Protective Effect of Lactoferrin against Chromium Induced Adverse Renal Changes in Rats: Oxidative Stress Theory

Hassan, Mohammed H.; Zaghloul, Dorreia Abd-Alla Mohamed; Mahmoud, Marwa A.; Abdel-Moaty, Zamzam Nasrallah; Toghan, Rana

doi:10.3844/ajbbsp.2021.181.191

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Our results also revealed a significant and abnormal increase in total BUN and creatinine levels in mice intoxicated with POD (group III) over control groups I and group II. These results align with those of Hassan et al [23], who stated that a single-dose POD injection for 14 days induced acute kidney injury in rats, as evidenced by significant renal function test alterations. When compared with other groups, there was a statistically significant increase in levels of urea and creatinine in the POD-treated group, which may be attributed to a loss of functional integrity in the kidney and renal tubule distortion as a consequence of Cr administration [33].…”

Section: Discussionsupporting

confidence: 92%

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Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

Almilaibary

Elrefaei

2022

Heliyon

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Section: Discussionsupporting

confidence: 92%

“…Renal tubular toxicity, inflammation, glomerular injury, crystal nephropathy, and thrombotic microangiopathy are some of the mechanisms that cause nephrotoxicity [ 22 ]. The kidney is a target organ for systemically absorbed chromate, and nephrotoxicity, or total renal shutdown, may be the main cause of death in acute Cr exposure [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

Almilaibary

Elrefaei

2022

Heliyon

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“…In, proximal convoluted tubules, chromium compounds are selectively deposited where they produce acute tubular necrosis in large dosages after parenteral administration. [78] Figure 7 Motion-related protein 1 (DRP1) regulates mitochondrial fission, whereas mitofusin 1 (MFN1) and mitofusin 2 control mitochondrial fusion (MFN2). Peroxisome proliferation-activated receptor-g coactivator-1a (PGC-1a) controls DRP1 and MFN2 expression.…”

Section: Chromium Induced Nephrotoxicitymentioning

confidence: 99%

Screening models of nephrotoxicity and their molecular mechanism

Kour¹,

Singh²,

Jaiswal³

et al. 2023

World J. Bio. Pharm. Health Sci.

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Kidney is among the most vital organs in the anatomy of human body which filters 200 litres of fluid every 24 hours and has many more function which include regulating acid-base balance, maintaining electrolytes balance, eliminating waste and toxins products from the human body. Nephrotoxicity refers as the deterioration in the kidney function due to toxic effect of drugs and chemical and is characterized by alterations in glomerular hemodyanmics, renal tubular failure and thrombotic microangiopathy. Drug-induced nephrotoxicity is becoming more well identified as a principal reasons of kidney illness, such as acute kidney injury (AKI) and chronic kidney disease (CKD) (CKD). Nephrotoxicity covers a broad range, displaying damage to various nephron segments as a result of distinct pharmacological actions. There are various agents which exerts nephrotoxic effects through pathogenic mechanisms like non-steroidal agents (Indomerhacin, Paracetamol, Mefenamic acid), anticancer agents (Carmustine, Cisplatin, Methotrexate), antibiotics (Gentamicin, Tobramycin, Amikacin), antiviral (Acyclovir, Tenofovir, Cidofovir), antifungal (Amphotericin B, Vancomycin, Nystatin)and immunosuppresant drugs(Cyclosporine, Tacrolimus). Alteration in glomerular hemodynamics, tubular cell toxicity, inflammation, crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy are all possibilities for drug-induced nephrotoxicity. In this review, we have explained different experimental models for nephrotoxicity that might assist in developing novel drugs to cure nephrotoxicity.

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Ameliorative effect of aqueous avocado seed extract against chromium‐induced oxidative stress and cellular damage in rabbit kidney

Okail,

Anjum,

Emam

et al. 2024

Food Science & Nutrition

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The accumulation of chromium in renal tissues promotes the generation of reactive oxygen species (ROS), leading to oxidative stress, genomic and cellular harm, and ultimately necrotic and apoptotic cell death induced by free radicals. Hence, the utilization of antioxidant phytochemicals becomes crucial for cellular defense against oxidative damage. This study endeavors to explore the potential protective effects of an aqueous avocado seed extract (ASE) on rabbit kidneys exposed to chromium‐induced damage. Fifteen adult rabbits were distributed into three groups: Group 1 was kept as the control. The second and third groups received a daily dose of K2Cr2O7 (5 mg/kg) intraperitoneally for 2 weeks. While the third group was given an oral dose of ASE (400 mg/kg). In rabbits administered with Cr (VI), kidney homogenates showed a marked increase in Malondialdehyde (MDA) (69.3 ± 4.1 nmol/g) along with a decrease in glutathione (59 ± 5.8 nmol/mg) content and the activity superoxide dismutase (SOD) (0.5 ± 0.05 U/mg protein), glutathione peroxidase (GPx) (16.7 ± 1.1 μmol/mg protein), and catalase (CAT) (73.8 ± 3.9 U/g protein) compared to the levels in control group. Also, the gene expression data for the enzymes SOD, GPx, and CAT dropped dramatically in kidney tissue following Cr (VI) injection. Additionally, Bowman's capsule and glomerulus showed degenerative alterations in the kidney's histopathology and immunohistochemistry. ASE treatment when administered along with Cr (VI) enhanced the activity and gene expression of antioxidant enzymes and improved histopathological conditions. The findings of this study unequivocally show that avocado seed extract, which is rich in phenolic derivatives, is a potent nephroprotective agent that inhibits nephrotoxicity induced by Cr (VI) in rabbits.

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Protective Effect of Lactoferrin against Chromium Induced Adverse Renal Changes in Rats: Oxidative Stress Theory

Abstract: This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.

Cited by 4 publications

References 34 publications

Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

Screening models of nephrotoxicity and their molecular mechanism

Ameliorative effect of aqueous avocado seed extract against chromium‐induced oxidative stress and cellular damage in rabbit kidney

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