Protective effect of surface-modified berberine nanoparticles against LPS-induced neurodegenerative changes: a preclinical study

Soudi, Salma A; Nounou, Mohamed Ismail; Sheweita, Salah A.; Ghareeb, Doaa A.; Younis, Layla K.; El-Khordagui, Labiba K.

doi:10.1007/s13346-019-00626-1

Cited by 35 publications

(14 citation statements)

References 81 publications

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“…Neuroprotective effects of berberine have also been confirmed in animal models of Alzheimer's disease [83]. Berberine nanoparticles have shown protective effect against LPS-induced neurodegenerative changes [84]. Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines [85].…”

Section: Berberine From Berberis Aristata DCmentioning

confidence: 96%

Bioactive Molecules from Indian Medicinal Plants as Possible Candidates for the Management of Neurodegenerative Disorders

Lal¹,

Lal²

2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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The present review gives an account of various bioactive molecules obtained from Indian medicinal plants for neurological degenerative disorders. Emphasis is laid on their correlation with the plants used in traditional system of medicine in India. The methodology involved in present review was enlisting of medicinal plants used for neurodegenerative disorders followed by their chemistry. A correlation with the chemical constituents and their recent findings has been done. Many medicinal plants such as Aloe vera and Bacopa monnieri have documented correlations and also need to be explored more. Molecules like garcinol (34), which was originally an anticancer compound, have good correlation as neuroprotective agent. Likewise many plants that have not been explored but are used in traditional system of medicine have also been listed. Jaggery and honey, which are used in traditional formulations in large quantity, also have natural products that are used as neuroprotective agents. In conclusion, a lot more study is required to correlate the medicinal plants and herbal formulations to have much more natural products for neurodegenerative disorders.

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Section: Berberine From Berberis Aristata DCmentioning

confidence: 96%

Bioactive Molecules from Indian Medicinal Plants as Possible Candidates for the Management of Neurodegenerative Disorders

Lal¹,

Lal²

2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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“…A good reduction in the β -amyloid plaque was noticed. Soudi et al synthesized surface-modified berberine chitosan nanoparticles modified with the tween 80, PEG4000, and miltefosine against lipopolysaccharide [ 158 ]. The synthesized formulation showed the neuroprotective behavior against lipopolysaccharide-activated cerebral and associated liver changes in rats.…”

Section: Nanocarrier Containing Natural Product Used To Combat Alzheimer's Diseasementioning

confidence: 99%

Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease

Singh

Nand

Maurya

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Since primitive times, herbs have been extensively used in conventional remedies for boosting cognitive impairment and age-associated memory loss. It is mentioned that medicinal plants have a variety of dynamic components, and they have become a prominent choice for synthetic medications for the care of cognitive and associated disorders. Herbal remedies have played a major role in the progression of medicine, and many advanced drugs have already been developed. Many studies have endorsed practicing herbal remedies with phytoconstituents, for healing Alzheimer’s disease (AD). All the information in this article was collated from selected research papers from online scientific databases, such as PubMed, Web of Science, and Scopus. The aim of this article is to convey the potential of herbal remedies for the prospect management of Alzheimer’s and related diseases. Herbal remedies may be useful in the discovery and advancement of drugs, thus extending new leads for neurodegenerative diseases such as AD. Nanocarriers play a significant role in delivering herbal medicaments to a specific target. Therefore, many drugs have been described for the management of age-linked complaints such as dementia, AD, and the like. Several phytochemicals are capable of managing AD, but their therapeutic claims are restricted due to their lower solubility and metabolism. These limitations of natural therapeutics can be overcome by using a targeted nanocarrier system. This article will provide the primitive remedies as well as the development of herbal remedies for AD management.

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“…BBR-NPs formulation (4 mg/kg, intraperitoneal, i.p.) was administered for 14 days, and on the 15 th -day lipopolysaccharide (LPS), BBR-NPs showed significant implication on the neuroprotective and hepatoprotective effects (Soudi et al, 2019). Another study demonstrated the pharmacokinetic parameters of BBR, following intragastric administration at a dose of 25 mg/kg in normal and diseased rats (post inflammatory irritable bowel syndrome).…”

Section: Preclinical Studiesmentioning

confidence: 99%