Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague–Dawley rats

Lee, Bae-Jin; Senevirathne, Mahinda; Kim, Young‐Mog; Lee, Myung-Suk; Jeong, Min-Ho; Kang, Young Mi; Kim, Jung Il; Nam, Byung-Hyouk; Ahn, Chang‐Bum; Je, Jae‐Young

doi:10.1016/j.fct.2010.02.006

Cited by 35 publications

(31 citation statements)

References 29 publications

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“…In addition, CCL4 induced a significant increase in MDA level in liver tissue as compared to control Fig. 1, which in agreement with Lee et al (2010) and Cai et al (2015). The high level of MDA is a reflection of the occurrence of lipid peroxidation, leading to liver tissue damage and failure of antioxidant defense mechanisms (Termini, 2000).…”

Section: Resultssupporting

confidence: 81%

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

Foaud

Kamel

El-Monem

2018

JoBAZ

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Background: Carbon tetrachloride (CCL4) is used as a solvent for oils and fats, as a refrigerant, and as a dry-cleaning agent. Inhalation of its vapors can depress central nervous system activity and cause degeneration of the liver and kidneys. Aim: The aim of this study was to investigate whether N-acetyl cysteine (NAC) has a protective effect on the toxicity caused by carbon tetrachloride. Methods: Male rats were used in this experiment. Animals were divided into five groups, 5 animals each: G1 received olive oil, G2 was treated with CCL4 (1 ml/kg body wt) dissolved in olive oil (1:1), G3 received NAC (300 mg/kg body wt), G4 received CCL4 plus NAC, and G5 received NAC for 1 week then administrated to the same treatment of G4. All administrations were performed by gavage and maintained for 4 weeks. Results: The present study revealed that administration of CCL4 caused a significant increase in liver marker enzymes Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and alkaline phosphatase (ALP); also, malondialdehyde (MDA) content in the liver tissue was increased. However, serum total protein showed no change in all groups. Also, histopathological investigation of CCL4 on the liver, testis, and kidney showed different deleterious effects. Additionally, CCl4 induced a highly significant increase in the percentage of sperm shape abnormality and sperm DNA tail moment values. Alternatively, result revealed that the two routes of NAC administrations caused a significant decrease in liver marker enzymes as well as MDA contents; improvement in liver, kidney, and testes architecture; a significant decrease in the percentage of sperm head abnormalities; and decline in the DNA tail moment values. Conclusion: The present study pointed out the protective effect of NAC against the toxicity of CCL4.

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Section: Resultssupporting

confidence: 81%

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

Foaud

Kamel

El-Monem

2018

JoBAZ

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“…In addition, our previous results revealed that the use of FSTJ results in enhancement of alcohol metabolism-related enzyme activities including alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) [15]. It was also reported that treatment with FSTJ decreased the levels of serum biochemical parameters related to hepatotoxicity such as GGT, glutamic pyruvate transaminase (GPT) and malondialdehyde (MDA), and increased the levels of oxidant-related factors such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in liver tissues compared to an ethanol and CCl4-treated group [16]. Based on our previous results, we hypothesized that FSTJ could play an important role in the pathogenesis of alcohol-induced hepatic damage by moderating GGT and oxidant stress.…”

Section: Resultsmentioning

confidence: 96%

“…GGT has long been considered as an effective biochemical markers to understand early hepatic injury [5,16]. GGT catalyses the breakdown of extracellular GSH and produces the metabolites used for GSH synthesis inside the cells.…”

Section: Resultsmentioning

confidence: 99%

Protective effect of GABA-enriched fermented sea tangle against ethanol-induced cytotoxicity in HepG2 Cells

Kang¹,

Qian

Lee³

et al. 2011

Biotechnol Bioproc E

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This study was conducted to evaluate the protective effects of GABA (gamma-amino butyric acid)-enriched sea tangle juice (STJ) by Lactobacillus brevis BJ-20 fermentation against alcohol hepatotoxicity. The protective effects were determined by assessing glutathione (GSH) content levels and gamma-glutamyl transpeptidase (GGT) activity against ethanol-induced cytotoxicity in HepG2 cells. In ethanol-treated cells, GSH content decreased to 44.35% of control (ethanol-untreated cell) values; however, treatment with fermented sea tangle juice (FSTJ) at a concentration of 25 µg/mL increased GSH levels to 67.08%. These results suggest that FSTJ may prevent intracellular GSH depletion caused by ethanol consumption. Treatment with FSTJ against alcohol-injured HepG2 cells resulted in a dose-dependent decrease in GGT activity. The expression of cytochrome P450 2E1 (CYP2E1) enzyme, a major contributor to ethanol-induced oxidative stress, was also completely inhibited in FSTJ-treated cells at a concentration of 25 µg/mL. Thus, this study demonstrated that ethanolinduced cytotoxicity could be attenuated by inhibition of GSH depletion, GGT activity, and CYP2E1 expression.

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“…(46) Several reports have suggested that, decreased activities of SOD and CAT in various carcinogenic conditions that may be due to the increased compensation of these anti-oxidant enzymes to neutralize the oxidative stress. (47) The anti-oxidant enzymes SOD, CAT and GPx that are activated against cell injury and also limit the effects of oxidant molecules on tissues (48) and was measured in the lung tissue where these processes have fundamental importance. (49) Our study also demonstrates a decreased levels of these non-enzymatic and enzymatic anti-oxidants in the B(a)P-induced animals which shows the increased requirement of the cells to neutralize the developed oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective effect of all-trans retinoic acid (ATRA) on oxidative stress and lung metastasis induced by benzo(a)pyrene

Ramya

Siddikuzzaman

Manjamalai

et al. 2011

Immunopharmacology and Immunotoxicology

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Chemoprevention is regarded as one of the most promising and realistic approaches in the prevention of cancer. All-trans retinoic acid (ATRA) is an active metabolite of vitamin A under the family retinoids, derived by irreversible oxidation of retinol (vitamin A), the parent compound for all natural retinoids. The aim of the present study is to divulge the chemopreventive and chemoprotective nature of ATRA during benzo(a)pyrene (B(a)P) induced lung cancer development in BALB/c mice. Administration of B(a)P (50 mg/kg body weight) to mice resulted in increased lipid peroxides (LPO), lipid hydroperoxides (LOOH) and nitric oxide (NO) with concomitant decrease in the levels of tissue anti-oxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and vitamin C. ATRA supplementation (0.585 mg/kg body weight) attenuated all these alterations, which indicates the anti-cancer effect that was further confirmed by histopathological analysis. Overall, the above data show that the anti-cancer effect of ATRA is more pronounced when used as an chemopreventive agent against B(a)P-induced lung carcinogenesis.

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Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague–Dawley rats

Cited by 35 publications

References 29 publications

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

The protective effect of N-acetyl cysteine against carbon tetrachloride toxicity in rats

Protective effect of GABA-enriched fermented sea tangle against ethanol-induced cytotoxicity in HepG2 Cells

Chemoprotective effect of all-trans retinoic acid (ATRA) on oxidative stress and lung metastasis induced by benzo(a)pyrene

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