Protective Effect of <i>Aster tataricus</i> L. Extract on the Dermal Cytotoxicity Induced by Sodium Bromate, Oxidant of Hair Dye

The protective effects of a Celastrus orbiculatus Thunb (CO) extract against manganese dioxide (MnO2)-induced cytotoxicity in cultured C6 glioma cells were examined. This study assessed the antioxidative effects, including the suppressive ability of lipid peroxidation (LP), the inhibitory ability of xanthine oxidase (XO), and the cell viability. MnO2 decreased the cell viability remarkably in a dose-dependent manner. The XTT50 value was determined to be 146.7 μM in these cultures. The cytotoxicity of MnO2 was calculated to be mid-toxic using Borenfreund and Puerner's toxic criteria. Kaempferol (KAE) increased the cell viability damaged by MnO2-induced cytotoxicity significantly. Regarding the protective effects of the CO extract on MnO2-induced cytotoxicity, the CO extract increased cell viability significantly compared to the MnO2-treated group. The CO extract also had inhibitory abilities against lipid peroxidation (LP) and xanthine oxidase (XO). From these findings, oxidative stress is involved in the cytotoxicity of MnO2. The CO extract effectively blocked the cytotoxicity induced by MnO2 via its antioxidative effects. Conclusively, natural resources, such as the CO extract, might be a useful agent for the diminution or improvement of the heavy metal cytotoxicity correlated with disease through oxidative stress, such as MnO2, a Parkinsonism inducer.

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Antioxidative Effects of Parnassia palustris L. Extract on Ferrous Sulfate-Induced Cellular Injury of Cultured C6 Glioma Cells

Seo

Yang

2022

Korean J Clin Lab Sci

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This study sought to evaluate the mechanism of cellular injury caused by ferrous sulfate (FeSO4) and the protective effects of Parnassia palustris L. (PP) extract against FeSO4-induced cytotoxicity of cultured C6 glioma cells. FeSO4 is known to cause neurotoxicity and induce Parkinson's disease. The antioxidative effects of PP, such as superoxide dismutase (SOD)-like and superoxide anion-radical (SAR)-scavenging activities, as well as effects on cell viability, were studied. FeSO4 significantly decreased cell viability in a dose-dependent manner and the XTT50 value, the concentration of FeSO4 which reduced the cell viability by half, was measured at 63.3 μM in these cultures. FeSO4 was estimated to be highly cytotoxic by the Borenfreund and Puerner toxicity criteria. Quercetin, an antioxidant, significantly improved cell viability, damaged by FeSO4-induced cytotoxicity. While evaluating the protective effects of the PP extract on FeSO4-induced cytotoxicity, it was observed that the extract significantly increased cell viability compared to the FeSO4-treated group. Also, the PP extract showed superoxide dismutase (SOD)-like and superoxide anion radical (SAR)-scavenging activities. Based on these findings, it can be concluded that FeSO4 induced oxidative stress-related cytotoxicity, and the PP extract effectively protected against this cytotoxicity via its antioxidative effects. In conclusion, natural antioxidant sources such as PP may be agents useful for preventing oxidative stress-related cytotoxicity induced by heavy metal compounds such as the FeSO4, a known Parkinsonism inducer.

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Protective Effect of Aster tataricus L. Extract on the Dermal Cytotoxicity Induced by Sodium Bromate, Oxidant of Hair Dye

Cited by 3 publications

References 25 publications

Aster tataricus L.f.: Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activities

Aster tataricus L.f.: Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activities

Protective Effect ofCelastrus orbiculatusThunb Extract on Cultured Neuroglial Cells Damaged by Manganese Dioxide, a Parkinsonism Inducer

Antioxidative Effects of Parnassia palustris L. Extract on Ferrous Sulfate-Induced Cellular Injury of Cultured C6 Glioma Cells

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