Protective effect of sericin peptide against alcohol-induced gastric injury in mice

Li, Yougui; Ji, Dong-Feng; Lin, Tao; Zhong, Shi; Hu, Gui-Yan; Chen, Shi

doi:10.1097/00029330-200810020-00026

Cited by 35 publications

(16 citation statements)

References 15 publications

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“…Li et al [66, 72] observed a protective effect of sericin in hepatic and gastric injuries caused by alcohol in mice. The treated animals showed higher alcohol elimination in urine, and this lowers concentration in serum.…”

Section: Sericin Properties and Biomedical Applicationsmentioning

confidence: 99%

Silkworm Sericin: Properties and Biomedical Applications

Kunz

Brancalhão

Ribeiro

et al. 2016

BioMed Research International

334

261

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Silk sericin is a natural polymer produced by silkworm, Bombyx mori, which surrounds and keeps together two fibroin filaments in silk thread used in the cocoon. The recovery and reuse of sericin usually discarded by the textile industry not only minimizes environmental issues but also has a high scientific and commercial value. The physicochemical properties of the molecule are responsible for numerous applications in biomedicine and are influenced by the extraction method and silkworm lineage, which can lead to variations in molecular weight and amino acid concentration of sericin. The presence of highly hydrophobic amino acids and its antioxidant potential make it possible for sericin to be applied in the food and cosmetic industry. The moisturizing power allows indications as a therapeutic agent for wound healing, stimulating cell proliferation, protection against ultraviolet radiation, and formulating creams and shampoos. The antioxidant activity associated with low digestibility of sericin that expands the application in the medical field, such as antitumour, antimicrobial and anti-inflammatory agent, anticoagulant, acts in colon health, improving constipation and protects the body from obesity through improved plasma lipid profile. In addition, the properties of sericin allow its application as a culture medium and cryopreservation, in tissue engineering and for drug delivery, demonstrating its effective use, as an important biomaterial.

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Section: Sericin Properties and Biomedical Applicationsmentioning

confidence: 99%

Silkworm Sericin: Properties and Biomedical Applications

Kunz

Brancalhão

Ribeiro

et al. 2016

BioMed Research International

334

261

View full text Add to dashboard Cite

show abstract

“…Zhaorigetu et al demonstrated that sericin protein exerts a suppressant effect on skin cancer (12) and colon cancer (13), while Li et al demonstrated a protective effect of sericin and sericin peptide against alcohol-induced liver and gastric injuries in mice (14,15). Aramwit et al (16) and Ohnishi et al (17) identified a cell-protective effect of sericin on collagen and nitric oxide, and cryopreserved rat islets, respectively.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities of two sericin proteins extracted from cocoon of silkworm (Bombyx mori) measured by DPPH, chemiluminescence, ORAC and ESR methods

et al. 2014

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Recent efforts have focused on the use of sericin proteins extracted from cocoons of silkworm as a healthy food source for human consumption. In this study, we focused on the antioxidative properties of sericin proteins. The antioxidative properties were measured in sericin proteins extracted from the shell of the cocoon, designated hereafter as white sericin protein and yellow-green sericin protein, as well as bread without sericin protein and bread to which white sericin powder had been added using four measurement methods: 1,1-Diphenyl-2-picrylhydrazyl (DPPH), chemiluminescence, oxygen radical absorbance capacity (ORAC) and electron spin resonance (ESR). High antioxidative properties of sericin proteins were indicated by all four methods. A comparison of the two types of sericin proteins revealed that yellow-green sericin protein exhibited high antioxidative properties as indicated by the DPPH, chemiluminescence and ORAC methods. By contrast, a higher antioxidative property was determined in white sericin protein by the ESR method. Consequently, our findings confirmed that sericin proteins have antioxidative properties against multiple radicals. In addition, the antioxidative property of bread was enhanced by the addition of sericin powder to the bread. Therefore, findings of this study suggest that sericin proteins may be efficiently used as beneficial food for human health.

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“…It has been considered that these changes in mitochondrial physiology induce the morphological alterations and decreased activity observed in the mitochondria of bovine oocytes and embryos (Nabenishi et al, ; Rivera, Kelley, Erdos, & Hansen, ). Conversely, sericin has been found to restore the normal parameters of antioxidant enzymes in mice and to serve a protective function by reducing ROS production and lipid peroxidation, as well as recovering cell morphology and preserving mitochondrial activity during hepatic and gastric injuries caused by alcohol (Li, Ji, Chen, & Hu, ; Li, Ji, Lin et al, ). Based on these findings, we hypothesized that sericin would alleviate the detrimental effects of HS on the mitochondrial function by maintaining the physiological level of ROS, resulting in the improvement of developmental competence in HS embryos.…”

Section: Discussionmentioning

confidence: 99%

Sericin enhances the developmental competence of heat‐stressed bovine embryos

Khatun

Egashira

Sakatani

et al. 2018

Molecular Reproduction Devel

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We investigated the effects of sericin on the developmental competence of bovine embryos exposed to heat stress (HS). Putative zygotes were cultured with sericin and subjected to HS (40.5°C for 6 hr) on Day 2 or 7 followed by continuous culture at 38.5°C until Day 8. Day 2 HS significantly decreased blastocyst development on Day 8 as well as mitochondrial activity, and significantly increased the amount of intracellular reactive oxygen species and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL)-positive cells, whereas Day 7 HS only significantly decreased mitochondrial activity and increased the number of TUNEL-positive cells in Day 8 blastocysts. These detrimental effects were neutralized by sericin supplementation. Next, to investigate the potential production of blastocysts with high viability in terms of thermotolerance, embryos were cultured with sericin until Day 7, and then exposed to HS in the sericin-free medium. TUNEL-positive cell numbers were significantly lower in blastocysts produced by sericin culture than in control blastocysts. Transcript abundance for HSPA1A and BAX was significantly decreased but IFNT2 levels were increased in blastocysts produced by sericin culture. In conclusion, these findings demonstrate the anti-oxidative and anti-apoptotic activities of sericin, and the potential use of sericin to produce embryos with high viability in vitro.

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Protective effect of sericin peptide against alcohol-induced gastric injury in mice

Cited by 35 publications

References 15 publications

Silkworm Sericin: Properties and Biomedical Applications

Silkworm Sericin: Properties and Biomedical Applications

Antioxidant activities of two sericin proteins extracted from cocoon of silkworm (Bombyx mori) measured by DPPH, chemiluminescence, ORAC and ESR methods

Sericin enhances the developmental competence of heat‐stressed bovine embryos

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