Protective effect of &lt;i&gt; Tamarindus indica&lt;/i&gt; linn against paracetamol-induced hepatotoxicity in rats

Pimple, Bhushan; Kadam, Prasad V.; Badgujar, NS; Ar, Bafna; Patil, M. J.

doi:10.4103/0250-474x.39445

Cited by 28 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of DM to laboratory animals showed elevation of serum levels of direct and total bilirubin compared to control animals, this results are similar to study done by [35]. The increased in total bilirubin in treated rabbits may be an indicator of hyperbilirubinemia-a useful index for the severity of hepatocellular dysfunction [36].…”

Section: Discussionsupporting

confidence: 89%

Protective Effect of Ginger (Zingiber Officinale) and Clove (Syzygium Aromaticum) Against Induced Hepatotoxicity by Dimethoate in Experimental Animals

Ali,

Assakaf

2024

Electron. J. Univ. Aden Basic Appl. Sci.

View full text Add to dashboard Cite

Usage of pesticides is world wide spread have harmful effect on human health via environmental or occupational exposure, that pollute water, soil and food. This experimental study aims to investigate possible antioxidant and protective activities of ginger (Zingiber officinale) and clove (Syzygium aromaticum) aqueous extracts against induced injury of liver hepatocytes using the organophosphate Dimethoate (DM) in rabbits. Thirty adult male rabbits from local market were divided into five groups (6 animals in each). (1) control rabbits, (2) rabbits were given DM (20 mg/kg B. w daily dose 1/20 of half the lethal dose), (3) rabbits were given ginger extract (400 mg/kg B.W) daily dose and then DM, (4) rabbits were given clove extract (100 mg/kg B.W) daily dose and then DM, (5) rabbits were given ginger with clove extracts and then DM as previous dose for 30 days. At the end of the experiment animals were anesthetized and then sacrificed. The blood sample was collected for biochemical analysis. Dimethoate resulted in significant increase in the activity of aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) compared with control. Significantly increased level of both total and direct bilirubin were observed. However, the total protein and albumin were decreased. The ginger and clove extracts either separately or combined in groups 3,4 and 5 showed significantly improvement and decrease activity of liver enzymes AST, ALT and ALP. On the other hand, decreased in total bilirubin compared with DM group were recorded. While increased the serum levels of total protein and albumin were observed. It could be included that ginger and clove extracts were effective in protecting against induced hepatotoxicity by treating liver functions. Therefore, we recommend these two plants by moderate amounts to be added in the daily meals and drinks.

show abstract

Section: Discussionsupporting

confidence: 89%

Protective Effect of Ginger (Zingiber Officinale) and Clove (Syzygium Aromaticum) Against Induced Hepatotoxicity by Dimethoate in Experimental Animals

Ali,

Assakaf

2024

Electron. J. Univ. Aden Basic Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…Paracetamol induced mice liver damage in this study because of the formation of toxic metabolite, NAPQI, which is initially detoxified by conjugation with glutathione to form mercapturic acid [57]. The overdose of paracetamol used in this study caused the glutathione content of hepatocytes exhausted and the hepatocytes become vulnerable to the noxious effects of NAPQI resulting in liver cell necrosis or liver failure that eventually increased the ALT and AST levels [58, 59] which may explain the findings of this study.…”

Section: Discussionmentioning

confidence: 99%

Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant

Kumar

Chen

Kanwar

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The therapeutic potential of Cassia surattensis in reducing free radical-induced oxidative stress and inflammation particularly in hepatic diseases was evaluated in this study. The polyphenol rich C. surattensis seed extract showed good in vitro antioxidant. C. surattensis seed extract contained total phenolic content of 100.99 mg GAE/g dry weight and there was a positive correlation (r > 0.9) between total phenolic content and the antioxidant activities of the seed extract. C. surattensis seed extract significantly (p < 0.05) reduced the elevated levels of serum liver enzymes (ALT, AST, and ALP) and relative liver weight in paracetamol-induced liver hepatotoxicity in mice. Moreover, the extract significantly (p < 0.05) enhanced the antioxidant enzymes and glutathione (GSH) contents in the liver tissues, which led to decrease of malondialdehyde (MDA) level. The histopathological examination showed the liver protective effect of C. surattensis seed extract against paracetamol-induced histoarchitectural alterations by maximum recovery in the histoarchitecture of the liver tissue. Furthermore, histopathological observations correspondingly supported the biochemical assay outcome, that is, the significant reduction in elevated levels of serum liver enzymes. In conclusion, C. surattensis seed extract enhanced the in vivo antioxidant status and showed antihepatotoxic activities, which is probably due to the presence of phenolic compounds.

show abstract

“…A significant hepatoregenerative effect was observed for the aqueous extracts of tamarind leaves, fruits and unroasted seeds (p < 0.05) as judged from the parameters studied. 29 …”

Section: Hepatoprotective Effectmentioning

confidence: 99%

Tamarindus Indica: An Overview

Tariq¹,

Chaudhary²,

Rahman³

et al. 2013

J Biol Sci Opin

View full text Add to dashboard Cite

Tamarindus indica is an essential drug which has been used in Unani system since time immemorial as an effective demulscent, cardiac tonic, stomachic, carminative, digestive, laxative, antiscorbutic, antibilious and antiseptic. It belongs to family Caesalpiniaceae. It is a leguminous tree native to tropical Africa. In India it is found in forest land in Madhya Pradesh, India. In Unani system it is useful for liver, stomach and intestine, constipation, anorexia, polydipsia, indigestion and liver disorders, febrile diseases, bilious disorders and sore throat. The active compounds vitexin, isoorientin, isovitexin, tartaric acid and malic acid are reported to be having anti snake venom, hepatoprotective and analgesic, weight reducing, anti-helminthic and anti-inflammatory activities. In this article an attempt has been made to summarize the enormous classical Unani literature and modern researches on Tamarindus indica.

show abstract

Protective effect of <i> Tamarindus indica</i> linn against paracetamol-induced hepatotoxicity in rats

Abstract: New Antihistaminic Agents: Synthesis and Evaluation of H1-Antihistaminic actions of 3-[(N,N-Dialkylamino)alkyl)-1,2,3,4-tetrahydro-(1H)-thioquinazolin-4(3H)-ones and Their oxo Analogues

Cited by 28 publications

References 8 publications

Protective Effect of Ginger (Zingiber Officinale) and Clove (Syzygium Aromaticum) Against Induced Hepatotoxicity by Dimethoate in Experimental Animals

Protective Effect of Ginger (Zingiber Officinale) and Clove (Syzygium Aromaticum) Against Induced Hepatotoxicity by Dimethoate in Experimental Animals

Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant

Tamarindus Indica: An Overview

Contact Info

Product

Resources

About