Protective Effect of Rosa damascena Against Aluminum Chloride-Induced Oxidative Stress

Abstract

Aluminum is considered an essential element endowed with toxicity potentials in human and animal. Thus, intoxication with aluminum can lead to oxidative stress, which is associated with oxidative damage to various macromolecules. Moreover, antioxidants from natural sources can play an important role in human health. Accordingly, the purpose of this study was to investigate the protective effect of Rosa damascena extract against aluminum-induced oxidative stress. In this study, 60 male rats were randomly divided into six groups and then they were given daily aluminum chloride and Rosa damascena extract. After 8 weeks of treatment, the levels of total antioxidant and malondialdehyde, as well as antioxidant enzymes including catalase, glutathione S-transferase, and myeloperoxidase, were measured in all experimental groups in this study. A significant increase was found in the total antioxidant level in the rats treated with aluminum, Rosa damascena extract, and aluminum plus Rosa damascena extract compared with those in the control group. Also, malondialdehyde levels were not significantly different in all the studied groups. Glutathione S-transferase activity levels in rats receiving the Rosa damascena extract as well as rats taking aluminum with Rosa damascena extract increased significantly compared with the ones in the control group. Catalase activity in the aluminum-treated group also increased significantly compared with the rates in the control group (31.34 ± 4.50 U/gHb vs. 14.04 ± 6.17 U/gHb, p = 0.014). Furthermore, myeloperoxidase activity in the aluminum-treated group increased significantly compared with the control group (49.47 ± 5.12 U/L vs. 25.28 ± 2.18 U/L, p < 0.001). The Rosa damascena extract could improve antioxidant capacity and reduce oxidative conditions in rats receiving aluminum chloride as evidenced by assays of the ferric reducing ability of plasma and activity of antioxidant enzymes. According to the findings of this study, it can be concluded that the Rosa damascena extract with its high antioxidant content is able to exert a protective effect against aluminum-induced oxidative stress.

Chemical Characterization of Taif Rose (Rosa damascena) Methanolic Extract and Its Physiological Effect on Liver Functions, Blood Indices, Antioxidant Capacity, and Heart Vitality against Cadmium Chloride Toxicity

“…Another important constituent of the R. damascena extract is quercetin, which is a known, potent antioxidant and anti-inflammatory agent and greatly enhances immune capacity during pandemics such as the COVID-19 pandemic [ 43 , 44 , 45 , 46 ]. Eugenol, which is used as an ingredient in teas, perfumes, flavourings, and essential oils, was also detected [ 47 ]. It is also used as a local antiseptic and anaesthetic and can be used in dentistry applications.…”

Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

“…The functions of Cholinergic in the central nervous system depend principally on acetylcholine. The change in the function of cholinergic neurotransmission can be due to aluminum chloride [51]. In this study, a significant increase in Acetylcholine level was reported in Aluminium-exposure group compared to the control group while the non-significant change in dopamine and norepinephrine was record in Aluminium exposure group.…”

Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

“…It has recently been demonstrated that polyphenolic fractions of rose oil distillation water has decreased gene-expression and cellular secretion of proinflammatory cytokines like IL-6 and IL-1β in vitro (26). In a study was reported that rosa damascena extract enhanced antioxidant capacity and decreased oxidative markers in aluminum chloride-induced oxidative stress condition in rats (27). Moreover it was demonstrated that Rosa damascena hydroalcoholic extract decreased the raising in liver fat accumulation and hepatic enzymes in rat model of nonalcoholic fatty liver disease (28).…”