Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A

Singh, Lovedeep; Kaur, Anudeep; Garg, Saweta; Singh, Amrit Pal

doi:10.1007/s11064-020-03095-y

Cited by 28 publications

(22 citation statements)

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“…A broad range of inflammatory or oxidative conditions have been shown to be impacted by esculetin. These include lung injury and fibrosis ( 356 , 357 , 520 ); fibromyalgia ( 521 ); neuronal oxidative stress ( 522 ); psoriasis ( 523 ); arthritis ( 358 ); nociception ( 359 ); colitis ( 360 ); allergy, immunity, and asthma ( 282 , 354 , 380 – 383 ); and sepsis ( 361 ). The effects of esculetin on numerous cancer cell types have been extensively studied ( 94 , 321 – 342 , 519 , 524 , 525 ) and are the basis for efforts to develop novel therapeutics ( 98 , 341 ).…”

Section: Effects Of Bioactive Compounds Found In a Scopariamentioning

confidence: 99%

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the foundation for standard anti-malarial therapies. Plants of the genus Artemisia are among the most common herbal remedies across Asia and Central Europe. The species Artemisia scoparia (SCOPA) is widely used in traditional folk medicine for various liver diseases and inflammatory conditions, as well as for infections, fever, pain, cancer, and diabetes. Modern in vivo and in vitro studies have now investigated SCOPA’s effects on these pathologies and its ability to mitigate hepatotoxicity, oxidative stress, obesity, diabetes, and other disease states. This review focuses on the effects of SCOPA that are particularly relevant to metabolic health. Indeed, in recent years, an ethanolic extract of SCOPA has been shown to enhance differentiation of cultured adipocytes and to share some properties of thiazolidinediones (TZDs), a class of insulin-sensitizing agonists of the adipogenic transcription factor PPARγ. In a mouse model of diet-induced obesity, SCOPA diet supplementation lowered fasting insulin and glucose levels, while inducing metabolically favorable changes in adipose tissue and liver. These observations are consistent with many lines of evidence from various tissues and cell types known to contribute to metabolic homeostasis, including immune cells, hepatocytes, and pancreatic beta-cells. Compounds belonging to several classes of phytochemicals have been implicated in these effects, and we provide an overview of these bioactives. The ongoing global epidemics of obesity and metabolic disease clearly require novel therapeutic approaches. While the mechanisms involved in SCOPA’s effects on metabolic, anti-inflammatory, and oxidative stress pathways are not fully characterized, current data support further investigation of this plant and its bioactives as potential therapeutic agents in obesity-related metabolic dysfunction and many other conditions.

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Section: Effects Of Bioactive Compounds Found In a Scopariamentioning

confidence: 99%

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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“…In rats with colitis, it was suggested by Witaicenis et al that esculetin with a dosage of 5 mg/kg not only increases the defense against ROS but also inhibits the secretion of proinflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-lβ, IL-2, and interferon (IFN)-γ, leading to the lower activation and less migration of inflammatory cells (Witaicenis et al, 2013). In mice with fibromyalgia induced by reserpine, esculetin (10 mg/kg) was demonstrated to relieve behavioral and biochemical deficits through the inhibition of the release of proinflammatory cytokines (TNF-α and IL-lβ) as well as the monoamine oxidase-A (MAO-A)mediated depletion of serotonin (Singh et al, 2020). The protective effects of esculetin against atopic dermatitis induced by exposing the ears of female BALB/c mice to dust mites were investigated by Jeong et al The results showed that esculetin in a concentration-dependent manner at doses between 2 and 50 mg/kg decreased the levels of immunoglobulin (Ig)E, IgG2a, and histamine in serum, reduced inflammatory cell infiltration in skin tissue, and inhibited the production of Th1, Th2, and Th17-related cytokines, including TNF-α, IFN-γ, IL-4, IL-13, IL-31, and IL-17.…”

Section: Antiinflammatory Activitymentioning

confidence: 99%

“…acaulis Pamp. (Compositae), Viola yedoensis Makino (Violaceae), among others (Ali et al, 2016;Li, Li, Li, & Ye, 2015;Masamoto et al, 2003;Rasmussen, Klausen, & Ekstrand, 2014;Singh, Kaur, Garg, Singh, & Bhatti, 2020).…”

Section: Introductionmentioning

confidence: 99%

Esculetin: A review of its pharmacology and pharmacokinetics

Zhang

Xie

2021

Phytotherapy Research

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Esculetin is a natural dihydroxy coumarin; it is mainly extracted from twig skin and the trunk bark of the Chinese herbal medicine Fraxinus rhynchophylla Hance. Emerging evidence suggests that esculetin has a wide range of pharmacological activities.Based on its fundamental properties, including antioxidant, antiinflammatory, antiapoptotic, anticancer, antidiabetic, neuroprotective, and cardiovascular protective activities, as well as antibacterial activity, among others, esculetin is expected to be a therapeutic drug for specific disease indications, such as cancer, diabetes, atherosclerosis, Alzheimer's disease (AD), Parkinson's disease (PD), nonalcoholic fatty liver disease (NAFLD), and other diseases. The oral bioavailability of esculetin was shown by studies to be low. The extensive glucuronidation was described to be the main metabolic pathway of esculetin and C-7 phenolic hydroxyl to be its major metabolic site.With the development of scientific research technology, the pharmacological effects of esculetin are identified and its potential for the treatment of diseases is demonstrated. The underlining mechanisms of action and biological activities as well as the pharmacokinetic data of the analyzed compound reported so far are highlighted in this review with the aim of becoming a proven, and applicable insight and reference for further studies on the utilization of esculetin.

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“…12 Therefore, studying the pattern of cytokines and the pathways that lead to the production of inflammatory cytokines in patients with depression can help determine the pathogenesis of the disease. 13 Receptorlike molecules, inflammatory inducers, NLR molecules, and signaling molecules are among the most important molecules that initiate inflammatory responses that increase cytokine expression. 14…”

Section: Introductionmentioning

confidence: 99%

A Review of the Role of Interleukin-2 in the Pathophysiology of Major Depressive Disorder in Hospitalized Patients

et al. 2021

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Background: Hospitalization due to any reason or medical condition is associated with fear, anxiety, and depression. Psychological and physiological factors have a significant impact on hospitalization outcomes. Objectives: Given the functional importance of inflammatory cytokines and studies in previous studies on the relationship between inflammatory cytokines and major depressive disorder, we will focus more on studies on the role of interleukin 2 (IL-2) in the pathophysiology of major depressive disorder in hospitalized patients. Methods: We used PubMed, Scopus, and Elsevier databases to search for articles from 1999 to 2021, emphasizing the studies of the last five years. Results: In general, there was no consistent pattern in the observed relationships between cytokine concentrations or changes and clinical signs of significant depression. IL-2 and IL, two receptors in the body, play an essential role in the treatment and the pathophysiology of depression and major depression. Conclusion: Finally, it can be concluded that hospitalization generally exposes the patient to inflammation. Studies show an increased risk of inflammation following hospitalization of patients, and many studies confirm the association of major depression with inflammatory cytokines and, more concentrated, IL-2.

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Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A

Cited by 28 publications

References 50 publications

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

Esculetin: A review of its pharmacology and pharmacokinetics

A Review of the Role of Interleukin-2 in the Pathophysiology of Major Depressive Disorder in Hospitalized Patients

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