Protective effect of estradiol on hepatocytic oxidative damage

Liu, Yan; Shimizu, Ichiro; Omoya, Toshihiro; Ito, Susumu; Gu, Xiaosong; Zuo, Jidong

doi:10.3748/wjg.v8.i2.363

Cited by 31 publications

(25 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concurrently, melatonin administration decreases lipid peroxidation and increases the levels of antioxidants [17]. MDA is a secondary product of oxidative stress formed during lipid peroxidation and is significantly increased by ischemia-reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary: Histopathologic and Immunohistochemical Study

Balsak¹,

Toğrul²,

Seçkin³

et al. 2015

OJOG

View full text Add to dashboard Cite

Aim: To investigate the effect of melatonin on ischemia-reperfusion (I/R) injury in rat ovary. Material and Method: A total of 24 Wistar rats were divided into four groups. The rats were first numbered randomly and then randomly divided into four equal groups: sham, torsion, detorsion and melatonin groups. In group I (n = 6) sham, as well as in group II ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. In group IV, melatonin was dissolved in 1% ethanol just before use. Melatonin was injected 1 hour before torsion to the torsion plus melatonin group. Right ovaries were surgically removed in all groups. Result: Malondialdehyde (MDA) levels were measured. We suggested that administration of melatonin would be in treating ovaries from torsion/detorsion induced damage in humans. The histopathological changes such as vascular con-* Corresponding author. D. Balsak et al. 640gestion, edema, hemorrhage, and follicular degeneration were found to be decreased in the melatonin + ischemia-reperfusion group. Ischemia-reperfusion group: PECAM-I expression is positive in vessel of the stromal area. The follicles and interfolicular area infiltrated with CD68 positive cells were increased in a time of ischemia-reperfusion exposure dependent manner. Conclusions: Melatonin after ischemia-reperfusion CD31 and CD68 expressions is weak, due to the reduction of the inflammatory effects and hemorrhage is thought that melatonin is effective.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary: Histopathologic and Immunohistochemical Study

Balsak¹,

Toğrul²,

Seçkin³

et al. 2015

OJOG

View full text Add to dashboard Cite

show abstract

“…High-intensity acute exercise causes more oxidative damage than lowintensity exercise (Lovlin et al, 1987), an effect that is especially true when an individual is not accustomed to either the intensity or the duration of the exercise (Viña et al, 2000). The amount of oxidative damage caused by exercise can differ between various tissues and organs (Liu et al, 2002). Exhaustive exercise, such as swimming, affects the level of MDA in the livers of both trained and untrained rats.…”

Section: Discussionmentioning

confidence: 99%

“…This report concluded that the observed gender difference in lipid peroxidation resulted from the suppression of free radical production in females by estradiol. Another study carried out in male rats reported that estradiol protects hepatocytes from oxidative damage due to its antioxidant effects (Liu et al, 2002). Joo et al (2004) reported that the free radicals produced during exercise at times when estradiol levels are high in women can be removed more easily than free radicals produced when estradiol levels are low.…”

Section: Discussionmentioning

confidence: 99%

The effects of gender and exercise on malondialdehyde, nitric oxide and total glutathione levels in rat liver

Pepe¹

2011

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

This study examined the effects of gender, acute exhaustive exercise and endurance training on the levels of malondialdehyde (MDA), nitric oxide (NOx) and total glutathione (GSH) in rat liver. The study was carried out with 12-week-old male and female Wistar rats. Rats were randomly divided into four subgroups: untrained-control, trained-control, untrained-exhausted, and trained-exhausted. Endurance training consisted of swimming 1 h each day, 5 days a week, for 8 weeks. Rats in exhausted exercise group were forced to swim until exhaustion. Levels of MDA and GSH in the liver were affected by both gender and acute exhaustive exercise. There were no significant interactions between gender, acute exhaustive exercise and endurance training on MDA, NOx or GSH levels in rat liver. In contrast to MDA and GSH levels, the level of NOx was not affected by acute exhaustive exercise or gender. Acute exhaustive exercise increased lipid peroxidation in the liver, especially in females. As a result, we conclude that gender, exhaustive exercise and endurance training do not have an effect on liver MDA, NOx and GSH levels.

show abstract

“…Hepatic fibrosis is a common consequence of chornic liver injury from many causes [15][16][17][18][19] , and the sustained hepatic injury is a primary factor for hepatic fibrogenesis [20][21][22][23][24][25][26][27][28] . Preventing hepatocyte from injury is a matter of primary importance in blocking the fibrogenic pathway.…”

Section: Discussionmentioning

confidence: 99%

Effects of tetrandrine on calcium and potassium currents in isolated rat hepatocytes

Zhou

Wang²,

Cheng³

et al. 2003

WJG

View full text Add to dashboard Cite

AIM:To study the effects of tetrandrine (Tet) on calcium release-activated calcium current (I CRAC ), delayed rectifier potassium current (I K ), and inward rectifier potassium currents (I K1 ) in isolated rat hepatocytes. METHODS:Hepatocytes of rat were isolated by using perfusion method. Whole cell patch-clamp techniques were used in our experiment. RESULTS:The peak amplitude of I CRAC was -508±115 pA (n=15), its reversal potential of I CRAC was about 0 mV. At the potential of -100 mV, Tet inhibited the peak amplitude of I CRAC from -521±95 pA to -338±85 pA (P<0.01 vs control, n=5), with the inhibitory rate of 35 % at 10 µmol/L and from -504±87 pA to -247±82 pA (P<0.01 vs control, n=5), with the inhibitory rate of 49 % at 100 µmol/L, without affecting its reversal potential. The amplitude of I CRAC was dependent on extracellular Ca 2+ concentration. The peak amplitude of I CRAC was -205±105 pA (n=3) in tyrode's solution with Ca 2+ 1.8 mmol/L (P<0.01 vs the peak amplitude of I CRAC in external solution with Ca 2+ 10 mmol/L). Tet at the concentration of 10 and 100 µmol/L did not markedly change the peak amplitude of delayed rectifier potassium current and inward rectifier potassium current (P>0.05 vs control). CONCLUSION:Tet protects hepatocytes by inhibiting I CRAC , which is not related to I K and I K1 .Zhou HY, Wang F, Cheng L, Fu LY, Zhou J, Yao WX. Effects of tetrandrine on calcium and potassium currents in isolated rat hepatocytes. World J Gastroenterol 2003; 9(1): 134-136

show abstract

Protective effect of estradiol on hepatocytic oxidative damage

Abstract: Estradiol protects hepatocytes from oxidative damage by means of its antioxidant activity.

Cited by 31 publications

References 41 publications

Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary: Histopathologic and Immunohistochemical Study

Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary: Histopathologic and Immunohistochemical Study

The effects of gender and exercise on malondialdehyde, nitric oxide and total glutathione levels in rat liver

Effects of tetrandrine on calcium and potassium currents in isolated rat hepatocytes

Contact Info

Product

Resources

About