2007
DOI: 10.1007/s00011-006-5185-0
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Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf on inflammatory cytokine and mediator induction from alveolar macrophages of chronic bronchitic rats

Abstract: TAL inhibited NF-kB activation in AM from CB rats and led to down regulation of TNF-alpha, IL-1, PGE(2) and LTB(4) expression, which might be a mechanism for its anti-inflammatory effects in CB rats.

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Cited by 28 publications
(18 citation statements)
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“…A variety of drugs used to treat human inflammatory diseases had effects on TNF-␣ (Tak and Firestein, 2001;Huang et al, 2006). It has been shown that during the process of bleomycin-induced pulmonary fibrosis sudden inflammatory responses are produced leading to an increase in the number of macrophages, which induce inflammatory cells in the injured tissue to produce cytokines (Phan and Kunkel, 1992;Kuroki et al, 2003;Huang et al, 2006Huang et al, , 2007Huang et al, , 2009). These cytokines have been linked to airway fibrosis because of their ability to regulate fibroblast and matrix production (Elias et al, 1999).…”
Section: Discussionmentioning
confidence: 98%
“…A variety of drugs used to treat human inflammatory diseases had effects on TNF-␣ (Tak and Firestein, 2001;Huang et al, 2006). It has been shown that during the process of bleomycin-induced pulmonary fibrosis sudden inflammatory responses are produced leading to an increase in the number of macrophages, which induce inflammatory cells in the injured tissue to produce cytokines (Phan and Kunkel, 1992;Kuroki et al, 2003;Huang et al, 2006Huang et al, , 2007Huang et al, , 2009). These cytokines have been linked to airway fibrosis because of their ability to regulate fibroblast and matrix production (Elias et al, 1999).…”
Section: Discussionmentioning
confidence: 98%
“…Lipopolysaccharide (LPS)-induced inflammation is a common experimental model for anti-inflammatory research. Loquat leaf extracts enriched with triterpene acids, especially ursolic acid ( 1 ), showed anti-inflammatory effects on alveolar macrophages in rats with LPS-induced CB [7,8,14,15]. Twelve triterpene acids, e.g., seven ursane-type [ursolic acid ( 1 ), corosolic acid ( 2 ), 3- O - cis - p -coumaroyltormentic acid ( 3 ), 3- O - trans - p -coumaroyltormentic acid ( 4 ), 3-epicorosolic acid ( 5 ), euscaphic acid ( 6 ), 1β-hydroxyeuscaphic acid ( 7 )], four oleanane-type [oleanolic acid ( 8 ), maslinic acid ( 9 ), methyl arjunolate ( 10 ), 2α,3α,23-trihydroxyolean-12-en-28-oic acid ( 11 )], and one lupane-type [betulinic acid ( 12 )] isolated from the ethyl acetate-soluble fraction of loquat leaf showed marked anti-inflammatory effects in the inhibition of 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced ear edema of mice, and the 50% inhibitory dose of these twelve compounds ranged from 0.03–0.43 mg per ear (Figure 1) [6].…”
Section: Bioactivities Of Loquat Extractsmentioning
confidence: 99%
“…Increased levels of inducible nitric synthase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) have been correlated with inflammation [8,14,18]. Therefore, decreasing pro-inflammatory mediators (such as iNOS, COX-2, TNF-α, IL-6, IL-8, IL-1β) and/or increasing anti-inflammatory cytokine (such as IL-10) secretions are important mechanisms for the anti-inflammation effects of loquat extracts [8,13,14,18,19,20,21].…”
Section: Bioactivities Of Loquat Extractsmentioning
confidence: 99%
“…비파 잎에는 다양한 terpenoid (Nazato et al 1984)와 플라보노이드 (Jung et al 1999 (Nazato et al 1994;Jung et al 1994;Taniguchi et al 2002). 이 밖에도 비파 잎, 씨 또는 과육에 다량 함유되어 있는 유용한 화합물들의 항산화효과 (Jung et al 1994;Koba et al 2007;Lee et al 2009), 항 당뇨효과 (Chen et al 2008), 항염증 및 항암효과 Banno et al 2005;Huang et al 2007), 항바이러스효과 (De Tommasi et al 1992 Seedless fruit.…”
Section: 서론unclassified