Protective effect of green tea against neuro-functional alterations in rats treated with MnO₂nanoparticles

Abstract

BACKGROUND: Inhalation of manganese-containing metal fumes at workplaces can cause central nervous damage including a Parkinson-like syndrome. Oxidative stress is likely to be involved in the pathomechanism, due to the presence of nano-sized metal oxide particles with high biological and chemical activity. Oxidative damage of the nervous system could be prevented or ameliorated by properly applied antioxidants, preferably natural ones such as green tea, a popular drink. The aim of this work was to see if orally applied green tea brew could diminish the functional neurotoxicity of manganese dioxide nanoparticles introduced into the airways of rats.

Green Tea, A Medicinal Food with Promising Neurological Benefits

“…An investigation showed that green tea as a material with many antioxidant molecules could lessen the changes in the spontaneous and evoked neuronal activity of cortex as well as peripheral neurons [ 85 ]. Hegazi et al .…”

Neurotoxic effects of subchronic intratracheal Mn nanoparticle exposure alone and in combination with other welding fume metals in rats

“…Parallel shift of the spontaneous cortical activity to higher frequencies was also observed. It was also found that green tea, a known powerful antioxidant (Guo et al 1996;Frei and Higdon 2003) could diminish these neuro-functional alterations in rats receiving intratracheal MnO2 NP exposure (Sárközi et al 2017).…”