Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

Iranshahi, Mehrdad; Rezaee, Ramin; Parhiz, Hamideh; Roohbakhsh, Ali; Soltani, Fatemeh

doi:10.1016/j.lfs.2015.07.014

Cited by 179 publications

(95 citation statements)

References 53 publications

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“…Neuroprotective effect of hesperidin on aluminum chloride induced Alzheimer's disease in Wistar rats has been shown earlier [53]. Protective activities of HSP against microbes and several toxicities induced by oxidants, chemicals, toxins, chemotherapy, and radiotherapy agents has been shown earlier in in vitro and in vivo studies [54].…”

Section: Discussionmentioning

confidence: 97%

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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Zinc oxide nanoparticles (ZnONPs) are widely used in food packaging and may enter the body directly if exposed. Hereby, in this study, the oral administration was selected as the route of exposure for rats to nanoparticles and the effect of hesperidin (HSP, 100 mg/kg bwt) was evaluated on ZnONP (600 mg/kg bwt)-induced neurotoxicity in rats. ZnONPs were characterized using transmission electron microscopy. Neurotoxicity was observed as seen by elevation in serum inflammatory markers including tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), and activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) content in rat brains. Pretreatment of rats with HSP in ZnONP-treated group elevated activities of antioxidant enzymes. HSP also caused decrease in TNF-α, IL-1β, IL-6, and CRP levels which was higher in the ZnONP-treated group. The results suggest that HSP augments antioxidant defense with anti-inflammatory response against ZnONP-induced neurotoxicity. The increased antioxidant enzymes enhance the antioxidant potential to reduce oxidative stress.

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Section: Discussionmentioning

confidence: 97%

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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“…The effects of flavonoids and gossypol on pathogens and insects are well documented (Nenaah, 2014;Iranshahi et al, 2015;Mechri et al, 2015). To test the biological activities of metabolites in extracts from the GhLac1 transgenic plants, methanolic extracts from each line were prepared.…”

Section: Altered Metabolites In Ghlac1 Rnai Lines Are Associated Withmentioning

confidence: 99%

Laccase GhLac1 Modulates Broad-Spectrum Biotic Stress Tolerance via Manipulating Phenylpropanoid Pathway and Jasmonic Acid Synthesis

et al. 2017

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Plants are constantly challenged by a multitude of pathogens and pests, which causes massive yield and quality losses annually. A promising approach to reduce such losses is to enhance the immune system of plants through genetic engineering. Previous work has shown that laccases (p-diphenol:dioxygen oxidoreductase, EC 1.10.3.2) function as lignin polymerization enzymes. Here we demonstrate that transgenic manipulation of the expression of the laccase gene GhLac1 in cotton (Gossypium hirsutum) can confer an enhanced defense response to both pathogens and pests. Overexpression of GhLac1 leads to increased lignification, associated with increased tolerance to the fungal pathogen Verticillium dahliae and to the insect pests cotton bollworm (Helicoverpa armigera) and cotton aphid (Aphis gosypii). Suppression of GhLac1 expression leads to a redirection of metabolic flux in the phenylpropanoid pathway, causing the accumulation of JA and secondary metabolites that confer resistance to V. dahliae and cotton bollworm; it also leads to increased susceptibility to cotton aphid. Plant laccases therefore provide a new molecular tool to engineer pest and pathogen resistance in crops.

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“…One class of compounds that has emerged with many promising antiviral candidates is the group of flavonoid molecules. Flavonoids are classified as polyphenol chemical compounds and are common in plants where they function in pigmentation (UV protection), in signaling processes, and as antimicrobials (7,8). The role of polyphenols in the diet has also been widely studied for antioxidant, anticarcinogenic, anti-inflammatory, and antihypercholesterolemic activities as well as cardio-and neuroprotective actions.…”

mentioning

confidence: 99%

Prophylactic Efficacy of Quercetin 3-β- O - d -Glucoside against Ebola Virus Infection

Qiu

Kroeker

et al. 2016

Antimicrob Agents Chemother

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Ebola outbreaks occur on a frequent basis, with the 2014-2015 outbreak in West Africa being the largest one ever recorded. This outbreak has resulted in over 11,000 deaths in four African countries and has received international attention and intervention. Although there are currently no approved therapies or vaccines, many promising candidates are undergoing clinical trials, and several have had success in promoting recovery from Ebola. However, these prophylactics and therapeutics have been designed and tested only against the same species of Ebola virus as the one causing the current outbreak. Future outbreaks involving other species would require reformulation and possibly redevelopment. Therefore, a broad-spectrum alternative is highly desirable. We have found that a flavonoid derivative called quercetin 3-␤-O-D-glucoside (Q3G) has the ability to protect mice from Ebola even when given as little as 30 min prior to infection. Furthermore, we have demonstrated that this compound targets the early steps of viral entry. Most promisingly, antiviral activity against two distinct species of Ebola virus was seen. This study serves as a proof of principle that Q3G has potential as a prophylactic against Ebola virus infection.

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Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin

Cited by 179 publications

References 53 publications

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Laccase GhLac1 Modulates Broad-Spectrum Biotic Stress Tolerance via Manipulating Phenylpropanoid Pathway and Jasmonic Acid Synthesis

Prophylactic Efficacy of Quercetin 3-β- O - d -Glucoside against Ebola Virus Infection

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