Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats

Bedir, Fevzi; Kocatürk, Hüseyin; Yapanoğlu, Turgut; Gürsul, Cebrail; Arslan, Remzi; Mammadov, Renad; Çoban, Abdülkadir; Altuner, Durdu; Süleyman, Halis

doi:10.1016/j.biopha.2021.111660

Cited by 29 publications

(22 citation statements)

References 32 publications

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“…In accordance with our results, several investigations have shown that the cardioprotective action of TAX is associated with reduced oxidative markers and elevated antioxidant components, resulting in ameliorated oxidative injury to the myocardium [ 39 , 40 , 49 ]. Furthermore, TAX exhibited tissue protective effect against chemically-induced oxidative damage in various experimental models, such as acrylamide-induced heart [ 21 ] and kidney injury [ 50 ], alcohol [ 25 ] and carbon tetrachloride (CCl 4 )-induced liver injury [ 25 ], and methanol-induced oxidative optic nerve damage [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice

et al. 2022

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Oxidative stress and inflammation are key components in cardiovascular diseases and heart dysfunction. Herein, we evaluated the protective effects of (+)-taxifolin (TAX), a potent flavonoid with significant antioxidant and anti-inflammatory actions, on myocardial oxidative tissue injury, inflammation, and cell death, using a mouse model of isoproterenol (ISO)-induced acute myocardial injury. Mice were given TAX (25 and 50 mg/kg, orally) for 14 days before receiving two subsequent injections of ISO (100 mg/kg, s.c.) at an interval of 24 h on the 15th and 16th days. The ISO-induced cardiac tissue injury was evidenced by increased serum creatine kinase-MB (CK-MB), cardiac troponin I (cTnI), and lactate dehydrogenase (LDH), along with several histopathological changes. The ISO also induced increased malondialdehyde (MDA) with concomitant declined myocardial glutathione level and antioxidant enzymes activities. Moreover, ISO-induced heart injury was accompained with elevated cardiac NF-κB p65, TNF-α, IL-1β, Bax, and caspase-3, as well as decreased Bcl-2, Nrf2, and HO-1. Remarkably, TAX reduced the severity of cardiac injury, oxidative stress, inflammation, and cell death, while enhancing antioxidants, Bcl-2, and Nrf2/HO-1 signaling in ISO-injected mice. In conclusion, TAX protects against ISO-induced acute myocardial injury via activating the Nrf2/HO-1 signaling pathway and attenuating the oxidative tissue injury and key regulators of inflammatory response and apoptosis. Thus, our findings imply that TAX may constitute a new cardioprotective therapy against acute MI, which undoubtedly deserves further exploration in upcoming human trials.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice

et al. 2022

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“…One hour after delivering taxifolin and distilled water, acrylamide was administered to the TACL and ACL groups at the dose of 20 mg/kg with a catheter, directly to the stomach. This procedure was repeated once a day for two months [13]. Bodyweight alterations, food and water intake were recorded daily.…”

Section: Methodsmentioning

confidence: 99%

“…Taxifolin is an antioxidant flavonoid that is abundantly found in onions, french maritime pine barks, milk thistles, and tamarind seeds [12]. Research reveals that taxifolin has antioxidant, anti-inflammatory, antiviral, antibacterial, anticancer, and neuroprotective effects [13][14][15][16]. In experimental studies, taxifolin was able to decrease oxidative tissue damage by inhibiting the overproduction of ROS [17,18].…”

Section: Introductionmentioning

confidence: 99%

The preventive effect of taxifolin on acrylamide-induced heart damage in rats

Coşgun

Coskun

Çelik³

2022

Rev. Nutr.

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Objective Acrylamide is a toxic compound widely used in industrial sectors. Acrylamide causes reactive oxygen species formation and the subsequent lipid peroxidation reaction, which plays an important role in the pathogenesis of oxidative damage. Taxifolin is a flavonoid with antioxidant properties that inhibit reactive oxygen species formation. In this study, we aimed to investigate the preventive effect of taxifolin on acrylamide-induced oxidative heart damage. Methods The rats were divided into three groups: Acrylamide, Acrylamide+Taxifolin , and Healthy group. Water and food intake and body weight alterations were recorded daily. Malondialdehyde, total glutathione, nuclear factor kappa-B, total oxidant status, and total antioxidant status levels were analyzed from the heart tissue. Troponin-I levels, the parameter known as a cardiac biomarker, were analyzed from the blood sample. The cardiac histopathologic examination was also performed. Results In the Acrylamide group animals, the malondialdehyde, nuclear factor kappa-B, total oxidant status, and troponin-I levels were significantly higher compared to the ones of Acrylamide+Taxifolin and Healthy groups. The levels of total glutathione and total antioxidant status were significantly lower compared to Acrylamide+Taxifolin and Healthy groups’. Additionally, in the Acrylamide group, body weight gain, food and water intake, significantly declined compared to the Acrylamide+Taxifolin and Healthy groups. However, in the Acrylamide+Taxifolin group, taxifolin supplementation brought these values close to Healthy group ones. Furthermore, taxifolin treatment ameliorated structural myocardial damage signs induced by acrylamide. Conclusion Acrylamide exposure significantly induced oxidative damage to rat heart tissue. Taxifolin was able to improve the toxic consequences of acrylamide biochemically and histopathologically, possibly due to its antioxidant properties.

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“…These procedures were repeated once daily for 30 days. At the end of that period, the animals were sacrificed under high-dose anesthesia (50 mg/kg thiopental sodium), and the brain tissues were removed and subjected to biochemical and histopathological examination 12 .…”

Section: Methodsmentioning

confidence: 99%

The effect of Hippophae rhamnoides L. extract on acrylamideinduced brain injury in rats

et al. 2021

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Purpose: Reactive oxygen species (ROS), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) have been shown in the pathogenesis of acrylamide neurotoxicity. Hippophae rhamnoides L. extract (HRE) has a cytoprotective effect by stabilizing the production of ROS, IL-1β and TNF-α. The objective of the article was to investigate the effect of HRE on acrylamide-induced brain damage in rats biochemically and histopathologically. Methods: To the HRE+acrylamide only (ACR) group (n=6) of the animals, HRE was administered orally at a dose of 50 mg / kg into the stomach by gavage. The same volume of solvent (olive oil) was administered orally to the ACR (n=6) and healthy (HG) (n=6) groups. One hour after HRE administration, acrylamide was given orally at a dose of 20 mg/kg to HRE+ACR and ACR groups in the same way. This procedure was repeated once a day for 30 days. At the end of this period, brain tissues extracted from animals killed with 50 mg/kg thiopental anesthesia were examined biochemically and histopathologically. Results: It has been shown that HRE prevents the increase of malondialdehyde (MDA), myeloperoxidase (MPO), IL-1β and TNF-α with acrylamide and the decrease of total glutathione (tGSH) and glutathione reductase (GSHRd) levels in brain tissue. Conclusions: HRE may be useful in the treatment of acrylamide-induced neurotoxicity.

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Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats

Cited by 29 publications

References 32 publications

Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice

Cardioprotective Effect of Taxifolin against Isoproterenol-Induced Cardiac Injury through Decreasing Oxidative Stress, Inflammation, and Cell Death, and Activating Nrf2/HO-1 in Mice

The preventive effect of taxifolin on acrylamide-induced heart damage in rats

The effect of Hippophae rhamnoides L. extract on acrylamideinduced brain injury in rats

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