Protective effect of sesame (sesamum indicum) seed oil against hypercholesterolemic in sprague-dawley male rats

Abstract

List of abbreviations SSO-Sesame seed oil HDL-C-High-density lipoprotein Cholesterol TG-Triglycerides LDL-C-Low-density lipoprotein Cholesterol TC-Total cholesterol VLDL-C-Very low-density lipoprotein Cholesterol AHA-American heart association CVDs-Cardiovascular Diseases

Sesamum indicum diet prevents hyperlipidemia in experimental rats

“…This might be indicative of the hypolipidemic potency of SI as its administration on the hyperlipidemic rats in this study had a significant weight-reducing effect comparable to that obtained with atorvastatin treatment. The weight-reducing effect of SI on hyperlipidemic rats observed in this study is consistent with the reports of Nandakumaran et al, 2015 , Aslam et al, 2020 who observed a substantial decrease in rats’ body weight after 30- and 42-days continuous administration of SI oil.…”

“…Sesame seeds ( Sesamum indicum ) a member of the Pedaliaceae family is regarded as the oldest oil-yielding seed crop known to humanity. The oil seed is cultivated and obtained in high yields across the tropical and subtropical regions of Africa (Nigeria, Ethiopia, Burkina Faso, Somalia, Tanzania and Uganda), Asia (China, India, Myanmar, Korea, Russia and Turkey) and America (Mexico and South America) ( Nzikou et al, 2009 ) due to its wide spectrum of pharmacological activities, therapeutic and nutritional importance which includes cholesterol-lowering effect and prevention of high blood pressure, attributable to the presence of two unique substances in the seed: sesamin and sesamolin ( Aslam et al, 2020 ). In many parts of the world, sesame seed has been utilized in the cure/prevention of various illnesses due to its high level of mono- and polyunsaturated fatty acids (omega-3 and omega-6 fatty acids), vitamin E, phytosterols, fiber, and other nutraceutical components ( Andargie et al, 2021 , Asgary et al, 2013 , Kumar et al, 2013 ).…”

Influence of Virgin Coconut and Sesame Oils on Diabetic Male Rats

“…In another study, the result of study SSO consumption appears to improve glycaemic control markers in males and improve functions of liver and kidney compared with CO in patients with type 2 diabetes (Raeisi-Dehkordi et al, 2020). Sesame seeds can improve lipid profile by help on reduce or decrease on total cholesterol, LDL, VLDL and triglycerides of rats and increase on HDL of rats (Aslam et al, 2020). Consumption of SSO positively influences blood glucose, oxidative stress, hepatica antioxidant enzyme activity, and cardiac, liver, and kidney function in adolescent participants with T2DM (Aslam et al, 2017).…”

“…Similar results were found by Rezq, (2019). Also, Vishwanath et al, (2012), found that sesame oil consumption helped in hypertensive patients remarkably reduced oxidative stress and simultaneously increases glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase, this action effect on increase on catalase level decrease on malondialdehyde (MDA) (Aslam et al, 2020). -Means with different superscript are significantly different at (P<0.05).…”

Diabetes and sesame: an insight about the benefits of sesame (Sesamum indicum L.) in curing diabetes

“…[59][60][61][62][63][64] Hence it was concluded that Sesame oil showed synergistic impact with glibenclamide and can give a protected and successful alternative for the medication combination that might be exceptionally valuable in clinical practice for the effective improvement of hyperglycemia. Aslam et al 65 carried out the study to investigate the protective impact of sesame seed oil (SSO) separated from Til-06 sesame assortment in Sprague-Dawley male rodents against the administration of hypercholesterolemia, the current two-stage study was led. In the main stage, oil was taken out from the sesame seeds (Til-06) and physicochemical examination was completed to discover the substance of oil following by the assessment of the quality ascribes of removed oil.…”