Protective effect of glutamine in critical patients with acute liver injury

Ni, Haibin; Zheng, Zeqi; Qin, Haidong

doi:10.5847/wjem.j.1920-8642.2011.03.010

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…[19,21,22,25] However, inappropriate antimicrobial therapy is just one of the factors independently associated with the mortality of patients with Acinetobacter baumannii infections. [37]…”

Section: Resultsmentioning

confidence: 99%

“…Ni et al[ 19 ] found that Acinetobacter baumannii preferably colonized or infected the respiratory tract, and such infections tend to occur in debilitated patients especially in the ICU. In comparison, Acinetobacter genomospecies 3 was more frequently involved in skin and soft tissue infections, such as surgical wound infection, and usually occurred in conventional wards, not in ICUs.…”

Section: Resultsmentioning

confidence: 99%

“…As Acinetobacter baumannii display resistance to more classes of antimicrobial agents than Acinetobacter genospecies 3 and 13TU, patients with Acinetobacter baumannii infections tend to be less likely to receive appropriate empirical therapy. [ 19 , 21 , 22 , 25 ] However, inappropriate antimicrobial therapy is just one of the factors independently associated with the mortality of patients with Acinetobacter baumannii infections. [ 37 ]…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

TheAcinetobacter baumanniigroup:a systemic review

Zhang

Qiao

2013

World Journal of Emergency Medicine

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BACKGROUND:The Acinetobacter baumannii group, including Acinetobacter baumannii, Acinetobacter genomospecies 3 and 13TU, is phenotypically indistinguishable and uniformly identified as Acinetobacter baumannii by laboratories of clinical microbiology. This review aimed to demonstrate the differences among them.METHODS:Literatures associated with the Acinetobacter baumannii group were identified and selected from PubMed databases and relevant journals.RESULTS:Acinetobacter genospecies 3 and 13TU possess a certain proportion in clinical isolates. There were considerable differences in epidemiologic features, clinical manifestations, antimicrobial resistances and therapeutic options among the Acinetobacter baumannii group. Compared with Acinetobacter genomospecies 3 and 13TU, Acinetobacter baumannii with a higher resistance to antimicrobial agents are easier to be treated inappropriately, and present a worse outcome in patients.CONCLUSION:The Acinetobacter baumannii group comprises three distinct clinical entities, and their clinical value are not equal.

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“…[19,21,22,25] However, inappropriate antimicrobial therapy is just one of the factors independently associated with the mortality of patients with Acinetobacter baumannii infections. [37]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

TheAcinetobacter baumanniigroup:a systemic review

Zhang

Qiao

2013

World Journal of Emergency Medicine

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“…Our patient was also using glutamine, which was actually a good thing, since it is known that glutamine decreases oxidative stress and inflammatory response in critically ill patients with acute liver injury. In that way, glutamine can improve prognosis of these patients [20]. It is possible that this contributed a speedy recovery of our patient regardless of the clinical presentation of severe liver damage.…”

Section: Discussionmentioning

confidence: 70%

Severe toxic acute liver injury

Mitrović¹,

Bojović

Simonović

et al. 2019

Srp Arh Celok Lek

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Introduction Toxic liver injury is becoming greater problem in today´s hepatology. Until today more than 900 drugs, toxins and herbs have been identified that can cause different liver injury. There was no significant research of this problem in Serbia so far. The aim of this study is to present the patient with severe form of acute hepatitis, whose etiology is exclusively toxic. Case outline A 23-year-old male, from Belgrade, previously healthy, got sick with signs and symptoms that correlated with acute hepatitis. Biochemical analyses pointed to severe form of acute hepatitis with impending hepatocellular failure. The diagnosis of toxic liver injury was set. It was caused by the use of number substances and supplements: ecstasy, whey protein, branched-chain amino acid (BCAA), creatine, high doses of vitamin D, glutamine, and multivitamin complex. He was treated with infusion, gastroprotective, and substitution therapy. During hospitalization, the patient's symptoms disappeared with gradual normalization of biochemical analyses of the liver. When the patient's condition was satisfying, blind percutaneous liver biopsy was performed, with the following pathohistological findings: lobular hepatitis, with no fibrosis, etiology correlates to toxic. After a month and a half since the disease had begun, the patient fully recovered. Conclusion Increased number of persons with toxic liver injury is being registered in developed countries worldwide. Similar trend can be noted in Serbia as well. By presenting young previously healthy man with the severe form of toxic acute hepatitis and impending liver failure, we are pointing out the significance of this problem. Multidisciplinary approach is needed to reach the most effective solutions.

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“…Contrary, Hai-bin Ni et al showed that in critical patients with acute liver injury MV time was shorter in the GLN group than in the control group but they could not claim that this result is strictly addicted to GLN supplement (23).…”

Section: Discussionmentioning

confidence: 91%

Immunological Effects of Glutamine Supplementation in Polytrauma Patients in Intensive Care Unit.

Cotoia

Cantatore

Beck

et al. 2021

Preprint

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Background In polytrauma intensive care unit (ICU) patients, glutamine (GLN) become a "conditionally essential" amino acid; its role has been extensively studied in numerous clinical trials but their results are inconclusive. We evaluated the IgA–mediated humoral immunity after GLN supplementation in polytrauma ICU patients. Results All consecutive patients with polytrauma who required mechanical ventilation and enteral nutrition (EN) provided within 24 hours since the admission in ICU at the University Hospital of Foggia from September 2016 to February 2017 were included. Thereafter, two groups were identified: patients treated by conventional EN (25 kcal/kg/die) and patients who have received conventional EN enriched with 50 mg/kg/ideal body weight of alanyl-GLN 20% intravenously. We analyzed plasmatic concentration of IgA, CD3+/CD4+ T Helper Lymphocytes, CD3+/CD8+ T suppressor Lymphocytes, CD3+/CD19+ B Lymphocytes, IL-4 and IL-2 at admission, at 4, 8 days. We identified 30 patients, with 15 subjects per group. IgA levels increased significantly in GLN vs control group at T0, T4 and T8.CD3+/CD4+ T helper lymphocytes and CD3+/CD8+ T suppressor lymphocytes levels significantly increased in GLN vs control group at T4 and T8. CD3+/CD19+ B lymphocytes levels increased significantly in GLN vs control group only at T8.IL-2 and IL-4 levels showed no significant differences when comparing GLN with control group. Conclusions Our study showed that there was an improvement in humoral and cell-mediated immunity with GLN supplementation in polytrauma ICU patients using recommended doses.

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Protective effect of glutamine in critical patients with acute liver injury

Cited by 8 publications

References 34 publications

TheAcinetobacter baumanniigroup:a systemic review

TheAcinetobacter baumanniigroup:a systemic review

Severe toxic acute liver injury

Immunological Effects of Glutamine Supplementation in Polytrauma Patients in Intensive Care Unit.

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