Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in Helix lucorum

Epstein, O. I.; Stark, Mary B.; Timoshenko, A. Kh.; Gainutdinova, T. Kh.; Гайнутдинов, Х. Л.

doi:10.1007/s10517-007-0179-7

Cited by 5 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An animal experiment has observed that S100 protein‐deficient male mice exhibit increased exploratory activity and reduced anxiety‐related responses 20 . Meanwhile, another animal experiment showed that low‐dose antibodies to S‐100 protein have protective effects on the formation of long‐term sensitization which is considered a neurobiological model of anxiety 21 …”

Section: Introductionmentioning

confidence: 99%

“…20 Meanwhile, another animal experiment showed that low-dose antibodies to S-100 protein have protective effects on the formation of long-term sensitization which is considered a neurobiological model of anxiety. 21 However, no clinical study focused on the association between anxiety symptoms after acute stroke and S-100β has been done. Given the involvement of S-100β in anxiety and the acknowledged elevated serum levels of S-100β in acute stroke patients, 19,22 we aimed to examine whether there is an association between the elevated serum S-100β levels and the development of PSA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Wang

Xiao

et al. 2022

Psychogeriatrics

View full text Add to dashboard Cite

Background: Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after a stroke. Animal experiments have indicated that serum S-100β levels are closely related to anxiety disorder. No clinical study has been done to explore the relationship between serum S-100β levels and anxiety symptoms in patients with acute stroke. The aim of our study was to investigate the association between serum S-100β levels and PSA. Methods: One hundred twenty-six acute stroke patients were recruited and followed up for 1 month. Blood samples were collected within 24 h after admission. The levels of serum S-100β were measured by enzyme-linked immunosorbent assays. Patients with significant clinical symptoms of anxiety and a Hamilton Anxiety Rating Scale score >7 at 1 month after stroke were diagnosed as PSA. Results: Serum S-100β levels in the non-PSA group were lower than the PSA group (838.97 (678.20-993.59) ng/L vs. 961.87 (796.09-1479.59) ng/L, Z = À2.661, P = 0.008). In multivariate analyses, we found that decreased risk of PSA was associated with low tertile serum S-100β levels (≤753.8 ng/L, OR 0.062, 95% CI 0.008-0.475, P = 0.007). Conclusions: Low serum S-100β levels at admission may be associated with the decreased risk of PSA.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Wang

Xiao

et al. 2022

Psychogeriatrics

View full text Add to dashboard Cite

show abstract

Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100

et al. 2008

Self Cite

View full text Add to dashboard Cite

EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12) on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.

show abstract

Changes in Electrical Properties of Command Neurons during Protective Effect of Low Doses of Antibodies to S100 Protein on the Development of Long-Term Sensitization in Helix lucorum

et al. 2009

Self Cite

View full text Add to dashboard Cite

We studied the effect of antibodies to Ca(2+)-binding protein S100 in a dilution of 10(-12) (LAT-S100) on the development of long-term sensitization in Helix lucorum, a neurobiological model of anxious and depressive states. After administration of LAT-S100 preventing the development of long-term sensitization before training, the membrane and threshold potentials in command neurons regulating defense behavior decreased less markedly than during long-term sensitization. It is assumed that the "protective" effect is associated with mechanisms of long-term potential maintenance and changes in intra- and extracellular balance of Ca(2+)-binding protein S100.

show abstract

Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in Helix lucorum

Cited by 5 publications

References 8 publications

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100

Changes in Electrical Properties of Command Neurons during Protective Effect of Low Doses of Antibodies to S100 Protein on the Development of Long-Term Sensitization in Helix lucorum

Contact Info

Product

Resources

About