Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats

Gali, Sreevarsha; Sharma, Swati; Kundu, Amit; Lee, Eunah; Han, Joo Hee; Shin, Joo Kyung; Choi, Ji Soo; Kyung, So Young; Kim, Jae-Sung; Kim, Hyung Sik

doi:10.1080/15376516.2023.2171824

Cited by 4 publications

(1 citation statement)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in liver function upon acute or chronic exposure to toxicants have been reported (Gali et al 2023). Parameters such as ALP, ALT, AST, and LDH are indicators of liver damage.…”

Section: Discussionmentioning

confidence: 99%

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Apaydın

Kalender

Baş

et al. 2023

Preprint

View full text Add to dashboard Cite

Fenitrothion (FNT) is a known environmental contaminant used in public health and agriculture. Gallic acid (GA) is a phenolic compound found in numerous plants. This study analyzed the hepatotoxic and nephrotoxic effects of FNT and to evaluate the possible protective effect of gallic acid. FNT (1/25 LD50, 32 mg/kg body weight/day), and gallic acid (50 mg/kg body weight/day) were administrated to male rats by gavage for 28 days. In the present study, the renal (blood urea nitrogen, creatinine and uric acid levels) and liver (albumin, total protein, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, lactate dehydrogenase) function markers in the blood, acetylcholinesterase activities, antioxidant enzyme activities and malondialdehyde level as markers of oxidative stress, and histopathological changes were researched in liver and kidney tissues. Additionally, while superoxide dismutase, catalase, glutathione-S-transferase and glutathione peroxidase activities were decreased in the liver and kidney tissue of rats treated with fenitrothion, malondialdehyde level was significantly increased. Histopathological analyses showed many injuries occurred in the renal and hepatic tissue of fenitrothion-treated animals. Also, the supplementation of gallic acid with fenitrothion significantly improved fenitrothion-induced alterations in renal and liver function markers, antioxidant enzyme activities, acetylcholinesterase activities malondialdehyde levels, and histological features of tissues.

show abstract

“…Changes in liver function upon acute or chronic exposure to toxicants have been reported (Gali et al 2023). Parameters such as ALP, ALT, AST, and LDH are indicators of liver damage.…”

Section: Discussionmentioning

confidence: 99%

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Apaydın

Kalender

Baş

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats

Sengul,

Yildirim,

Cinar

et al. 2024

Biol Trace Elem Res

View full text Add to dashboard Cite

Cadmium (Cd) is a toxic heavy metal with significant environmental health hazards. It enters the body through various routes with tissue accumulation. The relatively longer half-life with slow body clearance significantly results in hepatotoxicity during its liver detoxification. Therefore, researchers are exploring the potential use of herbal-derived phytocomponents to mitigate their toxicity. Here, we investigated, for the first time, the possible ameliorative effect of the phytochemical Morin (3,5,7,29,49-pentahydroxyflavone) against acute Cd-induced hepatotoxicity while resolving its underlying cellular mechanisms in a rat animal model. The study involved 50 adult male Sprague–Dawley rats weighing 200–250 g. The animals were divided into five equal groups: control, Cd, Morin100 + Cd, Morin200 + Cd, and Morin200. The 2nd, 3rd, and 4th groups were intraperitoneally treated with Cd (6.5 mg/kg), while the 3rd, 4th, and 5th groups were orally treated with Morin (100 and 200 mg/kg) for 5 consecutive days. On the 6th day, hepatic function (serum ALT, AST, ALP, LDH enzyme activities, and total bilirubin level) testing, transcriptome analysis, and immunohistochemistry were performed to elucidate the ameliorative effect of Morin on hepatotoxicity. In addition to restoring liver function and tissue injury, Morin alleviated Cd-induced hepatic oxidative/endoplasmic reticulum stress in a dose-dependent manner, as revealed by upregulating the expression of antioxidants (SOD, GSH, Gpx, CAT, and Nrf2) and decreasing the expression of ER stress markers. The expression of the proinflammatory mediators (TNF-α, IL-1-β, and IL-6) was also downregulated while improving the anti-inflammatory (IL-10 and IL-4) expression levels. Morin further slowed the apoptotic cascades by deregulating the expression of pro-apoptotic Bax and Caspase 12 markers concomitant with an increase in anti-apoptotic Blc2 mRNA expression. Furthermore, Morin restored Cd-induced tissue damage and markedly suppressed the cytoplasmic expression of JNK and p-PERK immunostained proteins. This study demonstrated the dose-dependent antioxidant hepatoprotective effect of Morin against acute hepatic Cd intoxication. This effect is likely linked with the modulation of upstream p-GRP78/PERK/ATF6 pro-apoptotic oxidative/ER stress and the downstream JNK/BAX/caspase 12 apoptotic signaling pathways.

show abstract

Cross-talk between Vimentin and autophagy regulates blood-testis barrier disruption induced by cadmium

Chen,

Wan,

Wang

et al. 2024

Environmental Pollution

View full text Add to dashboard Cite

Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats

Cited by 4 publications

References 78 publications

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats

Cross-talk between Vimentin and autophagy regulates blood-testis barrier disruption induced by cadmium

Contact Info

Product

Resources

About