark edly aff ect ed. Supplement ati on of curcumi n minimized the degener ativ e chang es in t he nucl ear envel ope and sex v esicles of the primar y spermat oc yte nucl ei besides narrowi ng the adherent juncti on among S ertoli cells and germ c ells. In c onclusi on, c urcumi n proved to hav e a pot ential rol e i n minimizing the deleteri ous ef fec t of S. m ansoni in t est es of t he infec ted mic e. KEY WORDS:Schis tos oma mans oni, Swiss albino mice, test es, curc umin, ultr astr uct ure

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Protective Effect of Curcumin Against Nicotine-induced Damage on Reproductive Parameters in Male Mice

Cited by 35 publications

References 24 publications

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level

Toxicological evaluation of the nicotine on CA1 and protective effects of curcuma longa: An experimental study

The Potential Ameliorative Effect of Curcumin in Schistosoma Mansoni Infected Mice: An Ultrstructural Study on the Testes

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