Protective effect of edaravone against the ototoxicity ofPseudomonas aeruginosaexotoxin A

Abstract

PaExoA had penetrated from the middle ear into the cochlea and caused hearing loss. This impairment was blocked by intratympanic injection of edaravone when given simultaneously or 1 h after the first instillation of PaExoA, or by intravenous injection of edaravone when given simultaneously. There were significant differences in protective effect between the intratympanic and intravenous routes.

Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line

“…Although edaravone is rather a safe agent when administered to the patients (Takumida and Anniko, 2006), its clinical application in cisplatin-induced ototoxicity remains unclear, because the problem as to whether edaravone enhances or suppresses the efficacy of cisplatin in the treatment of cancer cells remains unsettled yet. Also, since our experiment was conducted with an HEI-OC1 cell line, its conditions are not typical condition of cochlear cells as it is cultured under permissive conditions (33.8 C, 10% CO2).…”

“…Edaravone is a neuroprotective agent with potent free radical scavenging and antioxidant actions without causing any serious side effects (Takumida and Anniko, 2006;Higashi et al, 2006). Edaravone is reported to reduce the amount of oxidative DNA damage (Maekawa et al, 2009) and decrease the amount of ROS Fig.…”

“…and inhibits oxidation. It is assumed that edaravone inhibits lipoxygenase metabolism by trapping hydroxyl radicals, prevents peroxidation, and enhances of prostacyclin production (Takumida and Anniko, 2006;Watanabe et al, 1988).…”

Protective effect of edaravone against tobramycin-induced ototoxicity

“…ROS scavengers have been shown to protect the inner ear from the deleterious effects of aminoglycosides [6], cisplatin [7], bacterial toxin [8], and acoustic trauma [9]. There is accumulating research evidence that the free radicals may play an important role in the inner ear and antioxidants can be used not only for the prevention of but also for treatment of inner ear disorders [10].…”

Effects of caffeic acid on cisplatin-induced hair cell damage in HEI-OC1 auditory cells

“…The generation of ROS is an important mechanism of inner ear damage and ototoxicity [1,16,19]. An excess of ROS can induce apoptotic cell death.…”