Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats

Abstract

BACKGROUND/OBJECTIVES:Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary sources that has antioxidant and chemopreventive properties, in arsenic trioxide (As2O3)-induced Male Wistar rats. MATERIALS/METHODS: Adult rats received 3 mg/kg As2O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) was administered (iv.) 1 h before As2O3 treatment. The plasma and homogenization enzymes associated with oxidative stress of rat kidneys were measured, the kidneys were examined histologically and trace element contents were assessed. RESULTS: Rats treated with As2O3 had significantly higher oxidative stress and kidney arsenic accumulation; however, pretreatment with resveratrol reversed these changes. In addition, prior to treatment with resveratrol resulted in lower blood urea nitrogen, creatinine and insignificant renal tubular epithelial cell necrosis. Furthermore, the presence of resveratrol preserved the selenium content (0.805 ± 0.059 μg/g) of kidneys in rats treated with As2O3. However, resveratrol had no effect on zinc level in the kidney relative to As2O3-treated groups. CONCLUSIONS: Our data show that supplementation with resveratrol alleviated nephrotoxicity by improving antioxidant capacity and arsenic efflux. These findings suggest that resveratrol has the potential to protect against kidney damage in populations exposed to arsenic.

Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models

“…Description of the included studies. Of the 260 studies identified by initial searches, 11 met the requirements (15,(39)(40)(41)(42)(43)(44)(45)(46)(47)53) (Fig. 1).…”

“…For certain studies, there were defects in certain aspects. For the measurement of TNF-α, the specimens collected in one study was lung tissue rather than plasma (39). Although resveratrol could significantly reduce the expression of TNF-α in animal models of sepsis-induced multiple organ injury, TNF-α had no exact mean values in some studies (40)(41)(42), but corresponding data was displayed in a figure or table.…”

“…Of the 8 studies, 3 studies did not give an exact mean value (40)(41)(42). Although the other excluded study gave an exact mean, the collected specimens were lung tissue rather than plasma (39). These studies all mentioned that resveratrol could significantly reduce the expression of TNF-α, but due to the lack of mean values they could not be used for the meta-analysis.…”

“…M DA. Five of the included studies measured MDA (15,(39)(40)(41)44), however one did not have a specific mean (15). Of the 5 studies, 2 measured MDA in multiple organs (spleen, liver, kidney, lung, small intestine, colon) (40,41), Figure 1.…”

“…Finally, articles containing at least one outcome indicator were included, amounting to 11 articles. 1 measured MDA in lung and kidney (15), 1 only in the heart (44) and 1 in lung tissue (39). Analysis of the data from the 4 eligible studies is shown in Fig.…”