Protective Effect of Hesperidin, a Citrus Flavanoglycone, Against γ-Radiation-Induced Tissue Damage in Sprague–Dawley Rats

Pradeep, Kannampalli; Ko, Kyong Cheol; Choi, Min‐Jae; Kang, Jung Ae; Chung, Young Jin; Park, Sang Hyun

doi:10.1089/jmf.2011.1737

Cited by 57 publications

(34 citation statements)

References 39 publications

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“…These in vitro results are consistent with Park's in vivo findings in which they evaluated the radioprotective activity of Hsd (50 mg/kg and 100 mg/kg orally administered for 7 days) against 1 Gy, 3 Gy and 5 Gy of γ radiation in Sprague-Dawley rats (Pradeep et al, 2008). Hsd also protected rat hearts and kidneys against the toxic damages of irradiation and improved changes in the corresponding parameters (Pradeep et al, 2012).…”

Section: Radiation Therapysupporting

confidence: 87%

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

et al. 2015

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Section: Radiation Therapysupporting

confidence: 87%

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

et al. 2015

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“…[27] Some studies showed HES supplement reduces oxidative and pathologic damages induced by IR in the liver, heart, and kidney. [252631]…”

Section: Discussionmentioning

confidence: 99%

“…Histopathologically, several investigations have demonstrated that HES has radioprotective effect against normal tissues exposed to RT. [25262728] This study was performed to evaluate the protective effect of HES against γ-irradiation-induced acute and chronic lung injury in male Sprague–Dawley rats.…”

Section: Introductionmentioning

confidence: 99%

Hesperidin as radioprotector against radiation-induced lung damage in rat: A histopathological study

et al. 2017

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Reactive oxygen species (ROS) are generated by ionizing radiation, and one of the organs commonly affected by ROS is the lung. Radiation-induced lung injury including pneumonia and lung fibrosis is a dose-limiting factor in radiotherapy (RT) of patients with thorax irradiation. Administration of antioxidants has been proved to protect against ROS. The present study was aimed to assess the protective effect of hesperidin (HES) against radiation-induced lung injury of male rats. Fifty rats were divided into three groups. G1: Received no HES and radiation (sham). G2: Underwent γ-irradiation to the thorax. G3: Received HES and underwent γ-irradiation. The rats were exposed to a single dose of 18 Gy using cobalt-60 unit and were administered HES (100 mg/kg) for 7 days before irradiation. Histopathological analysis was performed 24 h and 8 weeks after RT. Histopathological results in 24 h showed radiation-induced inflammation and presence of more inflammatory cells as compared to G1 (P < 0.05). Administration of HES significantly decreased such an effect when compared to G2 (P < 0.05). Histopathological evaluation in 8 weeks showed a significant increase in mast cells, inflammation, inflammatory cells, alveolar thickness, vascular thickness, pulmonary edema, and fibrosis in G2 when compared to G1 (P < 0.05). HES significantly decreased inflammatory response, fibrosis, and mast cells when compared to G2 (P < 0.05). Administration of HES resulted in decreased radiation pneumonitis and radiation fibrosis in the lung tissue. Thus, the present study showed HES to be an efficient radioprotector against radiation-induced damage in the lung of tissue rats.

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“…The realization of the action of natural antioxidants takes a certain period of time, so the effect is enhanced following the repeated their administration [41]. A peculiar feature of pharmaco-dynamics of the preparations comprising the "biological shield" is that the modifications in the radiation resistance of the organism under their impact do not happen immediately, but gradually over repeated administration, more often within 2 weeks, and can be maintained at the elevated level during the entire course of treatment and prevention [42,43]. When the preventive measures are well tolerated, they can be repeated without any loss of their effectiveness.…”

Section: Anti-radiation Effect Of Bioflavonoidsmentioning

confidence: 99%

Bioflavonoids as Important Component of Biological Protection from Ionizing Radiation

Vasin

2014

FNS

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New advances in the area of deciphering the mechanism for a possible modification of the biological effects of radiation exposure at the genetic level make it possible to distinguish the group of radiation protective agents having their own specific features in the implementation of their beneficial effects. The mechanism of the radioprotective action of bioflavonoids is worthy of a detailed analysis in view of their great biological importance. Radiobiological studies show that antioxidants can reduce the radiation damage to membranes and favor more adequate energy dependent adaptive and reparative processes after the exposure to radiation. Bioflavonoids are significant component of "biological protection" for a enhance of resistance of the body to environmental factors that are adverse for human health, including ionizing radiation, with reducing the risk of carcinogenic effects and decreasing the biological age. The best practical value of bioflavonoids, can be considered as the agents for prophylaxis against the development of oxidative stress. These are the reasons why the administration of natural antioxidants have a pathogenetic justification for exposures to chronic (months, years) low-rate-dose ionizing radiation. These agents were previously and are currently being developed for use during long-term, low-ratedose exposures to radiation, under conditions of long space missions. Acting as low-dose stressors through a hormetic mechanism and a "substrate" support of adaptive shifts radiomodulators results in an increase in the antioxidant defense of the body and the rearrangement of its functioning in the new environment with the modulation of gene expression of antioxidant response elements by activation of Nrd2/KeapI and Sirtuin/FoxO pathways and a decrease in the transcription factor NF-κB.

show abstract

Protective Effect of Hesperidin, a Citrus Flavanoglycone, Against γ-Radiation-Induced Tissue Damage in Sprague–Dawley Rats

Cited by 57 publications

References 39 publications

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

Hesperidin as radioprotector against radiation-induced lung damage in rat: A histopathological study

Bioflavonoids as Important Component of Biological Protection from Ionizing Radiation

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