Protective Effect of Pulp Oil Extracted fromCanarium odontophyllumMiq. Fruit on Blood Lipids, Lipid Peroxidation, and Antioxidant Status in Healthy Rabbits

Abstract

The aim of this paper was to compare the effects of pulp and kernel oils of Canarium odontophyllum Miq. (CO) on lipid profile, lipid peroxidation, and oxidative stress of healthy rabbits. The oils are rich in SFAs and MUFAs (mainly palmitic and oleic acids). The pulp oil is rich in polyphenols. Male New Zealand white (NZW) rabbits were fed for 4 weeks on a normal diet containing pulp (NP) or kernel oil (NK) of CO while corn oil was used as control (NC). Total cholesterol (TC), HDL-C, LDL-c and triglycerides (TG) levels were measured in this paper. Antioxidant enzymes (superoxide dismutase and glutathione peroxidise), thiobarbiturate reactive substances (TBARSs), and plasma total antioxidant status (TAS) were also evaluated. Supplementation of CO pulp oil resulted in favorable changes in blood lipid and lipid peroxidation (increased HDL-C, reduced LDL-C, TG, TBARS levels) with enhancement of SOD, GPx, and plasma TAS levels. Meanwhile, supplementation of kernel oil caused lowering of plasma TC and LDL-C as well as enhancement of SOD and TAS levels. These changes showed that oils of CO could be beneficial in improving lipid profile and antioxidant status as when using part of normal diet. The oils can be used as alternative to present vegetable oil.

Hypolipidaemic effects of synbiotic yoghurt in rabbits

“…For the biological study, 32 white New Zealand rabbits (age 8–10 weeks) were obtained from animal house, Department of Pharmacy, University of Sargodha, Sargodha (Pakistan), and were kept under a controlled environment. Before starting the treatment period, these rabbits were adapted for two weeks (Shakirin et al ).…”

“…Two types of diets for feeding of rabbits were prepared. Primary diet was prepared to induce hyperlipidaemia in the rabbits, and secondary diet was formulated for the treatment of hyperlipidaemia by following the formulation as suggested by Shakirin et al () with some modifications (Table ).…”

Kajian Komposisi Kimia, Nilai Nutrisi, Dan Etnofarmakologis Tanaman Genus Kenari

“…Secara etnofarmakologis pemanfaatan spesies kenari yang dilaporkan adalah memiliki aktivitas sebagai antimikroba (Koudou et al 2005;Mogana et al 2011b;Basri & Sandra 2016;Dzotam et al 2016), mengatur kadar glukosa darah (Saari et al 2017;Yeh et al, 2017), sebagai antiaterosklerosis (Shakirin et al 2012a;Shakirin et al 2012b), memiliki aktivitas sebagai antiinflamasi (Leakey et al 2008;Mogana et al 2013a;Mogana et al 2013b), memiliki aktivitas antioksidan Chew et al 2011;Djarkasi et al 2011;Prasad et al 2011;Arenas & Trinidad 2017a; Arenas & Trinidad 2017b) dan sebagai hepatoprotektif (Yeh et al 2017). Pemanfaatan delapan spesies kenari dalam pengobatan dan sebagai sumber nutrisi pangan dirangkum pada tabel 1.…”

“…Aktivitas lain dari CO sebagai antibakteri khususnya terhadap golongan Methicillin-Resistant Staphylococcus aureus atau MRSA dari ekstrak methanol daun CO (Basri & Sandra 2016). Khoo et al (2014) juga melaporkan anthocyanins dari CO memiliki aktivitas cardioprotective yang diuji secara in-vitro, mempunyai aktivitas sebagai antioksidan yang dapat menghambat oksidasi pada sel darah dan bersifat antiaterosklerosis pada kelinci yang diberikan makanan tinggi kolesterol (Shakirin et al 2012a;Shakirin et al 2012b).…”

The effects of fermented wheat powder (Lisosan G) on the blood lipids and oxidative status of healthy rabbits

“…In recent years, the growing attention towards evaluating plant constituents and extracts on a pharmacological basis and the screening of more effective and safe hypocholesterolemic agents constitute an interesting research field (Shakirin et al, 2012;Casamassima et al, 2013;Pozzo et al, 2014).…”