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EPR-spectroscopy experiments (electron paramagnetic resonance) demonstrated a decrease in NO production in the nervous system and heart of edible snail Helix lucorum after formation of long-term sensitization, a neurobiological model of anxiety and depression. The protective effect of antibodies to Ca(2+)-binding protein S-100 in dilution of 10(-12) on the formation of long-term sensitization was accompanied by partial recovery of NO synthesis in the nervous system and heart. These findings indicate that the imbalance in Ca(2+)-binding protein S-100 can lead to inhibition or modulation of some processes during plastic reorganization in the body and especially during pathological processes.

Injection of antibodies to Ca-binding protein S-100 in a dilution of 10(-12) before the formation of long-term sensitization in Helix lucorum (10 min before the first electric shock) prevented the increase in defense reactions of pneumostome closure and ommatophore withdrawal. Thus, we demonstrated a protective effect of low-dose antibodies to S-100 on the formation of long-term sensitization as a neurobiological model of anxiety and depression.

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