Protective effect of exogenous melatonin in rats and their offspring on the genotoxic response induced by the chronic consumption of alcohol during pregnancy

Coelho, Ilka Dayane Duarte de Sousa; Neto, Clóvis José Cavalcanti Lapa; Souza, Talita Giselly dos Santos; Silva, Meykson Alexandre da; Chagas, Cristiano Aparecido; Santos, Katharine Raquel Pereira dos; Teixeira, Valéria Wanderley; Teixeira, Álvaro Aguiar Coelho

doi:10.1016/j.mrgentox.2018.06.018

Cited by 18 publications

(8 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another study administered alcohol into pregnant rats by gavage with or without melatonin (10 or 15 mg/kg, i.p. injection during gestational period) . In this model, melatonin administration decreased levels of alcohol‐induced liver damage not only in mothers but also in newborn pups .…”

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 74%

“…injection during gestational period). 30 In this model, melatonin administration decreased levels of alcohol-induced liver damage not only in mothers but also in newborn pups. 30 Although further studies are required to develop novel treatments for ALD targeting circadian rhythms and clock gene expressions, melatonin administration has shown promising therapeutic effects in these previous studies.…”

Section: Alcoholic Liver Diseasementioning

confidence: 79%

See 1 more Smart Citation

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

View full text Add to dashboard Cite

Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhythms and expressions as well as melatonin production. Previous studies indicate the association between circadian rhythms with various liver diseases, and disruption of rhythms or clock gene expression may promote liver steatosis, inflammation, or cancer development. It is well known that melatonin has strong antioxidant effects. Alcohol drinking or excess fatty acid accumulation produces reactive oxygen species and oxidative stress in the liver leading to liver injuries. Melatonin administration protects these oxidative stress‐induced liver damage and improves liver conditions. Recent studies have demonstrated that melatonin administration is not limited to antioxidant effects and it has various other effects contributing to the management of liver conditions. Accumulating evidence suggests that restoring circadian rhythms or expressions as well as melatonin supplementation may be promising therapeutic strategies for liver diseases. This review summarizes recent findings for the functional roles and therapeutic potentials of circadian rhythms and melatonin in liver diseases.

show abstract

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 74%

Section: Alcoholic Liver Diseasementioning

confidence: 79%

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

View full text Add to dashboard Cite

show abstract

“…Their results showed that cocaine caused genotoxicity in mussels. De Sousa Coelho et al (2018) studied the genotoxic effects of alcohol on embryonic and fetal development in rats and their offspring. Their results demonstrated that alcohol cause DNA damage in blood and liver of rats, offspring and neonates brain.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to Tramadol

Ali

Rafiq

Mubarik

et al. 2020

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Tramadol is an analgesic and psychoactive drug that acts primarily upon the central nervous system where it alters brain function, resulting in temporary changes in perception, mood, consciousness and behavior. The aim of present study was to analyze the genotoxicity and repair capability of DNA after Tramadol exposure in albino mice (Mus musculus). For this purpose, forty mice were divided equally into four groups as; a control group (without drug) and three treatment groups that were treated with three doses of Tramadol as minimum dose group, Intermediate dose group and maximum dose group, corresponding to 25 mg/kg, 50 mg/kg and 75 mg/kg of body weight respectively. The dose was given orally for 15 days. After 15 days peripheral blood was drawn from half mice of each group and subjected to comet assay. While the remaining half mice were given a recovery period of 15 days and same procedure was used for blood collection and comet assay. Significant difference in various comet parameters was observed among control and exposed groups. Maximum damage was observed at highest concentration 75 mg/kg of Tramadol and minimum damage was observed at dose 25 mg/kg of Tramadol, while results of repaired mice group showed that repair capability of Tramadol was minor and recovery of Tramadol required a lot of time. It can be concluded that Tramadol cause genotoxicity that is dose dependent and has low repair capability.

show abstract

“…With specific receptors in cell membranes (MT1 and MT2), melatonin has several functions as modulating the circadian cycle of antioxidant enzymes, bone metabolism, growth of ovarian follicles, ovulation, luteinizing hormone, fertilization and implantation ( Tamura et al ., 2009 ; 2014; Sharma et al ., 2015 ). This hormone can also exert antioxidant functions, due to its small molecular size and its lipolipid properties, being able to cross all cell membranes and reach intracellular compartments, as well as the nucleus and mitochondria, organelles with high concentrations ( León et al ., 2005 ; Waseem et al ., 2017 ), preventing damage to DNA ( Sousa Coelho et al ., 2018 ). The reduction in the occurrence and growth of tumors causes melatonin to be the most important natural oncostatic hormone in the human body ( Reiter, 2004 ; Cabrera et al ., 2010 ).…”

Section: Literature Reviewmentioning

confidence: 99%

Melatonin on hypothyroidism and gonadal development in rats: a review

Albuquerque

Silva

Souza

et al. 2020

JBRA Assisted Reproduction

Self Cite

View full text Add to dashboard Cite

We evaluated the evidence in research on the effects of melatonin on hypothyroidism and gonadal development. According to the World Health Organization, thyroid disorders due to iodine deficiency affect about 740 million people worldwide. Hypothyroidism is a thyroid dysfunction characterized by hypometabolism of the gland, with reduced or physiologically normal T3 and T4 serum levels, and high TSH level. This disorder occurs mainly in adult women in the reproductive phase, with a prevalence of 2% among the world's female population, with profound repercussions on gestation and fetal formation. During the gestational period, the thyroid is initially stimulated by high concentrations of human chorionic gonadotrophin; thus, maintaining maternal euthyroidism during pregnancy and lactation is fundamental for fetal growth and development. Besides, the hormones produced by this gland are involved in the formation of various organs, such as the skin, brain and gonads. Hypothyroidism is associated with several menstrual abnormalities, anovulation and hyperprolactinemia, resulting in a high rate of abortions, premature births, placental rupture, and weight-related neonatal deficits. In addition, there are studies showing that hypothyroidism can affect ovarian morphology (number of ovarian follicles) and testicular morphology (changes in the testicular-lumen epithelium). Melatonin is a hormone known to modulate the estrous cycle and pregnancy, and studies show that the exogenous application of melatonin increased T4 levels in female rats and controlled the decrease in T3 serum levels, reverting the sigs of hypothyroidism.

show abstract

Protective effect of exogenous melatonin in rats and their offspring on the genotoxic response induced by the chronic consumption of alcohol during pregnancy

Cited by 18 publications

References 63 publications

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Genotoxicity and repair capability of Mus musculus DNA following the oral exposure to Tramadol

Melatonin on hypothyroidism and gonadal development in rats: a review

Contact Info

Product

Resources

About