Protective effect of germanium citrate in endotoxin-induced ovarian dysfunction in mice.

Kondratska, O.A.; Grushka, Nataliya; Kaplunenko, V. G.; Pavlovych, Svitlana; Срібна, В. О.; Yanchii, R. I.

doi:10.26641/2307-0404.2018.1(part1).127240

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Разом з тим, крім проаналізованих у попередніх пунктах статті, на сьогодні важливу роль у забезпеченні здоров'я і продуктивності тварин відіграють інші нові напрями одержання та застосування біологічно активних речовин, зокрема нанотехнології та наноматеріали [1,7,22,29,30,31,91]. Розроблено і досліджено наноматеріали, різні за технологічною формою, властивостями, походженням, застосуванням, які ефективно використовують у тваринництві та ветеринарній медицині [4,18,22,35,91,92].…”

Section: вплив нанотехнологічних сполук германію на організм тваринunclassified

Germanium compounds and their role in animal body

Fedoruk¹,

Kovalchuk²,

Mezentseva³

et al. 2022

Bìol. Tvarin

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Last years literature data and separate research results analysis was carried out concerning biological influence of Germanium compounds at laboratory and productive animals. The article states a comparative effect of mineral and organic Germanium compounds in chemical and biotechnological synthesis, as well as nanotechnological germanium citrate influence on the functioning of the immune, hematological, antioxidant, detoxification, reproductive and nervous systems of animals. The article displays a difference in influence of Germanium compounds on animal body depending on its form, dose and exposure. Benefits of using organic Germanium compounds in chemical, biotechnological and nanotechnological synthesis are highlighted based on a comparative analysis of the own research results, as well as other authors. Functioning analysis of a separate body organs, body systems as well as animal body in total was conducted after animals been exposed to short-term and long-lasting action of various Germanium compounds. Studies results for various Germanium compounds toxicity, their impact on animal productivity and product quality are stated based on the available literature. Comparison of influence effect for some drugs, biologically active additives and products containing Germanium compounds on the animal body was documented. Conclusions are made about the advantages of biological action of organic Germanium compounds, made by biotechnological synthesis using yeast Saccharomyces cerevisiae, and Germanium citrate, obtained on the basis of nanotechnology, regarding the prospects of its use in animal husbandry and veterinary medicine.

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Section: вплив нанотехнологічних сполук германію на організм тваринunclassified

Germanium compounds and their role in animal body

Fedoruk¹,

Kovalchuk²,

Mezentseva³

et al. 2022

Bìol. Tvarin

View full text Add to dashboard Cite

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The quality of ram spermatozoa after thawing with the addition of Mn2+, Zn2+ and Cu2+ nanocitrate to cryopreservation diluent

Sharan¹,

Stefanyk²,

Murawski³

2023

Bìol. Tvarin

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The aim of the study was to find out the effect of adding nanocitrate of Mn, Zn and Cu to the diluent for ram spermatozoa cryopreservation on its quality and ability for fertilizing. The experiment was carried out on six clinically healthy breeder 2–4-year-old rams of the Texel breed. The received ejaculates of the rams were evaluated for the volume, sperm concentration and motility and then divided into control and experimental groups. Control sperm samples were diluted with lactose-yolk-tris-citrate-glycerin medium (LYTCGM). Nanocitrates of microelements were added to the medium in experimental samples of ram sperm in the following doses: Zn2+ and Mn2+ — 2.5, 5.0 and 7.5 μg/l, Cu2+ — 1.25, 2.5 and 3.75 μg/l. The diluted sperm was packaged in straws, equilibrated for 2.5 h and frozen. After thawing of sperm we determined motility, survival of sperm, activity of succinate dehydrogenase (SDH) and cytochrome oxidase (CO), activity of antioxidant protection enzymes superoxide dismutase (SOD), glutathione peroxidase (HPO) and catalase (CAT). A dose- dependent effect of Mn, Zn, and Cu nanocitrates upon their addition to LYTCGM was established. Addition of nanocitrates of Mn, Zn to LYTCGM at a dose of 5.0 μg/l increased sperm motility by 22.2% (P<0.05) and 26.0% (P<0.01), and sperm survival, respectively, by 12.6% on (P<0.01) and 5.9% (P<0.05) compared to the control. Nanocitrates of Mn, Zn at a dose of 5.0 μg/l as part of LYTCGM caused a probable increase in SDH (P<0.001) and CO (P<0.05–0.01), which indicates a high fertilizing ability of ram spermatozoa. Similarly, when Mn, Zn nanocitrates were added to LYTCGM at a dose of 5.0 μg/l, SOD activity decreased by 29.6% (P<0.01) and 38.8% (P<0.01) and HPO activity increased by 43.5% (P<0.01) and 39.1% (P<0.01), and CAT — by 40.0% (P<0.05) and 37.5% (P<0.05), respectively. At the same time, the addition of Cu nanocitrate to LYTCGM with an increase in the dose significantly reduces the activity, survival and fertilizing capacity of thawed ram spermatozoa, and also worsens their antioxidant protection.

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Protective effect of germanium citrate in endotoxin-induced ovarian dysfunction in mice.

Cited by 2 publications

References 8 publications

Germanium compounds and their role in animal body

Germanium compounds and their role in animal body

The quality of ram spermatozoa after thawing with the addition of Mn2+, Zn2+ and Cu2+ nanocitrate to cryopreservation diluent

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