Protective effect of quersetin on oxidative stress in G6PD-deficient erythrocytes in vitro

A moderate protective effect of quercetin against γ-irradiation- and storage-induced oxidative damage in red blood cells for transfusion

“…As mentioned, Miller and Raleigh reported that DMSO, a hydroxyl radical scavenger with high rate of reaction with hydroxyl radicals, was not able to protect but actually stimulated radiation-induced hemolysis in human RBC while ethanol protected (Miller and Raleigh 1983) Although the authors used much higher doses of ionizing radiation (500 Gy) they found that alphatocopherol provided substantial radioprotection for irradiated human RBC. Flavonoids have been described as good antioxidants against free radical-initiated lipid peroxidation and membrane damage in RBC (Ferrali et al 1997, Hou et al 2004, Jamshidzadeh and Mehrabadi 2010. Th ey are believed to exert antioxidant activity due to their stabilizing eff ect on the cell membranes (Margina et al 2012).…”

“…Reiter et al 2009, Vasquez-Garzon et al 2009, Jamshidzadeh and Mehrabadi 2010. Moreover, in a number of studies, quercetin was able to protect RBC against oxidative damage (membrane lipid peroxidation and hemolysis) caused by variety of oxidants, e.g., the hydrophilic free radical initiator AAPH (Kitagawa et al 2004, Asgary et al 2005, Chen and Deuster 2009), phenylhydrazine, acrolein, divicine and isouramil (Ferrali et al 1997) and hydrogen peroxide (Jamshidzadeh and Mehrabadi 2010).…”

“…Quercetin was also able to prevent membrane lipid peroxidation and hemolysis of mouse RBC induced by phenylhydrazine, acrolein, divicine and isouramil (Ferrali et al 1997). Th e protective eff ect of quercetin against hydrogen peroxide-induced oxidative damage in normal and glucose-6-phosphate dehydrogenase-defi cient human RBC has been reported (Jamshidzadeh and Mehrabadi 2010).…”

Antioxidant Activity of Quercetin in a H2O2-Induced Oxidative Stress Model in Red Blood Cells: Functional Role of Band 3 Protein

“…This molecule can directly neutralize ROS/RNS and/or inactivate molecules with pro-oxidant capacity. It is well known that the stability of cell membranes can be positively affected by exogenous antioxidants [ 16 , 17 ] and several studies have showed a protective effect of Q on RBCs [ 42 , 43 , 44 , 45 ]. Because RBCs deliver oxygen to the entire body, the maintenance of a constant amount of RBCs is of pivotal importance for the health of an individual [ 46 ].…”

An Audit on Management of G6PD Deficiency Acute Hemolytic Crisis

“…Although G6PD is a critical enzyme in the redox metabolism of all aerobic cells‚ yet its role in the RBCs is more critical because it is the only source of NADPH which directly and via GSH defends these cells against oxidative stress. G6PD deficiency is an example of hemolytic anemia due to interaction between an intra-corpuscular cause and an extra corpuscular cause‚ because in the majority of cases hemolysis is triggered by an exogenous agent [1][2][3][4][5][6][7][8]. The severity of hemolytic anemia varies among individuals with G6PD deficiency.…”