Protective Effect of Pinitol against<scp>D</scp>-Galactosamine-Induced Hepatotoxicity in Rats Fed on a High-Fat Diet

Zhou, Yang; Park, Chung-Mu; Cho, Chung-Won; Song, Young‐Sun

doi:10.1271/bbb.70473

Cited by 36 publications

(29 citation statements)

References 31 publications

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“…The administration of D-GalN/LPS also affects the antioxidant capacity of the body; this is in agreement with Zhou et al (2008). The current results also demonstrate that C. myrrha increases hepatic antioxidant activity and decreases the oxidative stress, which are evident by reduced TBARS concentration and enhanced GSH, SOD, and CAT levels.…”

Section: Discussionsupporting

confidence: 91%

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Ahmad

Raish

Ganaie

et al. 2015

Pharmaceutical Biology

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(2015) Hepatoprotective effect of Commiphoramyrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes, Pharmaceutical Biology, 53:12, 1759-1767, DOI: 10.3109/13880209.2015 Results: The administration of D-GalN/LPS increased plasma aminotransferases (174.47 ± 4.5761 and 260.96 ± 1.9839 mkat/l) and total bilirubin levels (1.012 ± 0.0288 mg/dl), which were attenuated by C. myrrha treatment. Hepatic lipid peroxidation activity and nitric oxide content also increased, while the antioxidant activity measured by GSH (0.76 nmol/g protein), SOD (81.91 U/mg protein), and CAT (15.78 U/mg protein) was reduced. Commiphora myrrha provided significant restoration of GSH (0.815 nmol/gm protein), SOD (140.57 U/mg protein), and CAT (27.02 U/mg protein) levels. Furthermore, the acute phase response elicited by D-GalN/ LPS administration enhanced mRNA expressions of TNF-a, IL-6, IL-10, iNOS-2, and HO-1, which were ameliorated by C. myrrha treatment. Discussion and conclusion: These findings indicate that C. myrrha considerably reduces the oxidative stress of D-GalN/LPS-induced hepatic injury via multiple pathways including adown regulation of inflammatory mediators and cytokines. Such a property might be sufficient to combat cellular damage caused by various conditions that resemble fulminant hepatitis and could be of a potential clinical application.

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Section: Discussionsupporting

confidence: 91%

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Ahmad

Raish

Ganaie

et al. 2015

Pharmaceutical Biology

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“…significantly increased the plasma levels of ALT, AST, and ALP compared to the levels in control mice, which is consistent with a number of previous reports [20]. However, pre-treatment with Bidens pilosa extracts for 10 days attenuated the increased levels of ALT, AST, and ALP, and the decreased levels of albumin, total protein, and glutathione.…”

Section: Effect Of Bidens Pilosa Extracts On Biochemical Serum Paramesupporting

confidence: 92%

In vitro and in vivo hepatoprotective activity of extracts of aerial parts of Bidens pilosa L (Asteraceae)

Abdel-Ghany¹,

Barakat²,

Shahat³

et al. 2016

Trop. J. Pharm Res

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“…It is possible that BRI may restore the hepatic CYP2E1 function and lead to a rapid recovery from CCl 4 -induced liver injury. Similar observations regarding a decrease in the CYP2E1 protein content have been found in rats treated with D-galactosamine 31) or CCl 4 . 32) In these studies, an increase in the CYP2E1 protein content following pharmacological manipulation ameliorated the hepatotoxicity after a D-galactosamine or CCl 4 administration.…”

Section: Discussionsupporting

confidence: 86%

Protective Effect of Iridoid Glucosides fromBoschniakia rossicaon Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Ji-shu

Piao

Tian

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Protective Effect of Pinitol againstD-Galactosamine-Induced Hepatotoxicity in Rats Fed on a High-Fat Diet

Cited by 36 publications

References 31 publications

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Hepatoprotective effect ofCommiphora myrrhaagainstd-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

<i>In vitro</i> and <i>in vivo</i> hepatoprotective activity of extracts of aerial parts of <i>Bidens pilosa</i> L (Asteraceae)

Protective Effect of Iridoid Glucosides fromBoschniakia rossicaon Acute Liver Injury Induced by Carbon Tetrachloride in Rats

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