Protective Effect of Potato Peel Powder in Ameliorating Oxidative Stress in Streptozotocin Diabetic Rats

Abstract

The potential of dietary potato peel (PP) powder in ameliorating oxidative stress (OS) and hyperglycemia was investigated in streptozotocin (STZ)-induced diabetic rats. In a 4-week feeding trial, incorporation of potato peel powder (5 and 10%) in the diet of diabetic rats was found to significantly reduce the plasma glucose level and also reduce drastically the polyuria of STZ diabetic rats. The total food intake was significantly reduced in the diabetic rats fed 10% PP powder compared to the control diabetic rats. However, the body weight gain over 28 days was nearly four times greater in PP powder supplemented diabetic rats (both at 5 and 10%) compared to the control diabetic rats. PP powder in the diet also decreased the elevated activities of serum transaminases (ALT and AST) and nearly normalized the hepatic MDA and GSH levels as well as the activities of specific antioxidant enzymes in liver of diabetic rats. The result of these studies clearly establishes the modulatory propensity of PP against diabetes induced alterations. Considering that potato peels are discarded as waste and not effectively utilized, these results suggest the possibility that PP waste could be effectively used as an ingredient in health and functional food to ameliorate certain disease states such as diabetes.

Effects of Hydro-Alcoholic Leaf Extract of Citrullus colocynthis on Biochemical Factors and Histopathological Changes in Streptozotocin-Induced Diabetic Rats

“…In the current study, significantly increased serum levels of TC, TG, and LDL-C but markedly decreased serum level of HDL-C was observed in STZ-induced diabetic rats. These results are consistent with the previous findings (27)(28)(29). Since insulin inhibits the hormone-sensitive lipase, the major reason for disorder of lipid metabolism in diabetic rats is an increased free fatty acid mobilization from adipose tissues into the circulation (30).…”

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

“…In our study, we have noticed significantly increased levels of serum total cholesterol, triglycerides and LDL-cholesterol but markedly decreased level of serum HDL-cholesterol in STZ-induced diabetic rats. These results are in agreement with those obtained by [39,40,57,58]. The abnormal high concentrations of serum lipids in diabetic animals are due mainly to an increase in the mobilization of free fatty acids from the peripheral fat depots, since insulin inhibits the hormone-sensitive lipase [59].…”

Protective Role of Three Vegetable Peels in Alloxan Induced Diabetes Mellitus in Male Mice

“…Because, alloxan induced serum glucose level was nearly normalized by each of the peel extracts, we hypothesize that these peels may have β-cells protective/stimulating activities, as also reported by other workers for some fruit peels and one vegetable peel [14,33,34]. This appears to be more justified for CP that also enhanced insulin concentration.…”

“…In case of CP treated animals a parallel increase in insulin was also observed. This glucose lowering activity of the test peels is somewhat similar to the only available report on vegetable peel that has been shown to be antidiabetic in nature [14]. Also, there was a decrease in serum TC, TG, LDL and VLDL, with an increase in serum HDL concentration, indicating their positive effects on lipid metabolism and antioxidative system.…”

“…Yet, there are limited findings on fruits and vegetable peels. While on fruit peels, some recent reports indicate their possible hypoglycemic and/or antioxidative properties [8][9][10][11], peels of only few vegetables have been reported so far to posses some biological properties, primarily antioxidative values [12][13][14][15]. Therefore, the present study attempted to reveal the preventive role of three hitherto uninvestigated peels (which are otherwise wasted), from the family cucurbitaceae, in the protection of chemically induced diabetes mellitus and associated changes in serum lipids and in hepatic lipid peroxidation.…”