Protective Effect of Erdosteine Against Hypochlorous Acid-induced Acute Lung Injury and Lipopolysaccharide-induced Neutrophilic Lung Inflammation in Mice

Abstract

The effect of erdosteine, a mucoactive drug, on hypochlorous acid (HOCl)-induced lung injury, and the lipopolysaccharide (LPS)-induced increase in tumour necrosis factor-alpha (TNF-alpha) production and neutrophil recruitment into the airway, was investigated. Male BALB/c mice were orally administered erdosteine (3-100 mgkg(-1)), ambroxol hydrochloride (ambroxol) (3-30 mgkg(-1)), S-carboxymethyl-L-cysteine (S-CMC) (100-600 mgkg(-1)) or prednisolone (10 mgkg(-1)), 1 h before intratracheal injection of HOCl or LPS. In the HOCl-injected mice, erdosteine markedly suppressed increases in the ratios of lung wet weight to bodyweight and lung dry weight to bodyweight, whereas the other mucoactive drugs ambroxol and S-CMC had little effect. Erdosteine also inhibited the LPS-induced neutrophil influx, although it did not affect the increased level of TNF-alpha in the bronchoalveolar lavage fluid. The results suggest that attenuation of reactive oxygen species and neutrophil recruitment is involved in the clinical efficacy of erdosteine in the treatment of chronic bronchitis.

Cisplatin‐induced acute renal failure is ameliorated by erdosteine in a dose‐dependent manner

“…These findings indicate the potent free-radical scavenger properties of erdosteine reported in many previous studies (Hayashi et al, 2000; et al., 1991). The most common side-effect of this group of drugs (such as N-acetylcysteine) is gastric mucosa irritation due to the mucolytic affect, and this side-effect is rarely seen in erdosteine because the mucolytic effect of erdosteine emerges after hepatic metabolism (Giovanni et al, 1991).…”

Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats

“…The activated T lymphocytes release cytokines including IL-2, IL-4 and IL-6, which participate in B lymphocyte activation. It has been reported that TNF-a levels in the serum, BALF and lung homogenate were increased in CB animals and patients [20,21]. The increased TNF-a could enhance T, B lymphocyte and AM reciprocity and exacerbate inflammation.…”

Erdosteine Improves Oxidative Damage in a Rat Model of Renal Ischemia-Reperfusion Injury

“…According to our results, treating rats with erdosteine attenuated the increase in the tissue levels of MPO and MDA caused by the I/R condition. Hayashi et al [17] reported that erdosteine inhibited neutrophil infiltration in mice intratracheally treated with LPS. In addition, it has been suggested that erdosteine exhibits antioxidant properties by blocking production of ROS in human neutrophils and suppresses the oxidative burst of human polymorphonuclear leukocytes [3].…”