Protective effect of Eruca sativa seed oil against oral nicotine induced testicular damage in rats

El-Aziz, Gamal S. Abd; El-Fark, Magdy O.; Hamdy, Raid M.

doi:10.1016/j.tice.2016.05.006

Cited by 17 publications

(8 citation statements)

References 32 publications

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“…We found marked decreased serum testosterone concentrations and epididymal sperm density in the nicotine treated group. This finding was also in agreement with previous studies [4,9,10,30]. However, co-treatment with ICA reversed these trends.…”

Section: Discussionsupporting

confidence: 94%

Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse –a pilot study

Zhang

Afedo

et al. 2020

Reprod Biol Endocrinol

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Background: Nicotine, a pharmacologically active component of tobacco adversely affects the male reproductive system and fertility whereas icariin (ICA), the main active ingredient in Epimedium herba has been used in the treatment of several male reproductive problems. This study aimed at evaluating the protective or ameliorative effect of ICA against reproductive toxicity induced by intraperitoneal injection of nicotine in mice. Methods: Using simple random allocation, forty male mice were randomly divided into 4 groups: control (received 0.35 mL physiological saline via gastric gavage), nicotine (0.75 mg/kg BW/day intraperitoneally), ICA (75 mg/kg BW/ day gastric gavage), and nicotine plus ICA (nicotine, 0.75 mg/kg BW/day intraperitoneally + ICA, 75 mg/kg BW/day gastric gavage) group. After 35 days of treatment, the mice were weighed, sacrificed, and their reproductive organs (testis and epididymis) were collected and examined for further studies. Results: The nicotine-treated group showed significantly decreased epididymal sperm density and serum testosterone concentration relative to the control group. Nicotine also caused oxidative damage shown by significant reduction in the activities of antioxidant enzymes and elevation in Malondialdehyde (MDA) levels. ICA on the other hand, improved the reduction in sperm density, hormone levels, and activities of antioxidant enzymes altered in the nicotine treated mice. Conclusions: These findings indicate that nicotine-induced reproductive toxicity and oxidative damage on male reproductive tissues could be attenuated by ICA.

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Section: Discussionsupporting

confidence: 94%

Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse –a pilot study

Zhang

Afedo

et al. 2020

Reprod Biol Endocrinol

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“…Both Eruca leaves and seeds have aphrodisiac effect. In seeds, the aphrodisiac effect may be attributed to desulfoglucosinolates, erucic acid, and an essential oil that is rich in isothiocyanates or to a combination of these phytochemicals [78].…”

Section: Effect On Fertilitymentioning

confidence: 99%

Eruca Sativa Linn.: Pharmacognostical and Pharmacological Properties and Pharmaceutical Preparations

Jaafar

Jaafar²

2019

Asian J Pharm Clin Res

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Eruca sativa (jarjeer) is an annual herb (family Brassicaceae), which contains a wide range of chemicals and minerals with nutraceutical and organoleptic characteristics. Jarjeer was generally used as a food and traditionally mainly consumed due to its aphrodisiac properties. This crop known to contain various phytochemicals such as flavonoids, phenolic acids, terpens, carotenoids, tannins, glycosides, saponins, sterols, alkaloids, and other secondary metabolites. In leaves, kaempferol and its derivatives, glucosativin, are the main flavonoids and glucosinolate, respectively, while erucic acid and glucoerucin are the main fatty acid and glucosinolate, respectively. Medicinally, the plant has antibacterial, antidiabetic, antihypertensive, antiplatelet, and antioxidant activity and stimulates hair growth and other effects. Trails on topical pharmaceutical preparations involve the use of E. sativa which had been done. These preparations include creams and waxs which are intended to be used for potentiating hair growth and skin fungal and bacterial infection.

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“…Food Sci.50, No.1 (2022) MAHMOUD A. ROZAN AND ESMAIL. G. BORIY digestion, to improve kidney functions, astimulant in the treatment of stomach disorders, antiulcer, the treatment of nasal polyps and tumors, cure eye infection, as an aphrodisiac, and to stimulating the growth of testes and enhance the proliferation, maturation, and differentiation of spermatozoa (Barillari et al, 2005, Alqasoumi et al, 2009Barlas et al, 2013;Abd El-Aziz et al, 2016;Rizwana et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, phytochemical Profile, antioxidant activity of Eruca sativa seeds, and utilization of defatted seeds in the production of functional biscuits

Rozan

Boriy

2022

Egypt. J. Food Sci.

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E RUCA (Eruca sativa) seeds are valued as rich sources of macronutrients and phytochemicals, but their high erucic acid content may preclude their use in food applications, due to the health risks erucic acid. Therefore, this research aims to characterize the defatted Eruca seeds in terms of their chemical composition, phytochemical profile, antioxidant activity, functional properties, and the possibility of exploiting them in the production of functional biscuits with high phytochemical content and minimal erucic acid content. The results showed that defatted Eruca seeds flour (DESF) was extraordinarily rich in protein, carbohydrate, fiber, and ash contents with 38.78, 38.4, 9.13 and 5.33% (FW), respectively. The amino acids in Eruca protein were higher than those in the standard pattern except for threonine, methionine and tryptophan. Erucic acid content in Eruca oil was 39.16 g/100 fat and inDESF was 0.638 g/100 (FW). Whole Eruca seeds flour (WESF) extract showed greater antioxidant activity by about 1.24 and 1.53 times compared to DESF according to DPPH free radicalscavenging assay and FRAP assay, respectively. The most striking of phenolic compounds in both WESF and DESF is sinapic acid, which exceeds the amount of all other compounds that have been discovered. All studied functional properties were higher in DESF than in WESF. Finally, the results of the sensory evaluation indicate the possibility of replacing the DESF with up to 4% of wheat flour, with the improvement of most of the sensory acceptability parameters of the resulting biscuit, and the other sensory parameters not being negatively affected.

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Protective effect of Eruca sativa seed oil against oral nicotine induced testicular damage in rats

Cited by 17 publications

References 32 publications

Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse –a pilot study

Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse –a pilot study

Eruca Sativa Linn.: Pharmacognostical and Pharmacological Properties and Pharmaceutical Preparations

Chemical composition, phytochemical Profile, antioxidant activity of Eruca sativa seeds, and utilization of defatted seeds in the production of functional biscuits

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