Protective effect of oral ascorbic acid (vitamin c) against acetaminophen- induced hepatic injury in rats

Adeneye, Adejuwon Adewale; Olagunju, Joseph O.

doi:10.4314/ajbr.v11i2.50704

Cited by 21 publications

(24 citation statements)

References 23 publications

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“…Vitamin C is considered to be an important antioxidant in extracellular fluid; it also guards against aqueous radicals in blood and protects plasma lipids from peroxidative damage caused by peroxyl radicals (BARJA et al, 1994). Furthermore, there are a few studies reporting the antioxidant power of vitamin C against different chemicals-induced oxidative tissue injury (CARR and FREI, 1999;ADENEYE and OLAGUNJU, 2008;HASSANIN et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Matić¹,

Milošević²,

Paunović³

et al. 2016

Kragujevac J Sci

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ABSTRACT. Paracetamol (acetaminophen) is widely used as an over-the-counter analgesic and antipyretic drug. The aim of this study was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β-glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative stress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (RBCs count, Hb concentration, Ht value and WBCs count), suggesting that the paracetamol induced haematotoxicity. Paracetamol reduced serum total protein (TP), albumin and globulin, while increased alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities compared to the control. The results indicate that paracetamol is led to significant decrease in the concentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministration of vitamin C and β-glucan with paracetamol reversed these changes of haematological and biochemical parameters and diminished the toxic effects of paracetamol. The obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β-glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effects and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministration with vitamin C and β-glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.

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Section: Introductionmentioning

confidence: 99%

Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Matić¹,

Milošević²,

Paunović³

et al. 2016

Kragujevac J Sci

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“…Vitamin C has been reported to be nephroprotective (Adeneye and Olagunju, 2009). The antioxidant potentials of vitamin C enable it to scavenge free radicals generated by chemical substances which would have damaged specific cells in the kidney tissues (Markowitz and Perazella, 2005).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of vitamin C against theobromine induced hepatorenal and cardio toxicity in male albino Wistar rats

Bassey¹,

Akpanyung²,

Nwaokonko³

et al. 2019

Int. J. Nutr. Metab.

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The protective effect of vitamin C against theobromine induced toxicity in male albino Wistar rats was investigated. Twenty-five (25) male Wistar rats weighing between 140-160 g were divided into 5 groups with 5 rats in each group. Group 1 served as the control. Group 2 received 700 mg/kg body weight of theobromine daily for 4 days. Group 3 was administered 100 mg/kg body weight of Vitamin C daily for 21 days. Group 4 was intoxicated with 700 mg/kg of theobromine daily for 4 days before treatment with 100 mg/kg of Vitamin C for 21 days while Group 5 received 700 mg/kg of theobromine daily for 4 days and was allowed to recover naturally for 21 days. Biochemical indices of liver, kidney function and lipid profile were assayed using serum. The liver, kidney and heart tissues were used for histological studies. Significant increase (p<0.05) in serum enzyme activities and concentrations of urea, creatinine, total and LDL cholesterol as well as decreased HDL cholesterol concentration were observed in Group 2 compared to the control. Treatment with Vitamin C in Groups 3 and 4 significantly decreased (p<0.05) the activities of the serum enzymes, concentrations of urea, creatinine, total and LDL cholesterol while the concentration of HDL cholesterol was significantly increased when compared to Group 2. Histological evaluation of the liver, kidney and heart sections revealed degenerated cytoarchitecture and inflammation of these tissues following theobromine intoxication. However, the toxic features were observed to resolve in Group 4 when vitamin C was administered while cytoarchitectural degeneration persisted in Group 5. In conclusion, theobromine induced liver, kidney and cardio toxicity with negative modulation of lipid profile while vitamin C ameliorated the toxic effect of theobromine in albino Wistar rats.

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“…Both human Idogun and Ajala (2005) [101] and animal Odigie et al (2007) [102] studies have shown ascorbic acid to be a potent antioxidant which mediates its antioxidant effect by scavenging free reactive oxygen radicals before reaching to the renal. The nephroprotection of ascorbic acid (oral 100-500 mg/kg) in acetaminophen induced nephrotoxic rats which is characterized by marked elevation of serum urea and creatinine, could be due to its inherent antioxidant effect by inhibition of free radicals generation and/or free radical scavenging activity [103].…”

Section: Resultsmentioning

confidence: 99%

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Rabeh¹,

El-Ghandour²

2016

IJNFS

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Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

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Protective effect of oral ascorbic acid (vitamin c) against acetaminophen- induced hepatic injury in rats

Cited by 21 publications

References 23 publications

Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Protective effect of vitamin C against theobromine induced hepatorenal and cardio toxicity in male albino Wistar rats

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

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