Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Demiryılmaz, İsmail; Turan, Mehmet İbrahim; Kısaoğlu, Abdullah; Gulapoglu, Mine; Yılmaz, İsmayil; Süleyman, Halis

doi:10.1016/j.pharep.2014.02.015

Cited by 49 publications

(33 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Myeloperoxidase is an important enzyme that is found in neutrophils, and it is involved in the ROS production (26,27). In recent studies, in the hepatic I/R injury, it is often stated that as an indicator of neutrophil infiltration, an increase in the MPO activity causes the endothelial dysfunction and inflammation (28,29). Similarly, our study showed that HI increased the MPO values compared with the control group in the liver tissue, while in the SJW group in our study, the MPO activity was substantially reduced, and the results were close to the MPO values of the control group.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…As far as we know, there is no study in the literature on the protective effect of nimesulide against small intestinal mucositis induced by MTX. However, there are some studies demonstrating that nimesulide protects gastric and hepatic tissues against oxidative stress at a dose of 100 mg/kg [8, 28]. It has been reported that nimesulide and its metabolites may prove useful in prevention of acute and chronic free radicals mediated tissue damage [16].…”

Section: Discussionmentioning

confidence: 99%

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

et al. 2016

Self Cite

View full text Add to dashboard Cite

Intestinal mucositis is one of the major problems in the patients receiving cancer treatment. Nimesulide is a drug with antioxidant, antiinflammatory and antiulcer features. We aimed to investigate the effect of nimesulide on the small intestine mucositis induced by methotrexate (MTX) in rats. Experimental animals were divided into the control group, MTX group (MTXG) and nimesulide+MTX administered group (NMTXG) with eight rats per group. The control and MTXG groups were given distilled water by gavage and the NMTXG was given nimesulide 100 mg/kg orally. After one hour, the NMTXG and MTXG rat groups were administered oral MTX 5 mg/kg. This procedure was repeated once a day for 15 days and the rats were sacrificed. The duodenum and jejunum of each rat was removed for the assessment of biochemical markers and histopathological evaluation. Malondialdehyde (MDA) and myeloperoxidase (MPO) levels were significantly higher in the duodenal and jejunal tissues of the animals which received MTX, compared to the control and NMTXG (P<0.001). Also, the levels of total glutathione (tGSH), glutathione reductase (GSHRd), glutathione peroxidase (GSHPx), catalase (CAT) and superoxide dismutase (SOD) were significantly lower in the MTXG (P<0.001) compared to other groups. MTX led to villus and crypt epithelial damage and inflammation containing marked PMNL and eosinophils in the intestinal tissues histopathologically. Whereas, there was only mild irregularities in the villus structures of the NMTXG. Nimesulide protected the small intestines against damage by MTX. Intestinal mucositis caused by MTX may be preventable by co-administered nimesulide.

show abstract

“…64 The toxicity of nimesulide to hepatocytes has been previously observed 65,66 which is attributed mainly to the nitro group in its structure. 67 After reduction, NiNH 2 exhibits reduced toxicity than nimesulide in hepatocytes because nimesulide is a powerful protonophoretic uncoupler and NAD(P)H oxidant.…”

Section: Cell Growth Inhibition By Ha-nimesulidementioning

confidence: 98%

Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo

Jian¹,

Chen²,

Lin³

et al. 2017

IJN

View full text Add to dashboard Cite

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Abstract: Nimesulide at 100mg/kg prevented oxidative liver damage induced with I/R significantly better than at a dose of 50mg/kg. These experimental findings indicate that nimesulide may be useful in the treatment of hepatic I/R damage.

Cited by 49 publications

References 39 publications

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo

Contact Info

Product

Resources

About

Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Abstract: Nimesulide at 100mg/kg prevented oxidative liver damage induced with I/R significantly better than at a dose of 50mg/kg. These experimental findings indicate that nimesulide may be useful in the treatment of hepatic I/R damage.

Cited by 49 publications

References 39 publications

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats

Hyaluronic acid&ndash;nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo

Contact Info

Product

Resources

About

Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo