Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

Alhoshani, Ali; Hafez, Mohamed M.; Husain, Sufia; Al-sheikh, Abdel Malek; Alotaibi, Moureq R.; Rejaie, Salim S. Al; Alshammari, Musaad A.; Almutairi, Mashal M.; Al‐Shabanah, Othman A.

doi:10.1186/s12882-017-0601-y

Cited by 87 publications

(65 citation statements)

References 70 publications

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“…Also emodin which is found in rheum genus has nephroprotective effects against metals by inhibition of proliferation of renal mesangial cells (MSCs) and thus lower cellular DNA [25]. In addition, rutin as an active ingredient in rheum genus [26] showed nephroprotective effect against cisplatin [27] and hexachlorobutadien [6]. Isolated anthraquinones from rheum genus revealed protective effects against mercuric chloride in rats [28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

et al. 2019

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Hexachlorobutadien is nephrotoxic agent in rodents. The mechanism of toxicity includes generation of free radicals, depletion of thiol groups and production of toxic metabolites. Antioxidant compounds may reduce HCBD-nephrotoxicity. In this research we investigated the effect of Rheum turkeatanicum extract against HCBD-toxicity. The animals were divided to 4 groups which were including control (saline, 1 mL/kg), HCBD (100 mg/kg) and treatment groups which received extract at doses 100 and 200 mg/kg. The extract were administered as intraperitoneally (i.p.) 1 h before HCBD injection (i.p.). The animals were anesthetized by ether, 24 h after HCBD administration. The results showed elevation of serum creatinine, serum urea, urinary protein, urinary glucose, malondialdehyde levels in kidney and reduction of thiol in kidney by HCBD. The histopathological studies showed that there was apoptosis and necrosis in HCBD treated groups. Administration of R.turkestanicum reduced HCBD toxicity. The extract reduced hitopathological changes in kidney. It may be concluded that the nephroprotective effect of extract may be due to different mechanisms such as antioxidant activity or by decreasing the toxic metabolites of HCBD or inhibition of enzymes which are involved in the bioactivation of HCBD such as glutathione-S-transferase (GST) or cysteine-S-conjugate β-lyase.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

et al. 2019

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“…Hesperidin treatment showed renoprotective effect against gentamicin and this effect may be due to its antioxidant properties [96] . Nephroprotective effect of rutin indicated by study showed rutin administration attenuated cisplatin-induced alteration changes in the kidney [97] . carcinoma.…”

Section: Catalase Is a Hemoprotein And It Protects Cells From The Accmentioning

confidence: 98%

“…The elevated serum creatinine and BUN levels induced by cisplatin were significantly restored to their normal levels as in control group by rutin. The rutin protective effect against nephrotoxicity can be attributed to its antioxidant and anti-inflammatory effect on ROS and some cytokines may be involved in the glomerular filtration rate damage [86] . LDH , a cytoplasmic marker enzyme is a known indicator of the cell and tissue damage by toxic compounds [87] .…”

Section: Catalase Is a Hemoprotein And It Protects Cells From The Accmentioning

confidence: 99%

Assessment of antiproliferative activity of Capparis spinosa L extract against Ehrlich ascites carcinoma in Swiss albino mice

Mohammed

Gurigis

Gamal

2018

Biochemistry Letters

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Background: Medicinal plants have been known as one of the most important therapeutic agents for cancer treatment and prevention. Capparis spinosa L is a multipurpose plant that contains different bioactive phytochemicals including phenols and flavonoids.Aims: In the present study we explore the invivo antitumor activity of Capparis spinosa L extract and most potent constituents rutin and hesperidin against Ehrlich ascites carcinoma (EAC). Also study the side effect of treatments on different organs (liver, kidney and heart). Material and method: The antitumor effect was assessed by evaluating tumor volume , tumor cell count , survival time and increase in life span of EAC bearing mice. We assessed the effect of Capparis spinosa L extract , rutin and hesperidin on the level of malonaldialdhyde (MDA) and Catalase activity. Also, we estimated their effect on Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) , Albumin , urea , creatinine ,Lactate dehydrogenase activity (LDH), Creatine Kinase-MB activity (CK-MB). Apoptosis was assessed by BCL2 and caspase3 activity. Results : The Capparis spinosa L extract , rutin and hesperidin showed significantly decreased (p<0.001) in the volume of the EAC and in the count of EAC cells and increase the life span of EAC bearing mice. The treatment with Capparis spinosa L extract , rutin and hesperidin showed significantly decreased (p<0.001) the lipid peroxidation marker (MDA) and recovered catalase activity towards normal as compared to positive control. We founded that Capparis spinosa L extract , rutin and hesperidin treatment induced apoptosis demonstrated by an increased in Caspase 3 activity and decreased in BCL2 .The treatment of Capparis spinosa L extract , rutin and hesperidin significantly reduced the elevated levels of ALT , AST ,LDH ,CK-MB,Urea and Creatinine in positive control as compared with negative control. Also, they showed protection for both liver and kidney histopathologically. Conclusions: The present study demonstrated that Capparis spinosa L extract , rutin and hesperidin have potent antitumor activity against Ehrlich ascites carcinoma. The anti-tumor mechanism may be mediated by preventing oxidative damage and induction of apoptosis.

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“…Rutin is a flavonoid with many pharmaceutical effects: antioxidant (Casa et al, 2000), antiinflammatory, antiviral, antibacterial, antitumor, antialergic, antithrombotic (Janbaz et al, 2002), hypolipidic, cytoprotective, (Yang et al, 2008) and antiulcer (Casa et al, 2000). Rutin reduces the toxicity caused by paracetamol and CCl4 in the liver, (Janbaz et al, 2002) and in Cisplatin treatment, the antioxidant activity explains the nephroprotective effects (Alhoshani et al, 2017) the present study aimed to study the possible protective effect of rutin against nephrotoxicity induced by cisplatin in rats. METHODS Forty male Wistar albino rats were randomly divided into 4 groups.…”

Section: Resultsmentioning

confidence: 96%

Mahonia Aquifolium Flowers Extract Effects in Acute Experimental Inflammation

Cecan¹,

Pârvu²,

Pârvu³

et al. 2018

BUASVMCN-FST

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Natural products were proved to have inhibitory effect on the nitro-oxidative stress. The aim of the study was to evaluate the effect of Mahonia aquifolium (MA) flowers extract upon nitro-oxidative stress in acute experimental inflammation. The extract was prepared by repercolation method. Acute experimental inflammation was induced with turpentine oil (0,6ml/kg b.w. i.m.). MA extract was given for 7 days. Were used 6 groups (n=5) of male Wistar rats: Groups 1-3 were with acute inflammation and treated with MA dilutions (100%, 50%, 25%); Group 4 was acute inflammation control; Group 5 was negative control; Group 6 was acute inflammation treated with diclofenac (10mg/kg b.w. p.o). In day 8 nitro-oxidative stress was evaluated by measuring serum nitrites and nitrates (NOx), Total oxidative stress (TOS), Total antioxidant capacity (TAC), Oxidative stress index (OSI), Malondialdehyde (MDA) and Thiols (SH). MA reduced OSI and TOS, increased SH, and had no important effect on TAC, NO and MDA. Compared to MA, Diclofenac was a stronger inhibitor of TOS and OSI, and had a smaller effect on SH. Mahonia aquifolium flowers extract had inhibitory effect on the oxidative stress, without influencing NO and lypoperoxides production, the effect being smaller than that of Diclofenac.

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Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats

Cited by 87 publications

References 70 publications

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

Evaluation of Rheum Turkestanicum in Hexachlorobutadien-Induced Renal Toxicity

Assessment of antiproliferative activity of Capparis spinosa L extract against Ehrlich ascites carcinoma in Swiss albino mice

Mahonia Aquifolium Flowers Extract Effects in Acute Experimental Inflammation

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