Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats

Jadon, Arvind Singh; Bhadauria, Monika; Shukla, Sangeeta

doi:10.1016/j.jep.2006.07.033

Cited by 148 publications

(90 citation statements)

References 23 publications

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“…The results of our study showed that the antioxidant attributes may be accountable for the liver protective effects of GA. This finding is in compliance with earlier surveys, showing that GA protects the cells via reducing the generation of free radicals (39,47,50,51).…”

Section: Discussionsupporting

confidence: 93%

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The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

Goudarzi

Kalantar

2017

Jundishapur J Nat Pharm Prod

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Background: Mercury has a variety of industrial applications and is well-known for its hematotoxic, hepatotoxic, neurotoxic, nephrotoxic, and genotoxic effects. Objectives: This study was carried out to assess the protective effects of gallic acid against mercuric chloride-induced oxidative stress in albino rats. Methods: A total of 35 male Wistar rats were divided into 5 groups (7 rats per group). Groups 1 and 2 were used as the negative and positive controls, respectively and received normal saline (2 mL/kg/day, po) and mercuric chloride (0.4 mg/kg/day, po) for 28 days. Group 3 only received gallic acid (200 mg/kg/day, po) for 28 days, whereas groups 4 and 5 received gallic acid (50 and 200 mg/kg/day, respectively) after 1 hour, followed by mercuric chloride (0.4 mg/kg/day, po) for 28 days. Results:The results demonstrated that treatment with gallic acid significantly diminished the mercuric chloride-induced increase in the serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lipid peroxidation in liver tissues. In addition, gallic acid treatment increased the level of glutathione peroxidase, superoxide dismutase, and catalase activity and lowered the glutathione level in liver tissues, compared to the mercuric chloride group. The liver of rats, treated with mercuric chloride, showed degenerated cells (with mild cytoplasmic vacuolation and blebbing), binucleated cells, and significant sinusoidal dilation. Conclusions: It can be concluded that gallic acid restores the activities of antioxidant enzymes and tissue markers in mercuric chloride-treated rats, probably by scavenging free radicals and improving the antioxidant defense mechanisms.

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Section: Discussionsupporting

confidence: 93%

“…These results on GA may explain protection against pathological changes in the liver of rats, induced by HgCl 2 . In this regard, similar results have been reported by other researchers, indicating that GA diminishes the formation of MDA (39,47).…”

Section: Discussionsupporting

confidence: 92%

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

Goudarzi

Kalantar

2017

Jundishapur J Nat Pharm Prod

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“…Gallic acid has been reported to possess strong antioxidant, anti-inflammatory, antimutagenic and anticancer properties (Vijaya Padma et al 2011). Hepatoprotective effects coupled with the ability to inhibit lipid peroxidation have been demonstrated for gallic acid in carbon tetrachloride and lindane-induced liver injury (Jadon et al 2007;Vijaya Padma et al 2011). Similar effects have been demonstrated for catechin and catechin-rich extracts in carbon tetrachloride-induced liver injury , thioacetamide-induced liver fibrosis (Esmat et al 2013) and in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hepatocellular carcinoma in rodents (Monga et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Kujawska

Ewertowska

Adamska

et al. 2016

Pharmaceutical Biology

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Context Yellow tea containing the same catechins as other types of tea but in different proportions has been suggested to possess potent anticancer activities. Objective This study investigates the chemopreventive effect of yellow tea aqueous extract against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis in rats by employing histological and biochemical methods. Materials and methods Wistar rats were divided randomly into four groups: control (I), yellow tea (II), NDEA (III), and yellow tea + NDEA (IV). Groups II and IV were exposed via a diet to yellow tea extract in a concentration of 10 g/kg feed; groups III and IV received 0.01% NDEA in drinking water. The experiment lasted for 13 weeks. Results Daily intake of yellow tea in an average dose of 800 mg/kg b.w. alleviated the carcinogenic effect of NDEA as evidenced by reversed histopathological changes towards normal hepatocellular architecture and decreased lipid peroxidation, protein carbonyl formation, and DNA degradation by 64%, 37% and 15%, respectively, as compared with values obtained in NDEA alone-treated rats. Treatment with yellow tea extract caused protection of superoxide dismutase (SOD) and catalase (CAT); their activity was recovered by 47% and 12%, respectively, as compared with the NDEAtreated rats. Moreover, the extract normalized the NDEA-induced activity of paraoxonase 1 (PON1) and glutathione peroxidase (GPx), while a further increase in the level of reduced glutathione (GSH) was noticed. Conclusions On the basis of these findings, it can be concluded that treatment with yellow tea partially protected the livers of rats from NDEA-induced hepatocarcinogenesis and that its antioxidant activity contributed to this effect. ARTICLE HISTORY

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“…These processes affect the permeabilities of mitochondrial, endoplasmic reticulum, and plasma membranes, finally in leakage of liver enzymes into the blood. Therefore, estimation of enzymes in the serum is useful quantitative markers of the extent and types of hepatocellular damage (Jandon et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Liu

Geng

et al. 2014

Pharmaceutical Biology

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Objective: The present study investigates the hepatoprotective effect of Berchemia lineate ethanol extract (BELE) on CCl 4 -induced acute liver damage in mice. Materials and methods: Effect of BELE administrated for 7 consecutive days was evaluated in mice by the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), albulin (ALB), globulin (GLB), and total protein (TP) levels, as well as liver superoxide dismutase (SOD) activity and malondialdehyde (MDA) level. Moreover, histopathological examinations were also taken. SOD (291.17, 310.32, and 325.67 U/mg prot) and reduction of MDA (7.27, 6.77, and 5.33 nmol/mg prot) levels. Histopathological examinations also confirmed that BELE can ameliorate CCl 4 -induced liver injuries, characterized by extensive hepatocellular degeneration/necrosis, inflammatory cell infiltration, congestion, and sinusoidal dilatation. Discussion and conclusion: The results indicated that BELE possessed remarkable protective effect against acute hepatotoxicity and oxidative injuries induced by CCl 4 , and that the hepatoprotective effects of BELE may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.

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Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats

Cited by 148 publications

References 23 publications

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

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Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats

Cited by 148 publications

References 23 publications

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl4-induced acute hepatotoxicity in mice

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Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice