Protective effect of Shemamruthaa on lipids anomalies in 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinoma-bearing rats

Nandhakumar, E.; Purushothaman, Ayyakkannu; Sachdanandam, Panchanatham

doi:10.1007/s00044-014-0921-4

Cited by 10 publications

(9 citation statements)

References 59 publications

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“…Administration of BAEPS improved lipid profile of DMBA-induced breast cancer rats toward normalization. The explained results are in agreement with those of Nandhakumar et al 47 and Ibrahim et al 9 who demonstrated a hyperlipidemic effect of DMBA administration in breast cancer female rats. Meanwhile, BAEPS administration exhibited hypolipidemic effect.…”

Section: Discussionsupporting

confidence: 93%

“…Meanwhile, BAEPS administration exhibited hypolipidemic effect. These data were in accordance with those published by Nandhakumar et al 47 on Shemamruthaa (a Siddha formulation which constitutes Hibiscus rosa sinensis, Emblica officinalis , and Honey in define ratio) and Arroyo-Acevedo et al 48 on Piper aduncum capsule. The disturbance in lipid profile of DMBA-female rats may reveal to the secretion of proinflammatory cytokines.…”

Section: Discussionsupporting

confidence: 92%

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Acidic Exopolysaccharide Produced from Marine Bacillus amyloliquefaciens 3MS 2017 for the Protection and Treatment of Breast Cancer

Ibrahim

Youness

Mahmoud

et al. 2020

Breast Cancer�(Auckl)

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Purpose: This study was planned to investigate the anti-breast-cancer property of acidic exopolysaccharide produced from marine Bacillus amyloliquefaciens 3MS 2017 (BAEPS) in an animal model, which previously showed in-vitro anti-breast-cancer activity, by studying its potential participation in various targeted mechanisms. Methods: Mammary carcinoma in female Sprague-Dawley rats, both in prophylactic and in curative designs, was chemically induced using 7,12-dimethylebenz-(a)-anthracene (DMBA). B. amyloliquefaciens 3MS 2017 anti-breast-cancer property was evaluated by studying its effects on cancer-growth-rate-limiting enzymes (aromatase and Na+/K+ ATPase), sexual hormones (estrogen and progesterone), antioxidant and inflammatory biomarkers (cyclooxygenase-1; COX-1 and cyclooxygenase-2; COX-2). The incidence of breast cancer by DMBA was dependent on the level of carcinoembryonic antigen (CEA) and aromatase. Results: 7,12-Dimethylebenz-(a)-anthracene female rats were characterized by a significant increase in cancer-related biomarkers with an increase of oxidative stress biomarkers, in comparison with the negative control. Potent BAEPS anticancer activity on DMBA rats was exhibited either as a prophylactic or as a curative agent, which appeared via restoring the aromatase and Na+/K+ ATPase subunits levels and CEA close to the normal level. Besides, BAEPS modulated a sexual hormone, in comparison with the cancer control group ( P ⩽ .05). B. amyloliquefaciens 3MS 2017 selectively inhibited COX-2 in parallel with promising antioxidant properties. The curative characters of BAEPS were more promising than the prophylactic. Conclusion: The anti-breast-cancer characters accompanied with a good safety margin may be attributed to its inhibitory effect on cancer-growth-rate-limiting enzymes, estrogen production, COX-2 level and lipid peroxidation, concurrent with enhancing COX-1 level, progesterone production, and antioxidant status.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Acidic Exopolysaccharide Produced from Marine Bacillus amyloliquefaciens 3MS 2017 for the Protection and Treatment of Breast Cancer

Ibrahim

Youness

Mahmoud

et al. 2020

Breast Cancer�(Auckl)

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“…Earlier reports from our laboratory have demonstrated that Shemamruthaa exerts profound anticancer activity through its role in reinstating the normal levels of glycoprotein components, revitalizing the membrane stability, restoring antioxidant status, regulating lipid profile and lipid-metabolizing enzymes and inducing apoptosis in 7,12-dimethylbenz[a]anthraceneinduced cancer-suffering animals. [25][26][27][28][29] In the present study, we show that Shemamruthaa induces cytotoxicity and activates intrinsic pathway of apoptosis, through a p 53 independent mechanism in MDA-MB-231 breast cancer cells. Shemamruthaa also interferes with progression of tumours in breast cancer rat models and results in the extended life span without affecting other cellular functions and body weight.…”

mentioning

confidence: 54%

“…[25][26][27][28][29] In the present study, we show that Shemamruthaa induces cytotoxicity and activates intrinsic pathway of apoptosis, through a p 53 independent mechanism in MDA-MB-231 breast cancer cells. Shemamruthaa also interferes with progression of tumours in breast cancer rat models and results in the extended life span without affecting other cellular functions and body weight.…”

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confidence: 99%

Shemamruthaa, a Herbal Formulation Induces Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Rats

Purushothaman

Nandhakumar

Shanthi

et al. 2016

J Evid Based Complementary Altern Med

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Phytochemicals present in plants are more effective than their individual constituents in preventing cancer through synergetic effects. From this perspective, Shemamruthaa, a herbal formulation was evaluated with a view to potentiate more intense anticancer property. This study investigates the anticancer activity of Shemamruthaa in breast cancer (MDA-MB 231) cell lines and its cancer therapeutic potential in 7,12-dimethylbenz[a]anthracene induced breast cancer rats. Results of MTT, trypan blue, and apoptotic marker assays suggested that Shemamruthaa can induce cytotoxicity in cancer cells, in a concentration- and time-dependent manner. Oral administration of Shemamruthaa effectively suppressed the tumor progression as evidenced by decrease in tumor volume and modulation of oxidant-antioxidant status and resulted in extended life span. Gas chromatography-mass spectrometry and high-performance liquid chromatography analysis of Shemamruthaa revealed the presence of pyrogallol, 5-hydrxoymethylfurfural, trilinolein, and flavonoids. Finally, we show that Shemamruthaa contains potential anticancer agents acting either singly or in combination against breast cancer cell proliferation.

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“…[21][22][23][24][25] The present study investigates the molecular mechanism underlying the anticancer effects of SM in DMBA-induced mammary carcinoma bearing rats.…”

mentioning

confidence: 99%

Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats

Purushothaman

Nandhakumar

Shanthi

et al. 2015

J Evid Based Complementary Altern Med

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A herbal preparation, Shemamruthaa (SM), was formulated to investigate the molecular mechanism by which it exhibits anticancer effects in mammary carcinoma bearing rats. Female Sprague-Dawley rats were used for the study, and mammary carcinoma was induced by administration of 7,12-dimethylbenz(a)anthracene, intragastrically. After 3 months of induction period, the rats were treated with SM (400 mg/kg body weight) for 14 days. Our study shows that SM-treated mammary carcinoma rats showed regression in tumor volume with concomitant increase in p(53), Bax, caspase-3, and caspase-9 mRNA and protein levels compared with mammary carcinoma-induced rats. Proliferating cell nuclear antigen and anti-apoptotic Bcl-2 were markedly increased in mammary carcinoma-induced rats, whereas the SM treatment significantly decreased the expression of these proteins. The expression pattern of apoptotic signaling molecules analyzed in the present study signifies the therapeutic efficacy of SM against breast cancer.

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Protective effect of Shemamruthaa on lipids anomalies in 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinoma-bearing rats

Cited by 10 publications

References 59 publications

Acidic Exopolysaccharide Produced from Marine Bacillus amyloliquefaciens 3MS 2017 for the Protection and Treatment of Breast Cancer

Acidic Exopolysaccharide Produced from Marine Bacillus amyloliquefaciens 3MS 2017 for the Protection and Treatment of Breast Cancer

Shemamruthaa, a Herbal Formulation Induces Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Rats

Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal Preparation, in 7,12-Dimethylbenz(a)Anthracene-Induced Breast Cancer Rats

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