Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat

Mohammed, Haitham S.; Hosny, Eman N; Khadrawy, Yasser A.; Magdy, Merna; Attia, Yasmen S.; Sayed, Omnia A.; Abdelaal, Mohamed M.

doi:10.1016/j.bbadis.2020.165665

Cited by 50 publications

(47 citation statements)

References 45 publications

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“…Angiotensin-converting enzyme (ACE) inhibitors, including enalapril, zofenopril, and lisinopril is another strategy that has been evaluated to prevent cardiomyopathy [43]. Involvement of natural bioactive compounds have been used to prevent or alleviate DOX-induced cardiomyopathy, including thymoquinone [44], luteolin [45], dioscin [46], curcumin [47,48], and others. In the current study, COS and COS-NPs alleviated the cardiotoxicity associated with DOX therapy in the xenograft model.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Nanonutraceuticals: Anti-Cancer Activity and Improved Safety of Chemotherapy by Costunolide and Its Nanoformulation against Colon and Breast Cancer

et al. 2021

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Costunolide (COS) is a sesquiterpene lactone with anticancer properties. The present study investigated the anticancer effects of COS against the human colon (HCT116) and breast (MDA-MB-231-Luc) cancer cell lines. Inhibition of cell lines viability and IC50 of COS were assessed via an MTT assay. Furthermore, the apoptotic rate was detected by assessment of Bcl2-associated X (Bax) and B-cell lymphoma 2 (Bcl2) protein levels by flow cytometry. Xenograft mice model of HCT116 and MDA-MB-231-Luc were carried out to determine the effect of COS and its nanoparticles (COS-NPs). The results demonstrated that COS inhibited the viability of HCT116 and MDA-MB-231-Luc cells, with a half maximal inhibitory concentration value (IC50) of 39.92 µM and 100.57 µM, respectively. COS significantly increased Bax and decreased Bcl2 levels in treated cells. COS and COS-NPs, in combination with doxorubicin (DOX), significantly decreased the tumor growth of HCT116 and MDA-MB-231-Luc implants in mice. Furthermore, oral administration of COS and COS-NPs significantly decreased the viable cells and increased necrotic/apoptotic cells of HCT116 and MDA-MB-231-Luc implants. Interestingly, both COS and COS-NPs protected the cardiac muscles against DOX’s cardiotoxicity. The current results indicated the promising anticancer and cardiac muscles protection of COS and COS-NPs when administered with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Nanonutraceuticals: Anti-Cancer Activity and Improved Safety of Chemotherapy by Costunolide and Its Nanoformulation against Colon and Breast Cancer

et al. 2021

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“…Mesoporous silica nanoparticles (MSNs) significantly promote bioavailability of curcumin that is beneficial for decreasing oxidative damage and reinforcing the antioxidant defense system by enhancing activities of SOD, CAT and GSH [166]. According to the fact that poor bioavailability of curcumin is a barrier for its therapeutic effects, loading curcumin on nanoparticles remarkably promotes its bioavailability that is of importance for preventing DOX-mediated cardiotoxicity [167]. It is held that enhancing ROS overgeneration by DOX leads to the stimulation of mitochondrial pathway of apoptosis.…”

Section: Impact On Adverse Effectsmentioning

confidence: 99%

“…Simultaneous treatment of cardiomyocytes with curcumin and DOX potentiates cardiotoxicity of DOX, while pretreatment with curcumin is of importance in repressing DOX-mediated cardiotoxicity [168]. So, time, dose and mode of treatment are important for cardioprotective activity of curcumin and using nanoparticles significantly promotes therapeutic efficacy of curcumin [167].…”

Section: Impact On Adverse Effectsmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

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“…Doxorubicin is an anthracycline-containing quinone, which binds to cardiolipin in the mitochondria of cardiomyocytes. Its quinone part produces reactive oxygen species (ROS) through redox reaction in mitochondrial electron transport chain complex1 (Mohammed et al, 2020;Sheibani et al, 2020). Doxorubicin could combine with iron to form Fe3 + doxorubicin complex, which led to the deactivation of cytochrome c oxidase and changed the iron homeostasis process related to aconitase-ferritin-1.…”

Section: Discussionmentioning

confidence: 99%

“…Doxorubicin could combine with iron to form Fe3 + doxorubicin complex, which led to the deactivation of cytochrome c oxidase and changed the iron homeostasis process related to aconitase-ferritin-1. Cytochrome c is an important part of the electron transport chain, and the reduction of its activity mediates the production of free radicals (Mohammed et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis

et al. 2021

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The purpose of this study was to evaluate the protective effect of acidic fibroblast growth factor targeted mediated by novel nanoparticles–cationic lipid microbubbles complex (aFGF–NP + CPMBs) combined with ultrasound targeted microbubble destruction (UTMD)on doxorubicin–induced heart failure (HF)and its mechanism. Heart failure rats induced by intraperitoneal injection with doxorubicin (DOX) to achieve cummulative dose of 15mg/kg for continuous 6 weeks showed left ventricular dysfunction, seriously oxidative stress, cardiomyocyte apoptosis, and decrease of myocardial vascular density. In contrast, aFGF–NP + CPMBs combined with UTMD therapy (3ug/kg, caudal vein injection, twice a week, 6weeks)prominently ameliorated left ventricular dysfunction by increased ejection fraction (EF) and fractional shortening (FS), decreased brain natriuretic peptide (BNP); strengthened the ability of antioxidant stress confirmed by increasing the activity of SOD and reducing the production of MDA; exerted the effect of anti–cardiomyocyte apoptosis and promotion angiogenesis by inhibited Bax expression and increased Bcl–2 expression and platelet endothelial cell adhesion molecule (CD31) expression. Taken together, the research suggested that aFGF targeted mediated by novel nanoparticles–cationic lipid microbubbles complex combined with UTMD should be a promising targeted treatment for heart failure.

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Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat

Cited by 50 publications

References 45 publications

RETRACTED: Nanonutraceuticals: Anti-Cancer Activity and Improved Safety of Chemotherapy by Costunolide and Its Nanoformulation against Colon and Breast Cancer

RETRACTED: Nanonutraceuticals: Anti-Cancer Activity and Improved Safety of Chemotherapy by Costunolide and Its Nanoformulation against Colon and Breast Cancer

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis

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