Protective effect of L-carnitine nanoparticles Vs carnitine on lead acetate-induced toxicity in male rats.

Mahdi, Hayder Talib; Ghadhban, Rashad Fadhil

doi:10.5455/jabet.2022.d138

Cited by 2 publications

(2 citation statements)

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“…Therefore, dietary supplements-in particular, the use of nanoparticle supplements with higher bioavailability-have emerged. In a study investigating the effects of LC and LC-NLCs with a different design, it was reported that the biological effects of LC-NLCs were higher than or equal to LC with a lower administrated dosage [36]. In another study, 5 h steady-state hypercarnitinemia (~tenfold elevation of plasma carnitine) induced by intravenous L-carnitine infusion did not affect skeletal muscle content [37].…”

Section: In Vivo Studymentioning

confidence: 97%

Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity

Uner,

Ergin,

Ansari

et al. 2023

Molecules

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Addressing obesity is a critical health concern of the century, necessitating urgent attention. L-carnitine (LC), an essential water-soluble compound, plays a pivotal role in lipid breakdown via β-oxidation and facilitates the transport of long-chain fatty acids across mitochondrial membranes. However, LC’s high hydrophilicity poses challenges to its diffusion through bilayers, resulting in limited bioavailability, a short half-life, and a lack of storage within the body, mandating frequent dosing. In our research, we developed LC-loaded nanoparticle lipid carriers (LC-NLCs) using economically viable and tissue-localized nanostructured lipid carriers (NLCs) to address these limitations. Employing the central composite design model, we optimized the formulation, employing the high-pressure homogenization (HPH) method and incorporating Poloxamer® 407 (surfactant), Compritol® 888 ATO (solid lipid), and oleic acid (liquid oil). A comprehensive assessment of nanoparticle physical attributes was performed, and an open-field test (OFT) was conducted on rats. We employed immunofluorescence assays targeting CRP and PPAR-γ, along with an in vivo rat study utilizing an isolated fat cell line to assess adipogenesis. The optimal formulation, with an average size of 76.4 ± 3.4 nm, was selected due to its significant efficacy in activating the PPAR-γ pathway. Our findings from the OFT revealed noteworthy impacts of LC-NLC formulations (0.1 mg/mL and 0.2 mg/mL) on adipocyte cells, surpassing regular L-carnitine formulations’ effects (0.1 mg/mL and 0.2 mg/mL) by 169.26% and 156.63%, respectively (p < 0.05).

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Section: In Vivo Studymentioning

confidence: 97%

Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity

Uner,

Ergin,

Ansari

et al. 2023

Molecules

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“…(10) On the other hand, interleukin-37 (IL-37), a cytokine of IL-1 family, is secreted by a broad range of cells and tissues. (11) IL-37 receptor signaling results in several intracellular switches being triggered, which in turn causes the downregulation of proinflammatory genes and the suppression of the production of inflammatory cytokines. (12) Inhibiting inflammatory mediators in malignancies, autoimmune illnesses, and infectious diseases enables IL-37 to possess a powerful immunosuppressive effect against innate and acquired immune responses.…”

Section: Introductionmentioning

confidence: 99%

Osteoprotegerin and Interleukin-37 are Correlated with Liver Diseases in Chronic Hepatitis B Virus (HBV)-infected Subjects

Alsalimi,

Al-Mashkor,

Al-Fartosy

2023

Indones Biomed J

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BACKGROUND: Various biological markers have been proposed to predict subclinical events in subjects with chronic hepatitis B virus (HBV). However, studies regarding chronic HBV infection are still limited. The current study aimed to investigate the relationship between osteoprotegerin (OPG) and interleukin-37 (IL-37) serum levels in chronic HBV subjects.METHODS: Sixty subjects with chronic HBV infection without previous treatment and 30 healthy subjects were included in this study. Blood samples were withdrawn and examined for biochemical parameters through the use of enzyme-linked immunosorbent assay (ELISA) assessments. Moreover, anthropometric estimations and medical histories were performed on all subjects through a standard self-administered questionnaire.RESULTS: A highly significant elevation (p<0.01) in serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and IL-37 and a significant increase (p<0.05) in serum level of OPG were observed in chronic HBV subjects compared with the controls. The data demonstrated that OPG had a positive correlation with IL-37 and that both OPG and IL-37 had significantly positive correlations with ALT and AST. Furthermore, the area under the receiver operating characteristics (ROC) curve (AUC) was computed for ALT, AST, OPG, and IL-37 (AUC = 0.831, 0.829, 0.608, and 0.618, respectively) which could be potentially greater predictive biomarkers in chronic HBV subjects.CONCLUSION: The positive correlation of OPG and IL-37 with ALT and AST and the high positive value of AUC for OPG and IL-37 shows that OPG and IL-37 could to be potential inflammatory biomarkers for the early onset of liver disease and hepatocellular carcinoma in chronic HBV-infected subjects.KEYWORDS: osteoprotegerin, interleukin-37, hepatitis B virus, inflammation, liver

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Protective effect of L-carnitine nanoparticles Vs carnitine on lead acetate-induced toxicity in male rats.

Cited by 2 publications

References 0 publications

Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity

Assessing the In Vitro and In Vivo Performance of L-Carnitine-Loaded Nanoparticles in Combating Obesity

Osteoprotegerin and Interleukin-37 are Correlated with Liver Diseases in Chronic Hepatitis B Virus (HBV)-infected Subjects

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