Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice

Wang, Junming; Zhang, Yueyue; Zhang, Yasu; Cui, Ying; Liu, Ju; Zhang, Binfeng

doi:10.5582/bst.2012.v6.2.89

Cited by 29 publications

(24 citation statements)

References 35 publications

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“…Результати досліджень, проведених in vitro, свідчать про різні його біологічні ефекти, зокрема протизапальний, антиоксидантний та судинорозширювальний [2]. Завдяки таким властивостям кверцетин успішно застосовується при хворобах печін-ки, покращуючи біомаркери тканини цього органу при ураженнях різного характеру [3,4], а його екстракти, одержані з лікарських рослин, мають виражену гепатопротекторну й жовчогінну дію та впливають на склад жовчі [5,6]. Як і більшість флавоноїдів, кверцетин має низьку біодоступність для організму, що обмежує вивчення особливостей його ефектів in vivo.…”

Section: вступunclassified

Exocrine Function of the Liver in Rats With Exposure to Cоrvitin

Vovkun¹,

Yanchuk²,

Shtanova³

et al. 2016

Fiziol Zh

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Section: вступunclassified

Exocrine Function of the Liver in Rats With Exposure to Cоrvitin

Vovkun¹,

Yanchuk²,

Shtanova³

et al. 2016

Fiziol Zh

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“…The activities of serum ALT and AST are liver injury biomarkers, and their significant elevations denote increased permeability and injury, necrosis of hepatocytes, or a combination of the above [19]. In this study, chronic ingestion of alcohol resulted in increased levels of ALT and AST, which reflected alcohol-induced liver injury.…”

Section: Resultsmentioning

confidence: 85%

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Zhang

Zhou

Wang

et al. 2016

IJMS

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Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm. Syzygium samarangense and Passiflora edulis normalized various biochemical parameters. Solanum muricatum increased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment with Syzygium samarangense and Passiflora edulis could protect liver from the injury of alcohol, while Solanum muricatum could aggravate the damage.

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“…ROS-induced oxidative stress produces proinflammatory cytokines such as tumor necrosis factor α (TNF-α) and interleukin-6, which increase inflammation and lead to apoptosis, steatosis, and fibrosis, thereby inducing severe liver damage (Kim et al, 2008;Ishii et al, 2003;McKillop and Schrum, 2009;Sugimoto and Takei, 2017). Previous studies show that traditional herbal medicines such as cinnamon bark and Lysimachia christinae have protective effects against EtOH-induced liver disease (Kanuri et al, 2009;Wang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Kampo formula “Juzen-taiho-to” exerts protective effects on ethanol-induced liver injury in mice

Fukaya

Nagatsu

Yoshioka

2018

Fundam. Toxicol. Sci.

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-The aim of this study was to investigate whether the Japanese herbal medicine "Juzen-taiho-to (JTX)" has a protective effect on ethanol (EtOH)-induced liver injury. Seven-week-old male ICR mice were orally administered JTX or saline once a day for three days. Twenty-four hours after the last administration, the mice were intraperitoneally injected with EtOH (2 g/kg). The mice in each group were killed 24 hr after EtOH administration and were bled to obtain plasma. The mice injected with EtOH had high plasma levels of alanine aminotransferase and aspartate aminotransferase and lipid peroxidation. Histopathological examination of the liver of mice treated with EtOH revealed an abnormal outline around the central vein, glycogen depletion, and expression of prostaglandin-endoperoxide synthase 2. Pretreatment with JTX prevented the EtOH-induced increase in the levels of alanine aminotransferase and aspartate aminotransferase, lipid peroxidation, and histopathological changes. Our results suggest that JTX exerts protective effects against EtOH-induced liver disease by modulating oxidative stress and inflammatory response.

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Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice

Cited by 29 publications

References 35 publications

Exocrine Function of the Liver in Rats With Exposure to Cоrvitin

Exocrine Function of the Liver in Rats With Exposure to Cоrvitin

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

The Kampo formula “Juzen-taiho-to” exerts protective effects on ethanol-induced liver injury in mice

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