Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia

Xiong, Zhihui; Wei, Jing; Lu, Mengqi; Jin, Meiyuan; Geng, Hongling

doi:10.1016/j.biopha.2018.06.032

Cited by 67 publications

(52 citation statements)

References 30 publications

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“…We assume that multiple dosing can improve the therapeutic effect and need to be further validated. Second, we found that the effect of exosome treatment on improving erection was related to the increase of VEGF content in tissues; it may because stem cells can promote tissue angiogenesis by secreting VEGF‐rich exosomes . However, due to the inclusions of exosome are very complex, there are also related researches that attribute its active ingredients to miRNAs.…”

Section: Discussionmentioning

confidence: 95%

Mesenchymal stem cell‐derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury

Liu

Zhao

Luo

et al. 2019

J Cellular Molecular Medi

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Erectile dysfunction (ED) is a common ageing male's disease, and vascular ED accounts for the largest proportion of all types of ED. One of the mechanisms of vascular ED in the clinic is arterial insufficiency, which mainly caused by atherosclerosis, trauma and surgical. Moreover, oxidative stress damage after tissue ischemia usually aggravated the progress of ED. As a new way of acellular therapy, mesenchymal stem cell‐derived exosomes (MSC‐Exos) have great potential in ED treatment. In the current study, we have explored the mechanism of MSC‐Exos therapy in a rat model of internal iliac artery injury‐induced ED. Compared with intracavernous (IC) injection of phosphate‐buffered saline after artery injury, of note, we observed that both mesenchymal stem cells (MSCs) and MSC‐Exos through IC injection could improve the erectile function to varying degrees. More specifically, IC injection MSC‐Exos could promote cavernous sinus endothelial formation, reduce the organization oxidative stress damage, and improve the nitric oxide synthase and smooth muscle content in the corpus cavernosum. With similar potency compared with the stem cell therapy and other unique advantages, IC injection of MSC‐ Exos could be an effective treatment to ameliorate erectile function in a rat model of arterial injury.

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Section: Discussionmentioning

confidence: 95%

Mesenchymal stem cell‐derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury

Liu

Zhao

Luo

et al. 2019

J Cellular Molecular Medi

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“…The investigators observed a protective effect of UC-MSC on trophoblast cellular functions, opening a new avenue for treating placenta-related disorders like preeclampsia (109). Interestingly, exosomes derived from UC-MSC improved the morphology and angiogenesis of the placenta in a dose-dependent manner in a rat model of preeclampsia (110). Taken together, UC-MSCs may be beneficial for preeclampsia therapy and further studies are warranted.…”

Section: Umbilical Cord Mesenchymal Stem Cells (Uc-mentioning

confidence: 94%

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Esfandyari

Chugh

Park

et al. 2020

Preprint

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Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency and to improve reproductive health for a significant number of women worldwide.

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“…Emerging evidence suggests that neurological disorders can be successfully treated by exosome-based therapy when the auto-regenerative capacity of the central nervous system (CNS) is limited [126][127][128]. BM-MSC-derived exosomes and human umbilical cord (hUC) MSC exosomes are also effectively used for cardiac tissue neovascularization following ischemic injury [129] and for endothelial function enhancement, respectively [130,131]. Similarly, liver function is ameliorated by MSC-derived exosomes through the epithelial-mesenchymal transition (EMT) of hepatocyte and collagen production and through serum aspartate aminotransferase restoration [132][133][134][135].…”

Section: Exosomes Derived From Mesenchymal Stem/stromal Cells Of Diffmentioning

confidence: 99%

Exosome: A New Player in Translational Nanomedicine

Aheget

Tristán‐Manzano

Mazini

et al. 2020

JCM

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Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications.

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Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia

Cited by 67 publications

References 30 publications

Mesenchymal stem cell‐derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury

Mesenchymal stem cell‐derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Exosome: A New Player in Translational Nanomedicine

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