Protective effect of Nardostachys jatamansi in rat cerebral ischemia

Salim, Sofiyan; Ahmad, Muzamil; Zafar, Khan Shoeb; Ahmad, Abdullah Shafique; Islam, Fakhrul

doi:10.1016/s0091-3057(02)01030-4

Cited by 85 publications

(39 citation statements)

References 41 publications

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“…45) May be in the cardiac cells the administration of N. jatamansi could lead to the increase in Na + -K + ATPase activity due to its antilipid peroxidative property by altering the 'SH' group present in its active site leading to restored conformational alterations. The negative inotropic and chronotropic properties as well as the antioxidant potential 46) of some of the constituents of N. jatamansi could have partially prevented the decrease in Na + -K + ATPase and increase in Ca 2+ , Mg 2+ ATPases activity on DOX administration. Lysosomes are a group of cytoplasmic organelles present in numerous animal tissues and are characterized by their acid hydrolases content.…”

Section: Discussionmentioning

confidence: 99%

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Subashini

Arunachalam

Senthilkumar

et al. 2007

JOURNAL OF HEALTH SCIENCE

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Doxorubicin is highly effective in treatment for several forms of cancer. However, doxorubicin induces a cumulative and dose dependent cardiomyopathy that has been ascribed to redox-cycling of the molecule on the mitochondrial complex 1 generating in the process of increased oxidative stress. In the search of new potential cardioprotective agents, the present study is directed to explore the effect of ethanolic extract of Nardostachys jatamansi on the mitochondrial and lysosomal damage induced by doxorubicin in rats. Heart mitochondria were isolated from rats treated with doxorubicin (15 mg/kg, ip) a single dose, exhibited depressed rates of state 3 respiration, low respiratory control ratio (RCR), decreased Oxidative Phosphorylation ratio, Adenosine Triphosphate content and cytochromes (c, c 1 , b, aa 3 ). In addition the doxorubicin given rats showed significant changes in the lysosomal enzymes (Cathepsin-D, Acid phosphatase, β-D-glucoronidase, β-D-galactosidase and β-N-acetyl glucosaminidase) and membrane bound phosphatases. Also myocardial damage, as assessed by ultrastructural changes showed loss of myofibrils, mitochondrial swelling, and cytoplasmic vacuolization. Pretreatment with Nardostachys jatamansi (500 mg/kg body weight orally) for seven days ameliorated the observed abnormalities and significantly prevented the mitochondrial respiration, lysosomal integrity, membrane bound phosphatases and ultrastructural studies in doxorubicin induced rats. These findings suggest that the cardioprotective efficacy of Nardostachys jatamansi could be mediated possibly through its antioxidant effect as well as by the attenuation of the oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Subashini

Arunachalam

Senthilkumar

et al. 2007

JOURNAL OF HEALTH SCIENCE

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“…WL-A (10 micro mol kg {-1} day {-1}, for 13 days) recovered α beta (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) induced memory deficit in mice. At that time, the decline of axons, dendrites and synapses in the cerebral cortex and hippocampus was almost recovered.…”

Section: Neuritic Regeneration and Synaptic Reconstructionsmentioning

confidence: 99%

“…All the alternations induced by ischemia were significantly attenuated by 15 days pretreatment of N. jatamansi (250 mg/kg, orally) and correlated well with histopathology by decreasing neuronal cell death following occlusion and reperfusion. 26 …”

Section: Jatamansimentioning

confidence: 99%

Recent Advances in Ayurvedic Management of Cerebral Palsy Affected Children

Choudhary¹

2014

Int. J. Res. Ayurveda Pharm.

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Cerebral palsy (CP) is a common chronic motor disability among developmental disorder prevalent world widely among pediatric population. It is a group of condition characterized by motor dysfunction due to non progressive brain damage in its early developing period; often accompanied by other features like seizures, behavioral disorder, cognitive impairment and other secondary musculoskeletal problems restricting them from normal independency. The condition poses considerable therapeutic challenge to the treating physician. Currently there is no specific treatment available in modern medical science to counteract the brain insult leading to motor dysfunction in CP. The available therapeutic interventions are mostly symptomatic and costlier. Recent advances in Ayurvedic clinical research have shown increased understanding of etiopathogenesis, its causal pathway of presentation and the value of specific intervention strategies in the management of Cerebral palsy. Ayurveda recommends multiple treatment options for intervention at various levels. Out of them, Panchkarma therapy and oral herbal formulations with properties of anti spasticity, anti convulsant, neurogenerative capacity etc. plays a vital role in the management. This paper provides a critical review on the effect of currently available treatment modalities of Ayurveda that can efficiently manage Cerebral palsy.

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“…아토피피부염을 크게 濕熱俱盛型, 脾虛濕盛型, 血虛風燥型으로 변증 분류하는 . 감송향의 성분은 valeranone, nardosonone, nardostachone, 1-aristilene-2-one, patchouli alcohol, pinene, oleeanolic acid, b-sitisterol 등을 함유하였고 [4][5][6]30) , 감송 향의 효능에 관한 연구는 대부분 신경계와 관련된 연 구로서 뿌리 및 근경 (Nardostachytis rhizoma) 추출물의 진정효과 31) , 신경세포 분화와 관련된 보고 [32][33][34][35] , 급성 췌 장염 억제 16,17,36) , 항산화 및 항스트레스 작용 37,38) , 항박 테리아, 항진균작용 39) , 염증 및 면역에 관한 보고 …”

Section: Tnf-α 생성 조절에 Nj의 효과를 측정하기 위하여unclassified

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

Min

Park²

2012

The Journal of Korean Oriental Pediatrics

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ObjectivesNJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and ResultsWe investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). ConclusionsNJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-α) significantly in vivo and in vitro.

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Protective effect of Nardostachys jatamansi in rat cerebral ischemia

Cited by 85 publications

References 41 publications

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Recent Advances in Ayurvedic Management of Cerebral Palsy Affected Children

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

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