Protective Effect of Microporous Natural Clinoptilolite on Lead-Induced Learning and Memory Impairment in Rats

Nikpey, Ahmad; Kazemian, Hossein; Safari-Varyani, Ali; Rezaie, Marjan; Sabet, Mojgan

doi:10.17795/jhealthscope-10041

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…In lead poisoned mice, the modified ZC reduced the accumulation of lead in the intestine by more than 70% with a protective effect on the brain tissue [47]. In rats intoxicated with organophosphates, ZC was effective in restoring cholinesterase activity at the system level [48,49]. According to some reports, ZC in the intestine could bind to the organophosphate through an interaction with an -OH group or a dipole–dipole interaction and therefore can be excreted in the feces [50].…”

Section: Zeolite Clinoptilolite: a Multifaceted Rockmentioning

confidence: 99%

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

et al. 2019

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Zeolites are porous minerals with high absorbency and ion-exchange capacity. Their molecular structure is a dense network of AlO4 and SiO4 that generates cavities where water and other polar molecules or ions are inserted/exchanged. Even though there are several synthetic or natural occurring species of zeolites, the most widespread and studied is the naturally occurring zeolite clinoptilolite (ZC). ZC is an excellent detoxifying, antioxidant and anti-inflammatory agent. As a result, it is been used in many industrial applications ranging from environmental remediation to oral applications/supplementation in vivo in humans as food supplements or medical devices. Moreover, the modification as micronization of ZC (M-ZC) or tribomechanically activated zeolite clinoptilolite (TMAZ) or furthermore as double tribomechanically activated zeolite clinoptilolite (PMA-ZC) allows improving its benefits in preclinical and clinical models. Despite its extensive use, many underlying action mechanisms of ZC in its natural or modified forms are still unclear, especially in humans. The main aim of this review is to shed light on the geochemical aspects and therapeutic potentials of ZC with a vision of endorsing further preclinical and clinical research on zeolites, in specific on the ZC and its modified forms as a potential agent for promoting human brain health and overall well-being.

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Section: Zeolite Clinoptilolite: a Multifaceted Rockmentioning

confidence: 99%

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

et al. 2019

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“…Applications of orally administration of clinoptilolite have also been evaluated in mice, rats and dogs (Mizik et al 1989;Krasnoperova & Lonin 1999;Abdel-Wahhab et al 2002;Saribeyoglu et al 2011;Nikpey et al 2013).…”

Section: Zeolites As Feed Additive To Improve Fish Growth and Healthmentioning

confidence: 99%

Application of zeolites in aquaculture industry: a review

Ghasemi

Sourinejad

Kazemian

et al. 2016

Reviews in Aquaculture

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116

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Zeolites are microporous crystalline hydrated aluminosilicates, which have found various applications because of their very unique physicochemical characteristics such as ion exchange and adsorption–desorption properties. Significant progress has been made in recent years on applications of these inorganic adsorbents in different industries including agriculture, aquaculture, water and wastewater treatment, air purification and petrochemicals. This review article intends to summarize the published reports on the applications of natural, synthetic and modified zeolites in aquaculture industry. Application of zeolitic materials for water quality improvement of fish farms and fish transportation tanks by selective capturing of ammonia and toxic heavy metals and zeolite application as feed additive to enhance fish growth and promote their health and nutritional parameters are the most important discussed areas. According to the technical data that are discussed in this review, natural and synthetic zeolites should be considered as materials with tremendous potential of applications in the aquaculture industry. Considerable amounts of research works are under way to explore other opportunities for application of zeolites to benefit aquaculture industry.

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“…This process may occur in exchange with contaminants, such as lead (Pb), nickel (Ni), cadmium (Cd), or arsenic (As), due to their affinity toward the crystal framework of zeolite. This property was exploited not only in several industrial applications but also for detoxification effects in vivo , as presented previously in the scientific literature ( 6 – 11 ). Due to this well-documented ion-exchange property, questions arose on the potential effect of clinoptilolite on physiologically relevant minerals in the in vivo applications.…”

Section: Introductionmentioning

confidence: 92%

Clinical Evaluation of a Defined Zeolite-Clinoptilolite Supplementation Effect on the Selected Blood Parameters of Patients

et al. 2022

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The natural clinoptilolite material is an inorganic crystal mineral called zeolite. It has been extensively studied and used in industrial applications and veterinary and human medicine due to positive effects on health. Limited data is available in the scientific literature about its effects on the levels of physiologically relevant minerals in the human organism. Accordingly, we performed a comprehensive and controlled monitoring of the relevant mineral and contaminants levels in human subjects supplemented with a certified clinoptilolite material within three clinical trials with different supplementation regimens. Effects of a registered and certified clinoptilolite material PMA-zeolite on selected mineral and metal levels were determined by standard biochemical methods and inductively coupled plasma mass spectrometry (ICP-MS) in the blood of subjects enrolled in three clinical trials: short-term (28 days, Mineral Metabolism and selected Blood Parameters study MMBP), medium-term (12 weeks, Morbus Crohn study), and long-term (4 years, Osteoporosis TOP study) supplementation. Lower concentrations were observed for copper (Cu) in patients with osteoporosis, which normalized again in the long-term supplementation trial, whereas sodium (Na) and calcium (Ca) levels diminished below the reference values in patients with osteoporosis. In the short- and long-term supplementation trials, increased levels of lead (Pb) were observed in PMA-zeolite-supplemented subjects, which decreased in the continued long-term supplementation trial. Increased levels of aluminum (Al) or Pb attributable to eventual leakage from the material into the bloodstream were not detected 1 h after intake in the short-term supplementation trial. Nickel (Ni) and Al were statistically significantly decreased upon long-term 4-year supplementation within the long-term supplementation trial, and arsenic (As) was statistically significantly decreased upon 12-weeks supplementation in the medium-term trial. Alterations in the measured levels for Na and Ca, as well as for Pb, in the long-term trial are probably attributable to the bone remodeling process. Checking the balance of the minerals Cu, Ca, and Na after 1 year of supplementation might be prescribed for PMA-supplemented patients with osteoporosis.Clinical Trial Registration[https://clinicaltrials.gov], identifiers [NCT03901989, NCT05178719, NCT04370535, NCT04607018].

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Protective Effect of Microporous Natural Clinoptilolite on Lead-Induced Learning and Memory Impairment in Rats

Cited by 9 publications

References 23 publications

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

Application of zeolites in aquaculture industry: a review

Clinical Evaluation of a Defined Zeolite-Clinoptilolite Supplementation Effect on the Selected Blood Parameters of Patients

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