Protective Effect of
            <i>Panax Ginseng</i>
            in Cisplatin-Induced Cachexia in Rats

Lobina, Carla; Carai, Mauro A M; Loi, Barbara; Gessa, Gian Luigi; Riva, Antonella; Cabri, Walter; Petrangolini, Giovanna; Morazzoni, Paolo; Colombo, Giancarlo

doi:10.2217/fon.13.276

Cited by 12 publications

(11 citation statements)

References 33 publications

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“…Donkey-hide gelatin was clearly confirmed to promote the recovery of bone marrow hemopoietic function in a myelosuppressed mouse model [23]. American ginseng was reported to exert the chemo-preventive effects by anti-inflammatory and antioxidant mechanisms [24] and Panax ginseng extract exerted a protective effect in a rat model of cachexia and suggest that Panax ginseng extract may be a therapeutic promising tool for supportive care in oncology [25]. Besides, the organic extract of Angelica can inhibit body weight decrease caused by DDP and reduce DDP toxicity due to decreasing release of LDH, AST, ALT, and AKP into blood and enhancing thymus protection [26].…”

Section: Discussionmentioning

confidence: 99%

Yi-qi-yang-yin-tian-sui-fang enhances cisplatin-induced tumor eradication and inhibits interleukin-7 reduction in non-small cell lung cancer

Yang

et al. 2019

Bioscience Reports

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Traditional Chinese Medicine (TCM) has been recognized to be conducive to enhancing the efficiency and reducing the side effects in the whole course of cancer treatment. The mechanisms of TCM/chemotherapy combination involved with interleukin-7 (IL-7) potentially enhance immune responses against tumor. In the present study, we emphasized on a herbal formulation Yi-qi-yang-yin-tian-sui-fang or TCM for short, and investigated its roles in chemotherapy in non-small cell lung cancer (NSCLC). The mice bared with tumor were treated with cisplatin (DDP) and simultaneously administrated with/without low, medium and high doses of TCMs (effective content: 0.5, 2.0 and 8.0 g/per mice) via oral gavage. The results indicated that combination of TCM further elevated the therapy efficiency of DDP in a dose-dependent manner. The growth of tumor cells was estimated by Ki-67 stain and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) assay. The addition of TCM to the DDP treatment could significantly decrease the expression of Ki-67 and promote the apoptosis of tumor cells. In addition, the serum IL-7 level was down-regulated by DDP but restored by the treatment of TCM. The expression of IL-7 and its receptor IL-7R in tumor tissues was also recovered by TCM. Furthermore, the side effect from bone marrow suppression (myelosuppression) induced by DDP were assessed. TCM could abrogate DDP-induced apoptosis of bone marrow and also remarkably induced the expressions of IL-7 and hematopoietic growth factors including G-CSF, GM-CSF, SCF, and SDF-1 in bone marrow. These data indicated that this TCM combined with DDP showed superior anti-tumor effects with reduced myelosuppression via up-regulating IL-7.

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Section: Discussionmentioning

confidence: 99%

Yi-qi-yang-yin-tian-sui-fang enhances cisplatin-induced tumor eradication and inhibits interleukin-7 reduction in non-small cell lung cancer

Yang

et al. 2019

Bioscience Reports

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“…Increasing evidence suggests that KRG is a potent regulator of hair growth [17] , [18] , [19] , [20] , [21] . Furthermore, KRG can protect against side effects of chemotherapy and radiotherapy [36] , [37] , [38] , [39] , [40] . Here, we used an in vitro human hair follicle organ culture model for CIA [22] to examine whether KRG can protect against premature catagen development in response to a key cyclophosphamide metabolite, 4-HC.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model

Keum

Hwang³

et al. 2016

Journal of Ginseng Research

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BackgroundChemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo.MethodsWe examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC).Results4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HC-induced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression.ConclusionOverall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.

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“…ginseng extract exerted a protective effect in a rat model of cachexia and suggests that it may be a therapeutic promising tool for supportive care in oncology (Lobina et al, 2014). ginseng extract exerted a protective effect in a rat model of cachexia and suggests that it may be a therapeutic promising tool for supportive care in oncology (Lobina et al, 2014).…”

Section: Anticancer and Immunomodulatory Effectsmentioning

confidence: 99%

Phytochemical and biological research of Panax medicinal resources

Hao¹

2015

Medicinal Plants

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Protective Effect of Panax Ginseng in Cisplatin-Induced Cachexia in Rats

Abstract: These data indicate that treatment with Panax ginseng extract exerted a protective effect in a rat model of cachexia and suggest that Panax ginseng extract may be a therapeutic promising tool for supportive care in oncology.

Cited by 12 publications

References 33 publications

Yi-qi-yang-yin-tian-sui-fang enhances cisplatin-induced tumor eradication and inhibits interleukin-7 reduction in non-small cell lung cancer

Yi-qi-yang-yin-tian-sui-fang enhances cisplatin-induced tumor eradication and inhibits interleukin-7 reduction in non-small cell lung cancer

Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model

Phytochemical and biological research of Panax medicinal resources

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