Protective effect of <i>Curcuma amada</i> acetone extract against high-fat and high-sugar diet-induced obesity and memory impairment

Rao, Lakshmi Sudeepthi Nissankara; Kilari, Eswar Kumar; Kola, Phani Kumar

doi:10.1080/1028415x.2019.1616436

Cited by 20 publications

(9 citation statements)

References 56 publications

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“…These effects have been attributed to the antioxidant properties and anticholinesterase activity of curcuminoids and terpenoids present in the tested extract. Furthermore, they increased serotonin and dopamine levels, exerting neuroprotection of hippocampal neurons [79].…”

Section: Pharmacological Strategies To Improve Nafld/nash-related Cogmentioning

confidence: 99%

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

2020

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Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis (NASH) are important causes of liver disease worldwide. Recently, a significant association between these hepatic diseases and different central nervous system (CNS) disorders has been observed in an increasing number of patients. NAFLD-related CNS dysfunctions include cognitive impairment, hippocampal-dependent memory impairment, and mood imbalances (in particular, depression and anxiety). This review aims at summarizing the main correlations observed between NAFLD development and these CNS dysfunctions, focusing on the studies investigating the mechanism(s) involved in this association. Growing evidences point at cerebrovascular alteration, neuroinflammation, and brain insulin resistance as NAFLD/NASH-related CNS manifestations. Since the pharmacological options available for the management of these conditions are still limited, further studies are needed to unravel the mechanism(s) of NAFLD/NASH and their central manifestations and identify effective pharmacological targets.

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Section: Pharmacological Strategies To Improve Nafld/nash-related Cogmentioning

confidence: 99%

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

2020

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“…HFHF diet has previously been implicated in the progression of insulin resistance, which in turn is positively correlated to neurodegeneration, as well as the increase in monoamine turnover, and generalized brain oxidative stress status . It was previously demonstrated that ingestion of high fat with added sugars such as sucrose and fructose is a major causative factor for cognitive impairment . Moreover, oxidative stress and neuroinflammation are considered to be crucial mediators of such mental disorders .…”

Section: Discussionmentioning

confidence: 99%

“…Adding to this cascade, neurotransmitters are important for learning and memory processes. A decrease in dopamine and serotonin contents has been proposed to cause memory impairment, , and enhancement of dopaminergic signaling has been implicated in the regulation of cognitive flexibility . Serotonergic transmission was proven to modulate decision making, working memory, and attention.…”

Section: Discussionmentioning

confidence: 99%

Biological and Pharmacological Characterization of Ascorbic Acid and Nicotinamide Chitosan Nanoparticles against Insulin-Resistance-Induced Cognitive Defects: A Comparative Study

et al. 2021

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High consumption of industrialized food with high fat content is generally associated with insulin resistance, which in turn causes memory impairment and cognitive decline. Nicotinamide and ascorbic acid are among the promising neuroprotective molecules; however, an appreciable therapeutic activity necessitates the administration of a large dose of either. Therefore, the study aimed to assess if loading them in chitosan nanoparticles in doses 5–10 times lower than the unencapsulated forms would achieve comparable therapeutic results. Animals were fed a high-fat-high-fructose (HFHF) diet for 75 days. The vitamins in their conventional form (100 mg/kg) and the nanoparticles under investigation (10 and 20 mg/kg) were given orally concomitantly with the diet in the last 15 days. The intake of HFHF diet for 75 days led to an insulin-resistant state, with memory impairment, which was verified behaviorally through the object recognition test. This was accompanied by significant reduction in brain insulin-like growth factor 1 (IGF-1), increased acetylcholine esterase activity, increase in the serotonin and dopamine turnover ratio, and increase in oxidative stress and 8-OHdG, indicating cellular DNA fragmentation. Cellular energy was also decreased, and immunohistochemical examination verified the high immunoreactivity in both the cortex and hippocampus of the brain. The administration of nanoparticulated nicotinamide or ascorbic acid with a 10 times lesser dose than the unencapsulated forms managed to reverse all aforementioned harmful effects, with an even lesser immunoreactivity score than the unencapsulated form. Therefore, it can be concluded that nicotinamide or ascorbic acid chitosan nanoparticles can be recommended as daily supplements for neuroprotection in patients suffering from insulin resistance after conduction of clinical investigations.

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“…Rats were fed a diet high in fat and sucrose composed of three ml Banaspati ghee and one ml coconut oil given in a dose of 10 ml/kg, and 25 % sucrose was added to their drinking water bottles. Normal Fat Diet was fed to control rats (NFD Diet), which consisted of 70% carbohydrate, 20% protein, and 10% fat ( Nissankara Rao et al, 2021 ). NFD diet is made up of crude protein (20%), crude oil (10%), Ash (10%), sand silica (0.15%), and crude fiber (4%) ( Solanki & Bhatt, 2010 ).…”

Section: Methodsmentioning

confidence: 99%

Cepharanthine action in preventing obesity and hyperlipidemia in rats on a high-fat high sucrose diet

Iqbal

Najam²,

Simjee³

et al. 2022

Saudi Pharmaceutical Journal

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Protective effect of Curcuma amada acetone extract against high-fat and high-sugar diet-induced obesity and memory impairment

Cited by 20 publications

References 56 publications

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH

Biological and Pharmacological Characterization of Ascorbic Acid and Nicotinamide Chitosan Nanoparticles against Insulin-Resistance-Induced Cognitive Defects: A Comparative Study

Cepharanthine action in preventing obesity and hyperlipidemia in rats on a high-fat high sucrose diet

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